Prognostic significance of Dicer expression in ovarian cancer—link to global microRNA changes and oestrogen receptor expression

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Areeg Faggad ◽  
Jan Budczies ◽  
Oleg Tchernitsa ◽  
Silvia Darb-Esfahani ◽  
Jalid Sehouli ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Prognostic Significance ◽  
Receptor Expression ◽  
Dicer Expression

scholarly journals Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Robert Mechera ◽  
Savas D. Soysal ◽  
Salvatore Piscuoglio ◽  
Charlotte K. Y. Ng ◽  
Jasmin Zeindler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oestrogen Receptor ◽  
Prognostic Significance ◽  
Receptor Expression

Prolonged atrazine exposure beginning in utero and adult uterine morphology in mice

2021 ◽  
pp. 1-10
Author(s):  
Meaghan J. Griffiths ◽  
Amy L. Winship ◽  
Jessica M. Stringer ◽  
Elyse O. Swindells ◽  
Alesia P. Harper ◽  
...  
Keyword(s):  
Drinking Water ◽  
Oestrogen Receptor ◽  
Endometrial Hyperplasia ◽  
Epithelial To Mesenchymal Transition ◽  
Cell Metabolism ◽  
In Utero ◽  
Receptor Expression ◽  
Mesenchymal Transition ◽  
Pregnant Mice ◽  
Emt Markers

Abstract Through drinking water, humans are commonly exposed to atrazine, a herbicide that acts as an endocrine and metabolic disruptor. It interferes with steroidogenesis, including promoting oestrogen production and altering cell metabolism. However, its precise impact on uterine development remains unknown. This study aimed to determine the effect of prolonged atrazine exposure on the uterus. Pregnant mice (n = 5/group) received 5 mg/kg body weight/day atrazine or DMSO in drinking water from gestational day 9.5 until weaning. Offspring continued to be exposed until 3 or 6 months of age (n = 5–9/group), when uteri were collected for morphological and molecular analyses and steroid quantification. Endometrial hyperplasia and leiomyoma were evident in the uteri of atrazine-exposed mice. Uterine oestrogen concentration, oestrogen receptor expression, and localisation were similar between groups, at both ages (P > 0.1). The expression and localisation of key epithelial-to-mesenchymal transition (EMT) genes and proteins, critical for tumourigenesis, remained unchanged between treatments, at both ages (P > 0.1). Hence, oestrogen-mediated changes to established EMT markers do not appear to underlie abnormal uterine morphology evident in atrazine exposure mice. This is the first report of abnormal uterine morphology following prolonged atrazine exposure starting in utero, it is likely that the abnormalities identified would negatively affect female fertility, although mechanisms remain unknown and require further study.

Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network

2019 ◽  
Vol 85 ◽  
pp. 299-308 ◽  
Author(s):  
Jalid Sehouli ◽  
Elena Ioana Braicu ◽  
Rolf Richter ◽  
Carsten Denkert ◽  
Paul Jank ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Hormone Receptor ◽  
Prognostic Significance ◽  
Receptor Expression ◽  
Low Grade ◽  
Ki 67 ◽  
Serous Ovarian Carcinoma ◽  
Hormone Receptor Expression ◽  
Cancer Network

scholarly journals Prognostic Significance of Deregulated Dicer Expression in Breast Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83724 ◽  
Author(s):  
Emer Caffrey ◽  
Helen Ingoldsby ◽  
Deirdre Wall ◽  
Mark Webber ◽  
Kate Dinneen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Significance ◽  
Dicer Expression

scholarly journals Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women

2001 ◽  
Vol 3 (5) ◽  
Author(s):  
James S Lawson ◽  
Andrew S Field ◽  
Dinh D Tran ◽  
Nehmat Houssami
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Oestrogen Receptor ◽  
Hormone Replacement ◽  
Receptor Expression

scholarly journals The reliability of assessment of oestrogen receptor expression on needle core biopsy specimens of invasive carcinomas of the breast

2006 ◽  
Vol 60 (3) ◽  
pp. 299-302 ◽  
Author(s):  
Z. Hodi ◽  
J. Chakrabarti ◽  
A. H S Lee ◽  
J. E Ronan ◽  
C. W Elston ◽  
...  
Keyword(s):  
Core Biopsy ◽  
Oestrogen Receptor ◽  
Receptor Expression ◽  
Needle Core Biopsy ◽  
Biopsy Specimens ◽  
Invasive Carcinomas

Daidzein affects steroidogenesis and oestrogen receptor expression in medium ovarian follicles of pigs

2013 ◽  
Vol 61 (1) ◽  
pp. 85-98 ◽  
Author(s):  
Anna Nynca ◽  
Dominika Słonina ◽  
Olga Jablońska ◽  
Barbara Kamińska ◽  
Renata Ciereszko
Keyword(s):  
Protein Expression ◽  
Granulosa Cells ◽  
Oestrogen Receptor ◽  
Receptor Expression ◽  
Progesterone Production ◽  
Progesterone Secretion ◽  
Mrna And Protein Expression ◽  
Induced Changes ◽  
Reproductive Processes

Daidzein, a phytoestrogen present in soybean products used in swine feed, has been demonstrated to affect both reproductive and endocrine functions. The aims of this study were to examine the in vitro effects of daidzein on (1) progesterone (P4) and oestradiol (E2) secretion by porcine luteinised granulosa cells harvested from medium follicles, and (2) the mRNA and protein expression of oestrogen receptors α and β (ERα and ERβ) in these cells. The influence of E2 on P4 secretion and ERα and ERβ expression in the granulosa cells of pigs was also investigated. It was found that daidzein inhibited progesterone secretion by luteinised granulosa cells isolated from medium follicles. In contrast, E2 did not affect progesterone production by these cells. Moreover, daidzein did not alter the granulosal secretion of E2. Both daidzein and E2 decreased mRNA expression of ERα in the cells examined. The expression of ERβ mRNA was not affected by daidzein but was inhibited by E2. ERα protein was not detected while ERβ protein was found in the nuclei of the cells. Daidzein and E2 upregulated the expression of ERβ protein in the cells. In summary, the phytoestrogen daidzein directly affected the porcine ovary by inhibiting progesterone production and increasing ERβ protein expression. Daidzein-induced changes in follicular steroidogenesis and granulosal sensitivity to oestrogens may disturb reproductive processes in pigs.

scholarly journals Methylation of the NT5E Gene Is Associated with Poor Prognostic Factors in Breast Cancer

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 939
Author(s):  
Young Ju Jeong ◽  
Hoon Kyu Oh ◽  
Hye Ryeon Choi ◽  
Sung Hwan Park
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Methylation Status ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Receptor Expression ◽  
Gene Methylation ◽  
Clinicopathologic Characteristics ◽  
Large Tumor ◽  
The Mean

Cluster of differentiation (CD) 73, which is encoded by the NT5E gene, regulates production of immunosuppressive adenosine and is an emerging checkpoint in cancer immunotherapy. Despite the significance of CD73 in immuno-oncology, the roles of the NT5E gene methylation in breast cancer have not been well-defined yet. Therefore, we aimed to investigate the prognostic significance of the NT5E gene methylation in breast cancer. The DNA methylation status of the NT5E gene was analyzed using pyrosequencing in breast cancer tissues. In addition, the levels of inflammatory markers and lymphocyte infiltration were evaluated. The mean methylation level of the NT5E gene was significantly higher in breast cancer than in normal breast tissues. In the analysis of relevance with clinicopathologic characteristics, the mean methylation levels of the NT5E gene were significantly higher in patients with large tumor size, high histologic grade, negative estrogen receptor expression, negative Bcl-2 expression, and premenopausal women. There was no difference in disease-free survival according to the methylation status of the NT5E gene. We found that the NT5E gene methylation was related to breast cancer development and associated with poor prognostic factors in breast cancer. Our results suggest that the NT5E gene methylation has potential as an epigenetic biomarker in breast cancer.

scholarly journals A possible prognostic significance of c-Kit receptor expression and angiogenesis in early breast cancer patients: a pilot study

2015 ◽  
Vol 26 ◽  
pp. vi18
Author(s):  
M. Ammendola ◽  
I. Marech ◽  
C. Leporini ◽  
R. Patruno ◽  
M. Luposella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Prognostic Significance ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Kit Receptor
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