Role of active follow-up for early diagnosis of relapse after elective end of therapies

Introduction: Ultrasound and colorDoppler technique, which is relatively inexpensive, rapid, non-invasive and repeatable is a powerful tool used for early diagnosis of vascular access (VA) complications in hemodialysis patients. To date a standard and widely comprehensible echocolorDoppler (ECD) protocol is not available. Materials and Methods: A simple step-by-step protocol based on anatomical and hemodynamic parameters of VA has been developed during a 3-years VA ECD follow-up. It consists of an ECD study scheme. The algorithm created involves the calculation of brachial artery flow, description of artero-venous and/or graft-vascular anastomosis and efferent vessel and/or graft. Results: The algorithm allows to formulate a medical report that takes into account both anatomic and hemodynamic parameters of the VA. Reduction of complications and the prevention of chronic complications as well as the early detection of acute problems were achieved. Discussion and Conclusion: The creation of a step-by-step protocol may simplify the multidisciplinary management of VA, its monitoring and the early diagnosis of its complications.

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New Horizons in Early Dementia Diagnosis: Can Cerebellar Stimulation Untangle the Knot?

Journal of Clinical Medicine ◽

10.3390/jcm8091470 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1470

Author(s):

Antonino Naro ◽

Angela Marra ◽

Luana Billeri ◽

Simona Portaro ◽

Rosaria De Luca ◽

...

Keyword(s):

Early Diagnosis ◽

New Horizons ◽

Diagnosis And Prognosis ◽

Challenging Tasks ◽

Early Dementia ◽

Diagnosis Of Dementia ◽

Theta Burst ◽

Cerebellar Stimulation

Differentiating Mild Cognitive Impairment (MCI) from dementia and estimating the risk of MCI-to-dementia conversion (MDC) are challenging tasks. Thus, objective tools are mandatory to get early diagnosis and prognosis. About that, there is a growing interest on the role of cerebellum-cerebrum connectivity (CCC). The aim of this study was to differentiate patients with an early diagnosis of dementia and MCI depending on the effects of a transcranial magnetic stimulation protocol (intermittent theta-burst stimulation -iTBS) delivered on the cerebellum able to modify cortico-cortical connectivity. Indeed, the risk of MDC is related to the response to iTBS, being higher in non-responder individuals. All patients with MCI, but eight (labelled as MCI-), showed preserved iTBS aftereffect. Contrariwise, none of the patients with dementia showed iTBS aftereffects. None of the patients showed EEG aftereffects following a sham TBS protocol. Five among the MCI- patients converted to dementia at 6-month follow-up. Our data suggest that cerebellar stimulation by means of iTBS may support the differential diagnosis between MCI and dementia and potentially identify the individuals with MCI who may be at risk of MDC. These findings may help clinicians to adopt a better prevention/follow-up strategy in such patients.

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Scleroma of the lower respiratory tract: a bronchoscopic study

The Journal of Laryngology & Otology ◽

10.1017/s0022215100127161 ◽

1994 ◽

Vol 108 (6) ◽

pp. 484-485 ◽

Cited By ~ 16

Author(s):

N. K. Soni

Keyword(s):

Early Diagnosis ◽

Respiratory Tract ◽

Lower Respiratory Tract ◽

Symptomatic Treatment ◽

Subglottic Region ◽

Proliferative Stage

AbstractTwenty cases suffering from rhinoscleroma were studied. Bronchoscopy was performed for detection of secondary involvement of the subglottic region, trachea and bronchus. The study revealed that the larynx was involved in 40 per cent, the trachea in 20 per cent and the bronchus in 10 per cent of cases. The intranasal lesion, endotracheal and endobroncheal lesions all occur in the form of an atrophic stage, granulomatous (proliferative) stage and finally a fibrotic or scarring stage. The role of bronchoscopy in early diagnosis, initial symptomatic treatment and in follow-up is discussed in the light of the available literature.

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Tumor Markers in the Diagnosis, Monitoring and Therapy of Pancreatic Cancer: State of the Art

The International Journal of Biological Markers ◽

10.1177/172460089501000401 ◽

1995 ◽

Vol 10 (4) ◽

pp. 189-199 ◽

Cited By ~ 16

Author(s):

M. Plebani ◽

D. Basso ◽

M.P. Panozzo ◽

P. Fogar ◽

G. Del Favero ◽

...

Keyword(s):

Pancreatic Cancer ◽

Early Diagnosis ◽

Tumor Markers ◽

State Of The Art ◽

Critical Evaluation ◽

Clinical Role ◽

Circulating Levels

The present review focuses on the utility of serum tumor markers in screening, diagnosis, prognosis and monitoring of pancreatic cancer. Serum determination of all tumor markers studied offers no help in screening or early diagnosis of pancreatic cancer. For diagnosis, blood group-related antigens, in particular CA 19-9, are considered the best indicators of this neoplasm. However, as occurs with other glycoproteic tumor markers, the circulating levels of CA 19-9 are significantly influenced by jaundice, probably because its liver metabolism is reduced. Therefore, the finding of elevated CA 19-9 levels in jaundiced patients has to be evaluated with caution. Since pancreatic cancer recurrences are not susceptible to treatment, the clinical role of widespread use of tumor marker determination in follow-up programs is limited and calls for a critical evaluation.

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Association of plasma proteins with rate of cognitive decline and dementia: 20-year follow-up of the Whitehall II and ARIC cohort studies

10.1101/2020.11.18.20234070 ◽

2020 ◽

Author(s):

Joni V. Lindbohm ◽

Nina Mars ◽

Keenan A. Walker ◽

Archana Singh-Manoux ◽

Gill Livingston ◽

...

Keyword(s):

Risk Factors ◽

Early Diagnosis ◽

Cognitive Decline ◽

Plasma Proteins ◽

Replication Cohort ◽

Dementia Risk ◽

Decline Rate ◽

Related Proteins

AbstractThe role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using a follow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort (ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. After replication and adjustment for known dementia risk factors, fifteen proteins were associated with cognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-related proteins. Currently approved medications can target five of the proteins. The results support systemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets for drug development.

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Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽

10.1027/0227-5910/a000364 ◽

2016 ◽

Vol 37 (2) ◽

pp. 130-139 ◽

Cited By ~ 9

Author(s):

Danica W. Y. Liu ◽

A. Kate Fairweather-Schmidt ◽

Richard Burns ◽

Rachel M. Roberts ◽

Kaarin J. Anstey

Keyword(s):

Risk Factors ◽

Well Being ◽

Current Status ◽

Psychological Resilience ◽

Cross Sectional ◽

Life Project ◽

Resilience Factors ◽

First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

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Abusive head trauma (AHT) outcome at long-term follow-up and the role of elective neurosurgical approach: A report of 22 cases

PsycEXTRA Dataset ◽

10.1037/e578482014-165 ◽

2013 ◽

Author(s):

Francesca Menegazzo ◽

Melissa Rosa Rizzotto ◽

Martina Bua ◽

Luisa Pinello ◽

Elisabetta Tono ◽

...

Keyword(s):

Head Trauma ◽

Abusive Head Trauma ◽

Long Term Follow Up

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Postural Changes in Essential Hypertension under Treatment and their Effect on the Renogram

Nuklearmedizin ◽

10.1055/s-0038-1624732 ◽

1971 ◽

Vol 10 (01) ◽

pp. 39-46

Author(s):

C. Alexandrou ◽

E. Papadakis ◽

E. Gyftaki ◽

J. Darsinos

Keyword(s):

Renal Function ◽

Essential Hypertension ◽

Early Diagnosis ◽

Postural Hypotension ◽

Antihypertensive Treatment ◽

Normal Subjects ◽

Upright Position ◽

Postural Changes ◽

Significant Impairment

SummaryRadioisotope renograms were obtained in the upright and prone position in 9 normal subjects, in 5 patients with untreated essential hypertension and in 21 hypertensives under treatment, showing moderate postural hypotension.No significant renographic change were seen in the two positions in normal subjects and untreated hypertensives. Treated hypertensives with postural hypotension showed significant impairment of renal function in the upright position in 15 cases and no change in 6. Renal creatinine clearance was lower in the group that showed renographic changes. Renography in the upright position is suggested as a convenient test for early diagnosis and follow-up of the adverse effects of antihypertensive treatment.

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