scholarly journals Effect of Ginkgo Biloba Extract on Lipopolysaccharide-induced Anhedonic Depressive-like Behavior in Male Rats

2014 ◽  
Vol 29 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Kuei-Ying Yeh ◽  
Sing-Siang Shou ◽  
Yi-Xuan Lin ◽  
Chao-Cin Chen ◽  
Chen-Yen Chiang ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Male Rats

Ginkgo biloba extract facilitates recovery from penetrating brain injury in adult male rats

1989 ◽  
Vol 105 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Michael J. Attella ◽  
Stuart W. Hoffman ◽  
Michael J. Stasio ◽  
Donald G. Stein
Keyword(s):  
Brain Injury ◽  
Adult Male ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Male Rats ◽  
Penetrating Brain Injury

Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl 4 in male rats

2010 ◽  
Vol 30 (3) ◽  
pp. 209-216 ◽  
Author(s):  
RM Chávez-Morales ◽  
F. Jaramillo-Juárez ◽  
FA Posadas del Río ◽  
MA Reyes-Romero ◽  
ML Rodríguez-Vázquez ◽  
...  
Keyword(s):  
Steady State ◽  
Ginkgo Biloba ◽  
State Level ◽  
Ginkgo Biloba Extract ◽  
Male Rats ◽  
Albumin Concentration ◽  
Steady State Level ◽  
Morphological Alterations ◽  
Central Lobe ◽  
Nuclear Alterations

Functional and morphological alterations were generated by p.o. (per os) administration of a single oral dose of carbon tetrachloride (CCl4; 0.125 mL/kg b.w., equivalent to 293 mg/kg) to adult male Wistar rats. CCl4 significantly increased (p < 0.05) the serum activities of alanine aminotransferase (ALT; 7478 ± 1044%) and aspartate aminotransferase (AST; 6964 ± 833%), compared to control rats; CCl4 also significantly decreased serum concentration of albumin (23 ± 5.5%) and increased the concentration of malondialhdeyde (MDA) in liver (300 ± 33%). Furthermore, CCl 4 down-regulated the mRNA steady-state level of tumor necrosis factor a(TNF-a). CCl4 produced necrosis in the central lobe area, extended to the periphery, nuclear alterations (pycnosis, karyolysis and karyorrhexis), and cytoplasmic acidophilia. The pretreatment with 4 mg/kg (p.o.) of Ginkgo biloba extract (GbE), for 5 days, prevented most of the damage caused by CCl4: significantly decreased the serum activities of ALT and AST (54 and 65%, respectively), compared to CCl4-treated rats; GbE partially prevented the increase of liver MDA (55 ± 14%) and the decrease of albumin concentration to 12 ± 0.2%. This pretreatment prevented the down-regulation of TNF-a and up-regulated the interleukine 6 (IL-6) mRNA steady-state level. Moreover, the GbE reduced the amount of necrotic areas in the central lobe area, compared to CCl4-treated rats.

The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats

2017 ◽  
Vol 69 (7) ◽  
pp. 430-434 ◽  
Author(s):  
R.M. Chávez-Morales ◽  
F. Jaramillo-Juárez ◽  
M.L. Rodríguez-Vázquez ◽  
M.C. Martínez-Saldaña ◽  
F.A. Posadas del Río ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Adult Male ◽  
Ginkgo Biloba ◽  
Low Dose ◽  
Ginkgo Biloba Extract ◽  
Male Rats

scholarly journals A Single Dose of Ginkgo biloba Extract Induces Gene Expression of Hypothalamic Anorexigenic Effectors in Male Rats

2021 ◽  
Vol 11 (12) ◽  
pp. 1602
Author(s):  
Meira M. F. Machado ◽  
Janilda P. Pereira ◽  
Bruna K. S. Hirata ◽  
Viviane S. Júlio ◽  
Renata M. Banin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Food Intake ◽  
Body Mass ◽  
Ginkgo Biloba ◽  
Mass Gain ◽  
Ginkgo Biloba Extract ◽  
Male Rats ◽  
Ovariectomized Rats ◽  
Protein Levels ◽  
Rapid Stimulation

Previous studies have shown that Ginkgo biloba extract (GbE) reduces food intake and body mass gain and regulates proteins related to lipid metabolism in obese rats. In ovariectomized rats, GbE restored the hippocampal and hypothalamic serotonergic system activity, favoring the spontaneous feeding decrement. Considering the promising hypophagic effect of GbE, this study aimed to investigate the effect of a single acute dose on hypothalamic pathways that regulate feeding behavior in male rats. Four-month-old Wistar male rats received either a single acute oral GbE dose (500 mg/kg) or vehicle. Food intake and body mass were measured after 1, 4, 12, and 24 h. Rats were euthanized, and hypothalami were removed for mRNA quantification of anorexigenic (POMC/CART) and orexigenic (AgRP/NPY) neuropeptides, leptin/serotonin receptors (5HT1A, 5HT1B, 5HT2C), and serotonin transporters. We also investigated POMC, 5-HT1B, and 5-HT2C protein levels. A single acute GbE dose induced the hypothalamic POMC, CART, and 5-HT2C gene expression but failed to modify orexigenic effectors. No alterations in food intake, body mass, and hypothalamic protein levels were observed. In summary, the present findings demonstrate the rapid stimulation of pivotal hypothalamic anorexigenic pathways in response to a single GbE administration, reinforcing the GbE hypophagic activity. However, more studies are necessary to evaluate its potential as an appetite modulator.

Quality Control Optimization Solutions for Determination of Rutin in Supplements Containing Ginkgo Biloba Extract

2016 ◽  
Vol 12 (4) ◽  
pp. 386-390 ◽  
Author(s):  
Ivanka P. Pencheva ◽  
Vania N. Maslarska ◽  
Assena C. Stoimenova ◽  
Manoela M. Manova ◽  
Lily A. Andonova ◽  
...  
Keyword(s):  
Quality Control ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Control Optimization

Quantitative GC-FID and UHPLC-DAD Evaluation of Bioactive Compounds Extracted from Ginkgo biloba

2020 ◽  
Vol 16 (7) ◽  
pp. 893-904
Author(s):  
Alessandra von Ahn ◽  
João Henrique Z. dos Santos
Keyword(s):  
Ginkgo Biloba ◽  
Extraction Efficiency ◽  
Extraction Methods ◽  
Ginkgo Biloba Extract ◽  
Previous Method ◽  
Array Detector ◽  
Ginkgolide B ◽  
Detection Techniques ◽  
Ginkgolide A ◽  
Terpene Trilactones

Background: The official compendium of the quantification of ginkgo flavonoids from Ginkgo biloba extract has been proposed using HPLC. The drawbacks of this technique appear to be due to the restricted efficiency in terms of the recovery results and suitability of the system for the quantification of these compounds. This study investigated the potential advantages and limitations of the development of efficient extraction methods for the recovery of flavonol glycosides (quercetin, kaempferol and isorhamnetin) and terpene trilactones (bilobalide, ginkgolide A, ginkgolide B and ginkgolide C) using extraction, quantification and detection techniques, namely, GC-FID and UHPLC-DAD, which are alternatives to those techniques available in the literature. Methods: Two different extraction methodologies have been developed for the determination of flavonoids (quercetin, kaempferol and isorhamnetin) and terpene trilactones (bilobalide, ginkgolide A, ginkgolide B and ginkgolide C) using ultra-high-pressure liquid chromatography coupled to a diode array detector and gas chromatography coupled to a flame ionization detector. Results: In this study, the Ginkgo biloba extract mass, hydrolysis preparation method (with or without reflux), and volume of the extraction solution seemed to affect the ginkgo flavonoid recovery. The UHPLC-based method exhibited higher extraction efficiency for ginkgo flavonoid quantification compared to the pharmacopoeial method. The developed method exhibited higher extraction efficiency for terpene quantification compared to the previous method that used extractive solution without pH adjustment, with less time of extraction and less amount of the sample and organic solvent aliquots. Conclusion: The UHPLC and GC analysis methods established in this study are both effective and efficient. These methods may improve the quality control procedures for ginkgo extract and commercial products available in today´s natural health product market. The results indicate that redeveloped extraction methods can be a viable alternative to traditional extraction methods.

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