Stevia is a small perennial shrub belonging to the Astraceae family with approximately 240 species,
which has been used as a natural sweetener. In addition to its sweetening property, it has medicinal
values and other uses. Indigenous tribes of South America were using Stevia rebaudiana Bertoni for
centuries for its medicinal value. Leaves of stevia produce diterpene glycosides (Stevioside and
Rebaudiosides), non-nutritive, non-toxic, high-potency sweeteners. The traditional medicinal system
is getting more and more appreciation nowadays, but the therapeutic targets for most of these medicines
remain unclear, which slows down the novel drug discovery from these natural products. Computational
molecular docking studies are effective tools, which are broadly utilized to identify therapeutic targets
and interpret molecular aspects of the ligand-protein interactions during drug discovery. Thus, it also
enables the extraordinary structural diversity of natural products to be harnessed in an effective manner.
The aim of this article is to present a review on the molecular docking studies and pharmacological
activities of steviol glycoside isolated from Stevia rebaudiana. In this article, the recently published
papers about Stevia rebaudiana were reviewed, using scientific sites such as Mendeley, PubMed and
Google Scholar.
Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process
