Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells

2008 ◽  
pp. 103-129 ◽  
Author(s):  
John G. Pastorino ◽  
Jan B. Hoek
Keyword(s):  
Energy Metabolism ◽  
Tumor Cells ◽  
And Control

Cell Cycle and Energy Metabolism in Tumor Cells: Strategies for Drug Therapy

2011 ◽  
Vol 6 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Nivea D. Amoedo ◽  
Tatiana El-Bacha ◽  
Mariana F. Rodrigues ◽  
Franklin D. Rumjanek
Keyword(s):  
Cell Cycle ◽  
Drug Therapy ◽  
Energy Metabolism ◽  
Tumor Cells

scholarly journals Oxygen-Dependent Regulation of Energy Metabolism in Ascites Tumor Cells by Nitric Oxide

1997 ◽  
Vol 75 ◽  
pp. 100
Author(s):  
Manabu Nishikawa ◽  
Eisuke F. Sato ◽  
Tetsuo Kuroki ◽  
Kozo Utsumi ◽  
Masayasu Inoue
Keyword(s):  
Nitric Oxide ◽  
Energy Metabolism ◽  
Tumor Cells ◽  
Ascites Tumor

scholarly journals Bladder Tumor Heterogeneity: The Impact on Clinical Treatment

2015 ◽  
Vol 95 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Chao Chen ◽  
Xiang Jie Qi ◽  
Yan Wei Cao ◽  
Yong Hua Wang ◽  
Xue Cheng Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Treatment Failure ◽  
Tumor Cells ◽  
Cancer Progression ◽  
Tumor Heterogeneity ◽  
Bladder Tumor ◽  
Gene Sequencing ◽  
Generation Model ◽  
And Control ◽  
The Impact

Bladder cancer relapse and treatment failure in most patients have often been attributed to chemoresistance in tumor cells and metastasis. Emerging evidence indicates that tumor heterogeneity may play an equally important role and extends to virtually all measurable properties of cancer cells. Although the idea of tumor heterogeneity is not new, little attention has been paid to applying it to understand and control bladder cancer progression. With the development of biotechnology, such as Gene sequencing, recent advances in understanding its generation model, original basis, consequent problems, and derived therapies provide great potential for tumor heterogeneity to be considered a new insight in the treatment of bladder cancers.

scholarly journals Mitochondrial energy metabolism in a model of undernutrition induced by dexamethasone

2003 ◽  
Vol 90 (5) ◽  
pp. 969-977 ◽  
Author(s):  
Jean-François Dumas ◽  
Gilles Simard ◽  
Damien Roussel ◽  
Olivier Douay ◽  
Françoise Foussard ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Treated Group ◽  
Liver Mitochondria ◽  
Proton Leak ◽  
Thermodynamic Efficiency ◽  
Liver Mass ◽  
Mitochondrial Energy Metabolism ◽  
Thermodynamic Coupling ◽  
And Control ◽  
Complex Activities

The present investigation was undertaken to evaluate whether mitochondrial energy metabolism is altered in a model of malnutrition induced by dexamethasone (DEX) treatment (1·5mg/kg per d for 5d). The gastrocnemius and liver mitochondria were isolated from DEX-treated, pair-fed (PF) and control (CON) rats. Body weight was reduced significantly more in the DEX-treated group (−16%) than in the PF group (−9%). DEX treatment increased liver mass (+59% v. PF, +23% v. CON) and decreased gastrocnemius mass. Moreover, in DEX-treated rats, liver mitochondria had an increased rate of non-phosphorylative O2 consumption with all substrates (approximately +42%). There was no difference in enzymatic complex activities in liver mitochondria between rat groups. Collectively, these results suggest an increased proton leak and/or redox slipping in the liver mitochondria of DEX-treated rats. In addition, DEX decreased the thermodynamic coupling and efficiency of oxidative phosphorylation. We therefore suggest that this increase in the proton leak and/or redox slip in the liver is responsible for the decrease in the thermodynamic efficiency of energy conversion. In contrast, none of the variables of energy metabolism determined in gastrocnemius mitochondria was altered by DEX treatment. Therefore, it appears that DEX specifically affects mitochondrial energy metabolism in the liver.

scholarly journals Endocrine And Metabolic Adaptations Of Calves To Extra-Uterine Life

2015 ◽  
Vol 65 (3) ◽  
pp. 297-318 ◽  
Author(s):  
Kirovski Danijela
Keyword(s):  
Energy Metabolism ◽  
Thyroid Hormones ◽  
Energy Intake ◽  
Environmental Temperature ◽  
Endocrine System ◽  
Energy Sources ◽  
Functional Changes ◽  
Metabolic Adaptations ◽  
Newborn Calves ◽  
And Control

AbstractThe transition from intra- to extra-uterine life is one of the greatest physiological challenges that occur in the life of animals. Immediately after birth, newborn calves have to adapt to new environmental and feeding conditions. Namely, at birth a break of the thermal balance occurs, since calves abruptly pass from a 38.8°C temperaturein uteroto an environmental temperature that is generally lower than 20°C. Additionally, at birth, the energy intake shifts from a continuous parenteral supply of nutrients (mainly glucose) to discontinuous colostrum and milk intake with lactose and fat as the main energy sources. Therefore, the most important issues related to metabolic changes during the transition from intra- to extra-uterine life are related to maintaining the homoeothermic conditions and control of energy metabolism. Those metabolic adaptations are under control of the endocrine system that is relatively mature at birth, but still requires morphological and functional changes after birth. Key hormones whose concentrations are significantly changed around birth and are involved in an adequate adaptation of calves to extra-uterine life are those related to stress at birth (cortisol and cathecholamines), glucoregulatory processes (insulin and glucagon), thermogenesis (thyroid hormones) and growth (IGF axis).

scholarly journals The control systems structures of energy metabolism

2009 ◽  
Vol 7 (45) ◽  
pp. 651-665 ◽  
Author(s):  
Mathieu Cloutier ◽  
Peter Wellstead
Keyword(s):  
Energy Metabolism ◽  
Control Systems ◽  
Enzymatic Reaction ◽  
Reaction Rates ◽  
Control Mechanisms ◽  
Energy Regulation ◽  
Systematic Analysis ◽  
Perfect Adaptation ◽  
Energetic State ◽  
And Control

The biochemical regulation of energy metabolism (EM) allows cells to modulate their energetic output depending on available substrates and requirements. To this end, numerous biomolecular mechanisms exist that allow the sensing of the energetic state and corresponding adjustment of enzymatic reaction rates. This regulation is known to induce dynamic systems properties such as oscillations or perfect adaptation. Although the various mechanisms of energy regulation have been studied in detail from many angles at the experimental and theoretical levels, no framework is available for the systematic analysis of EM from a control systems perspective. In this study, we have used principles well known in control to clarify the basic system features that govern EM. The major result is a subdivision of the biomolecular mechanisms of energy regulation in terms of widely used engineering control mechanisms: proportional, integral, derivative control, and structures: feedback, cascade and feed-forward control. Evidence for each mechanism and structure is demonstrated and the implications for systems properties are shown through simulations. As the equivalence between biological systems and control components presented here is generic, it is also hypothesized that our work could eventually have an applicability that is much wider than the focus of the current study.

Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane

Mitochondrion ◽  
2007 ◽  
Vol 7 (3) ◽  
pp. 234-240 ◽  
Author(s):  
Valsala Haridas ◽  
Xiaoxian Li ◽  
Takatsugu Mizumachi ◽  
Masahiro Higuchi ◽  
Viktor V. Lemeshko ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Tumor Cells ◽  
Mitochondrial Membrane ◽  
Outer Mitochondrial Membrane

scholarly journals Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinsons disease

2021 ◽  
Author(s):  
Pedro Alexandre Pereira ◽  
Drupad Trivedi ◽  
Justin Silverman ◽  
Ilhan Duru ◽  
Lars K Paulin ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Bacterial Community ◽  
Bacterial Community Composition ◽  
Control Groups ◽  
Parkinsons Disease ◽  
Clinical Variables ◽  
Metabolite Profiles ◽  
Healthy Control ◽  
And Control ◽  
Altered Lipid

We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinsons disease (PD) and healthy control subjects (HC). 139 metabolite features were found to be differentially abundant between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.

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