High-Intensity, Low-Frequency Catheter-Delivered Ultrasound for Thrombus Dissolution

Author(s):  
Robert J. Siegel ◽  
Wolfgang Steffen ◽  
Huai Luo ◽  
Jean Marzelle ◽  
Michael C. Fishbein
Keyword(s):  
2021 ◽  
Vol 71 ◽  
pp. 105363
Author(s):  
Olga Krasulya ◽  
Anastasiya Smirnova ◽  
Vladimir Bogush ◽  
Natalia Shlenskaya ◽  
Natalia Vostrikova ◽  
...  

1994 ◽  
Vol 71 (1) ◽  
pp. 216-228 ◽  
Author(s):  
S. Jeftinija ◽  
L. Urban

1. The effects of repetitive stimulation of primary afferents in lumbar dorsal roots on synaptic transmission in the dorsal horn (DH) were studied in a rat spinal cord slice-dorsal root ganglion (DRG)-peripheral nerve trunk preparation by the use of intracellular recording from neurons (n = 115) of the spinal dorsal horn (depth 147 +/- 139, mean +/- SD). All DH neurons were excited synaptically by electrical stimulation of the dorsal root or the peripheral nerve trunk. The electrical shocks were calibrated to produce activation either of large fibers (10–20 V, 0.02 ms) or the whole fiber population including unmyelinated afferents (supramaximal stimulus: > 35 V, 0.5 ms). Postsynaptic potentials induced by low intensity repetitive stimulation of primary afferents at frequencies below 5 Hz failed to produce a prolonged change in the resting membrane potential. In 97/115 DH neurons, slow excitatory postsynaptic potentials (EPSP)--evoked by high intensity low-frequency repetitive stimulation (0.1–2 Hz) of primary afferents--summated, producing a prolonged cumulative depolarization. In the remaining 18/115 DH neurons, high intensity low-frequency stimulation produced a cumulative hyperpolarizing response. 2. In 22 of 97 neurons that responded to high intensity repetitive stimulation with a cumulative depolarization, wind-up in the firing of action potentials was recorded. In all but two experiments, neurons that responded with wind-up to stimulation of one root responded with wind-up to stimulation of the adjacent dorsal root. In 14/22 wind-up neurons, the synaptic response to high intensity stimulation of primary afferents was composed of a short latency EPSP, followed by an inhibitory postsynaptic potential (IPSP), followed by a slow EPSP. The decrease of the amplitude and duration of the IPSP obtained during train stimulation did not seem to contribute to facilitation of transmission induced by repetitive stimulation. 3. The wind-up in firing of action potentials was followed by a prolonged potentiation of synaptic transmission in tetanized synapses. A test of other, adjacent primary afferents revealed that these synapses in the neurons in the superficial laminae had not undergone potentiation. This “synaptic specificity” of post-wind-up potentiation suggested that the mechanism for the induction of stimulation-dependent changes in the excitability of the DH neuron is presynaptic to the recorded-from neuron. 4. In a concentration of 0.5 microM and higher, tetrodotoxin (TTX) applied to sensory neurons selectively blocked action potentials in large myelinated primary afferents.(ABSTRACT TRUNCATED AT 400 WORDS)


Author(s):  
Q. S. Feng ◽  
L. H. Cao ◽  
Z. J. Liu ◽  
C. Y. Zheng ◽  
X. T. He

The strong-coupling mode, called the “quasimode”, is excited by stimulated Brillouin scattering (SBS) in high-intensity laser–plasma interactions. Also SBS of the quasimode competes with SBS of the fast mode (or slow mode) in multi-ion species plasmas, thus leading to a low-frequency burst behavior of SBS reflectivity. Competition between the quasimode and the ion-acoustic wave (IAW) is an important saturation mechanism of SBS in high-intensity laser–plasma interactions. These results give a clear explanation of the low-frequency periodic burst behavior of SBS and should be considered as a saturation mechanism of SBS in high-intensity laser–plasma interactions.


2020 ◽  
Vol 123 (5) ◽  
pp. 1969-1978
Author(s):  
Jessica M. D’Amico ◽  
Siobhan C. Dongés ◽  
Janet L. Taylor

In this study, we present a novel, intensity-dependent repetitive transcranial magnetic stimulation (rTMS) protocol that induces lasting, plastic changes within the corticospinal tract. High-intensity rTMS at a frequency of 0.1 Hz induces facilitation of motor evoked potentials (MEPs) lasting at least 35 min. Additionally, these changes are not limited only to small MEPs but occur throughout the recruitment curve. Finally, facilitation of MEPs following high-intensity rTMS does not appear to be due to changes in intracortical inhibition or facilitation.


2011 ◽  
Vol 24 (2) ◽  
pp. 411-422 ◽  
Author(s):  
P. Palumbo ◽  
B. Cinque ◽  
G. Miconi ◽  
C. La Torre ◽  
G. Zoccali ◽  
...  

1994 ◽  
Vol 24 (6) ◽  
pp. 1571-1579 ◽  
Author(s):  
Wolfgang Steffen ◽  
Michael C. Fishbein ◽  
Huai Luo ◽  
Du-Yi Lee ◽  
Henry Nitams ◽  
...  

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