Molecular Hydrogen Consumption in the Human Body During the Inhalation of Hydrogen Gas

2013 ◽  
pp. 315-321 ◽  
Author(s):  
Akito Shimouchi ◽  
Kazutoshi Nose ◽  
Tomoe Mizukami ◽  
Dock-Chil Che ◽  
Mikiyasu Shirai
Keyword(s):  
Human Body ◽  
Molecular Hydrogen ◽  
Hydrogen Gas ◽  
Hydrogen Consumption

scholarly journals Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Chi Liu ◽  
Ryosuke Kurokawa ◽  
Masayuki Fujino ◽  
Shinichi Hirano ◽  
Bunpei Sato ◽  
...  
Keyword(s):  
Hydrogen Concentration ◽  
Intravenous Administration ◽  
Molecular Hydrogen ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intraperitoneal Administration ◽  
Hydrogen Gas ◽  
Rat Blood ◽  
Beneficial Effects ◽  
Rat Tissue

Abstract Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical and therapeutic applications in the clinical setting. In the present study, the hydrogen concentration in rat blood and tissue was estimated. Wistar rats were orally administered hydrogen super-rich water (HSRW), intraperitoneal and intravenous administration of hydrogen super-rich saline (HSRS) and inhalation of hydrogen gas. A new method for determining the hydrogen concentration was then applied using high-quality sensor gas chromatography, after which the specimen was prepared via tissue homogenization in airtight tubes. This method allowed for the sensitive and stable determination of the hydrogen concentration. The hydrogen concentration reached a peak at 5 minutes after oral and intraperitoneal administration, compared to 1 minute after intravenous administration. Following inhalation of hydrogen gas, the hydrogen concentration was found to be significantly increased at 30 minutes and maintained the same level thereafter. These results demonstrate that accurately determining the hydrogen concentration in rat blood and organ tissue is very useful and important for the application of various novel medical and therapeutic therapies using molecular hydrogen.

scholarly journals Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss

2021 ◽  
Vol 15 ◽  
Author(s):  
Anette Elisabeth Fransson ◽  
Pernilla Videhult Pierre ◽  
Mårten Risling ◽  
Göran Frans Emanuel Laurell
Keyword(s):  
Hearing Loss ◽  
Molecular Hydrogen ◽  
Noise Exposure ◽  
Real Life ◽  
Outer Hair Cells ◽  
Broadband Noise ◽  
Hydrogen Gas ◽  
Rescue Treatment ◽  
Brainstem Response ◽  
Antioxidant Effects

Noise exposure is the most important external factor causing acquired hearing loss in humans, and it is strongly associated with the production of reactive oxygen species (ROS) in the cochlea. Several studies reported that the administration of various compounds with antioxidant effects can treat oxidative stress-induced hearing loss. However, traditional systemic drug administration to the human inner ear is problematic and has not been successful in a clinical setting. Thus, there is an urgent need to develop rescue treatment for patients with acute acoustic injuries. Hydrogen gas has antioxidant effects, rapid distribution, and distributes systemically after inhalation.The purpose of this study was to determine the protective efficacy of a single dose of molecular hydrogen (H2) on cochlear structures. Guinea pigs were divided into six groups and sacrificed immediately after or at 1 or 2 weeks. The animals were exposed to broadband noise for 2 h directly followed by 1-h inhalation of 2% H2 or room air. Electrophysiological hearing thresholds using frequency-specific auditory brainstem response (ABR) were measured prior to noise exposure and before sacrifice. ABR thresholds were significantly lower in H2-treated animals at 2 weeks after exposure, with significant preservation of outer hair cells in the entire cochlea. Quantification of synaptophysin immunoreactivity revealed that H2 inhalation protected the cochlear inner hair cell synaptic structures containing synaptophysin. The inflammatory response was greater in the stria vascularis, showing increased Iba1 due to H2 inhalation.Repeated administration of H2 inhalation may further improve the therapeutic effect. This animal model does not reproduce conditions in humans, highlighting the need for additional real-life studies in humans.

The Proper Motions of the Warm Molecular Hydrogen Gas in Herbig-Haro 1

1997 ◽  
Vol 486 (1) ◽  
pp. L55-L58 ◽  
Author(s):  
Alberto Noriega-Crespo ◽  
Peter M. Garnavich ◽  
Salvador Curiel ◽  
Alejandro C. Raga ◽  
Sandra Ayala
Keyword(s):  
Molecular Hydrogen ◽  
Hydrogen Gas ◽  
Proper Motions

scholarly journals Radiation-induced molecular hydrogen gas generation in the presence of aluminum alloy 1100

2020 ◽  
Vol 177 ◽  
pp. 109117
Author(s):  
Elizabeth H. Parker-Quaife ◽  
Christopher Verst ◽  
Colt R. Heathman ◽  
Peter R. Zalupski ◽  
Gregory P. Horne
Keyword(s):  
Aluminum Alloy ◽  
Molecular Hydrogen ◽  
Hydrogen Gas ◽  
Gas Generation ◽  
Radiation Induced

scholarly journals Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Keliang Xie ◽  
Lingling Liu ◽  
Yonghao Yu ◽  
Guolin Wang
Keyword(s):  
Inflammatory Response ◽  
Molecular Hydrogen ◽  
Therapeutic Strategy ◽  
Cecal Ligation ◽  
Organ Damage ◽  
Hydrogen Gas ◽  
Diagnostic Tools ◽  
Hydrogen Treatment ◽  
Cecal Ligation And Puncture ◽  
Monitoring Devices

Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF-κB and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.

Neuroprotective and preventative effects of molecular hydrogen

2020 ◽  
Vol 26 ◽  
Author(s):  
Mami Noda ◽  
Jiankang Liu ◽  
Jiangang Long
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Molecular Hydrogen ◽  
Neuronal Damage ◽  
Disease Model ◽  
Endocrine System ◽  
Hydrogen Gas ◽  
Tyrosine Kinase Receptor

: One of the beneficial effects of molecular hydrogen (H2 , hydrogen gas) is neuroprotection and prevention of neurological disorders. It is important and useful if taking H2 every day can prevent or ameliorate the progression of neurodegenerative disorders such as Parkinson’s disease or Alzheimer’s disease, both lacking specific therapeutic drugs. There are several mechanisms how H2 protects neuronal damage. Anti-oxidative, anti-inflammatory, and the regulation of endocrine system via stomach-brain connection seem to play an important role. In cellular and tissue level, H2 appears to prevent the production of reactive oxygen species (ROS), not only hydroxy radical（•OH）but also superoxide. In Parkinson’s disease model mice, chronic intake of H2 causes the release of ghrelin from the stomach. In Alzheimer’s disease model mice, sex-different neuroprotection is observed by chronic intake of H2 . In female mice, declines of estrogen and estrogen receptor- (ER) are prevented by H2 , upregulating brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB). The question how drinking H2 upregulates the release of ghrelin or attenuates the decline of estrogen remains to be investigated. The mechanism how H2 modulates endocrine systems and the fundamental question what or where is the target of H2 needs to be elucidated for better understanding of the effects of H2 .

RADIATION-INDUCED EXCHANGE OF DEUTERIUM BETWEEN HEAVY WATER AND DISSOLVED HYDROGEN

1957 ◽  
Vol 35 (1) ◽  
pp. 84-90 ◽  
Author(s):  
J. Bardwell ◽  
P. J. Dyne
Keyword(s):  
Heavy Water ◽  
Gamma Rays ◽  
Molecular Hydrogen ◽  
Room Temperature ◽  
Reaction Rate ◽  
Deuterium Oxide ◽  
Hydrogen Gas ◽  
Radiation Induced ◽  
Dissolved Hydrogen ◽  
Moderate Range

Exchange of deuterium between deuterium oxide and molecular hydrogen is induced by gamma rays from Co60. The reaction was studied by irradiating heavy water solutions saturated with hydrogen gas, and then analyzing the gas with a mass spectrometer. The reaction rate conforms to the exponential exchange law. The exchange yield is independent of dose rate and of hydrogen concentration over a moderate range. Prolonged irradiation leads to a steady state where the isotopic composition of the gas is close to that of the solution. This state differs greatly from that for thermodynamic equilibrium at room temperature.

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