Antioxidant and Cytoprotective Activity of Indole Derivatives Related to Melatonin

2003 ◽  
pp. 567-575 ◽  
Author(s):  
Marco Mor ◽  
Gilberto Spadoni ◽  
Giuseppe Diamantini ◽  
Annalida Bedini ◽  
Giorgio Tarzia ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
Cytoprotective Activity

scholarly journals Synthesis, antioxidant and cytoprotective activity evaluation of C-3 substituted indole derivatives

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Beata Jasiewicz ◽  
Weronika Kozanecka-Okupnik ◽  
Michał Przygodzki ◽  
Beata Warżajtis ◽  
Urszula Rychlewska ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Haemolytic Activity ◽  
Antioxidant Compounds ◽  
Radical Scavenger ◽  
Dependent Manner ◽  
Indole Derivatives ◽  
Shape Transformation ◽  
Electron Transfer Mechanism ◽  
Cytoprotective Activity ◽  
Rbc Membrane

AbstractA series of fifteen indole derivatives substituted at the C-3 position were synthesized and characterized. The antioxidant activity of all derivatives was investigated by three in vitro antioxidant assays, and the derivative with pyrrolidinedithiocarbamate moiety was the most active as a radical scavenger and Fe3+-Fe2+ reducer. It can be stated that possible hydrogen and electron transfer mechanism is suggested for the quenching of the free radical. Moreover, the indolyl radical stabilization and the presence of unsubstituted indole nitrogen atom are mandatory for the observed antioxidant activity, which strongly depends on the type of the substituent directly connected to the methylene group at the C-3 position. Human red blood cells (RBC) have been used as a cell model to study derivatives interaction with the cell membrane. Haemolytic activity and RBC shape transformation were observed for certain derivatives in a concentration-dependent manner. However, most of the derivatives at sublytic concentration showed high cytoprotective activity against oxidative haemolysis induced by 2,2′-azobis(2-methylpropionamidine) dihydrochloride (AAPH). The cytoprotective properties of derivatives can be explained mostly due to their interactions with the RBC membrane components. Taking together, theoretical estimations and experimental data confirm the beneficial interactions between the selected C-3 substituted indole derivatives and the RBC membrane under oxidative stress conditions. These results encourage us to further structural optimization of C-3 substituted indole derivatives as potent antioxidant compounds.

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications

2020 ◽  
Vol 24 (22) ◽  
pp. 2665-2693
Author(s):  
Dipayan Mondal ◽  
Pankaj Lal Kalar ◽  
Shivam Kori ◽  
Shovanlal Gayen ◽  
Kalpataru Das
Keyword(s):  
Biological Activities ◽  
Synthetic Methods ◽  
Pharmaceutical Chemistry ◽  
Indole Derivatives ◽  
Biological Studies ◽  
Recent Developments ◽  
Pharmaceutical Industries ◽  
Green Methodology ◽  
Conventional Methods ◽  
High Yields

Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities. Due to enormous applications of indole derivatives in pharmaceutical chemistry, a number of conventional synthetic methods as well as green methodology have been developed for their synthesis. Green methodology has many advantages including high yields, short reaction time, and inexpensive reagents, highly efficient and environmentally benign over conventional methods. Currently, the researchers in academia as well as in pharmaceutical industries have been developing various methods for the chemical synthesis of indole based compounds via green approaches to overcome the drawbacks of conventional methods. This review reflects the last ten years developments of the various greener methods for the synthesis of indole derivatives by using microwave, ionic liquids, water, ultrasound, nanocatalyst, green catalyst, multicomponent reaction and solvent-free reactions etc. (please see the scheme below). Furthermore, the applications of green chemistry towards developments of indole containing pharmaceuticals and their biological studies have been represented in this review.

C-3 Functionalization of Indole Derivatives with Isoquinolines

2016 ◽  
Vol 20 (20) ◽  
pp. 2038-2054 ◽  
Author(s):  
István Szatmári ◽  
Judit Sas ◽  
Ferenc Fülöp
Keyword(s):  
Indole Derivatives

Defensive Role of Plant-Derived Secondary Metabolites: Indole and Its’ Derivatives

2020 ◽  
Vol 9 (2) ◽  
pp. 78-88
Author(s):  
Mulugeta Mulat ◽  
Raksha Anand ◽  
Fazlurrahman Khan
Keyword(s):  
Biofilm Formation ◽  
Growth And Development ◽  
Functional Role ◽  
Plant Pathogens ◽  
Bacterial Species ◽  
Indole Derivatives ◽  
Resistance Level ◽  
Defensive Role ◽  
Insect Attack

The diversity of indole concerning its production and functional role has increased in both prokaryotic and eukaryotic systems. The bacterial species produce indole and use it as a signaling molecule at interspecies, intraspecies, and even at an interkingdom level for controlling the capability of drug resistance, level of virulence, and biofilm formation. Numerous indole derivatives have been found to play an important role in the different systems and are reported to occur in various bacteria, plants, human, and plant pathogens. Indole and its derivatives have been recognized for a defensive role against pests and insects in the plant kingdom. These indole derivatives are produced as a result of the breakdown of glucosinolate products at the time of insect attack or physical damages. Apart from the defensive role of these products, in plants, they also exhibit several other secondary responses that may contribute directly or indirectly to the growth and development. The present review summarized recent signs of progress on the functional properties of indole and its derivatives in different plant systems. The molecular mechanism involved in the defensive role played by indole as well as its’ derivative in the plants has also been explained. Furthermore, the perspectives of indole and its derivatives (natural or synthetic) in understanding the involvement of these compounds in diverse plants have also been discussed.

Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors

2019 ◽  
Vol 83 ◽  
pp. 520-525 ◽  
Author(s):  
Kuang-Feng Chu ◽  
Jen-Shin Song ◽  
Chiung-Tong Chen ◽  
Teng-Kuang Yeh ◽  
Tsung-Chih Hsieh ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Indole Derivatives ◽  
Sodium Dependent ◽  
Synthesis And Biological Evaluation
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