The Influence of Allopurinol on Renal Deterioration in Familial Nepropathy Associated with Hyperuricemia (FNAH)

1995 ◽  
pp. 61-64 ◽  
Author(s):  
María Eugenia Miranda
Keyword(s):  
Renal Deterioration

Outcomes of diuretic use in pre-dialysis CKD patients with moderate renal deterioration attending tertiary care referral center

2017 ◽  
Vol 21 (6) ◽  
pp. 1011-1023 ◽  
Author(s):  
Yusra Habib Khan ◽  
Azmi Sarriff ◽  
Azreen Syazril Adnan ◽  
Amer Hayat Khan ◽  
Tauqeer Hussain Mallhi
Keyword(s):  
Tertiary Care ◽  
Renal Deterioration ◽  
Referral Center

scholarly journals Effects of Tolvaptan on Oxidative Stress in ADPKD: A Molecular Biological Approach

2022 ◽  
Vol 11 (2) ◽  
pp. 402
Author(s):  
Matteo Rigato ◽  
Gianni Carraro ◽  
Irene Cirella ◽  
Silvia Dian ◽  
Valentina Di Di Vico ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Molecular Mechanisms ◽  
Kinase Activity ◽  
Rho Kinase ◽  
Renal Deterioration ◽  
Deterioration Rate ◽  
Function Loss ◽  
State Marker ◽  
Molecular Biological Approach

Autosomal dominant polycystic disease (ADPKD) is the most frequent monogenic kidney disease. It causes progressive renal failure, endothelial dysfunction, and hypertension, all of which are strictly linked to oxidative stress (OxSt). Treatment with tolvaptan is known to slow the renal deterioration rate, but not all the molecular mechanisms involved in this effect are well-established. We evaluated the OxSt state in untreated ADPKD patients compared to that in tolvaptan-treated ADPKD patients and healthy subjects. OxSt was assessed in nine patients for each group in terms of mononuclear cell p22phox protein expression, NADPH oxidase key subunit, MYPT-1 phosphorylation state, marker of Rho kinase activity (Western blot) and heme oxygenase (HO)-1, induced and protective against OxSt (ELISA). p22phox protein expression was higher in untreated ADPKD patients compared to treated patients and controls: 1.42 ± 0.11 vs. 0.86 ± 0.15 d.u., p = 0.015, vs. 0.53 ± 0.11 d.u., p < 0.001, respectively. The same was observed for phosphorylated MYPT-1: 0.96 ± 0.28 vs. 0.68 ± 0.09 d.u., p = 0.013 and vs. 0.47 ± 0.13 d.u., p < 0.001, respectively, while the HO-1 expression of untreated patients was significantly lower compared to that of treated patients and controls: 5.33 ± 3.34 vs. 2.08 ± 0.79 ng/mL, p = 0.012, vs. 1.97 ± 1.22 ng/mL, p = 0.012, respectively. Tolvaptan-treated ADPKD patients have reduced OxSt levels compared to untreated patients. This effect may contribute to the slowing of renal function loss observed with tolvaptan treatment.

scholarly journals A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yasuyuki Nakada ◽  
Nobuo Tsuboi ◽  
Yasuto Takahashi ◽  
Hiraku Yoshida ◽  
Yoriko Hara ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Indirect Immunofluorescence ◽  
Crescentic Glomerulonephritis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Basement Membranes ◽  
Proteinase 3 ◽  
Renal Deterioration ◽  
Membranous Glomerulopathy ◽  
Immunosorbent Assays ◽  
The Relationship

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.

Acute kidney injury in pregnancy

2018 ◽  
Author(s):  
Duska Dragun ◽  
Björn Hegner
Keyword(s):  
Acute Kidney Injury ◽  
Placental Abruption ◽  
Hyperemesis Gravidarum ◽  
Kidney Injury ◽  
Late Pregnancy ◽  
Bleeding Complications ◽  
Volume Depletion ◽  
Cortical Necrosis ◽  
Renal Deterioration ◽  
Obstetric Haemorrhage

Any kind of acute renal deterioration that occurs in young women may, besides typical pregnancy-related disorders, account for pregnancy-related acute kidney injury (PR-AKI). Incidence of PR-AKI is continuously decreasing, yet still represents a significant cause of fetomaternal morbidity and mortality. Hyperemesis gravidarum causing volume depletion and septic shock with renal cortical necrosis upon septic abortion are major causes of PR-AKI during early pregnancy. Pre-eclampsia and bleeding complications associated with placental abruption or other causes of obstetric haemorrhage are responsible for the majority of cases during late pregnancy (after week 35) and puerperium. Haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura disorders are less common than pre-eclampsia, yet represent a diagnostic and therapeutic challenge due to similar features to severe pre-eclampsia cases.

Commentary - Renal deterioration in children and adults with spina bifida: Fact, fiction or both?

2020 ◽  
Vol 16 (2) ◽  
pp. 178-179
Author(s):  
Kirsten Simmons ◽  
Rohit Tejwani ◽  
Jonathan C. Routh
Keyword(s):  
Spina Bifida ◽  
Renal Deterioration

scholarly journals Increased Risk of Renal Deterioration Associated with Low e-GFR in Type 2 Diabetes Mellitus Only in Albuminuric Subjects

2009 ◽  
Vol 48 (9) ◽  
pp. 657-663 ◽  
Author(s):  
Shu Meguro ◽  
Toshikatsu Shigihara ◽  
Yusuke Kabeya ◽  
Masuomi Tomita ◽  
Yoshihito Atsumi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Deterioration ◽  
Increased Risk

scholarly journals MP12: CRYOGLOBULINEMIA IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)– A CASE REPORT AND REVIEW OF LITERATURE OF RENAL INVOLVEMENT IN CLL

2016 ◽  
Vol 64 (3) ◽  
pp. 809.2-810
Author(s):  
S Arora ◽  
D Levitan ◽  
N Regmi ◽  
G Sidhu ◽  
R Gupta ◽  
...  
Keyword(s):  
Early Stage ◽  
Renal Involvement ◽  
Lymphocytic Leukemia ◽  
Renal Deterioration ◽  
Rare Manifestation ◽  
Pubmed Search ◽  
Search Data ◽  
Secretory Phenotype ◽  
Weak Expression ◽  
Kidney Impairment

Purpose of StudyWe report a case of early stage CLL that caused cryoglobulinemia-related glomerulonephritis (MPGN). This prompted a literature review to identify the incidence and causes of renal disease in patients with CLL.Methods UsedUsing a PUBMED search data of cases reported between 1990 and 2014, we selected cases with the following criteria:(1) Clinical and hematologic diagnosis of CLL(2) Evidence of renal insufficiency in association with CLL in the absence of other causes for proteinuria.Summary of ResultsReview of the literature revealed that 50 cases of CLL-related nephropathy have been reported, commonly with the nephrotic syndrome (MPGN). IHC staining of the renal biopsies of these patients revealed mostly monoclonal IgG kappa. Many of these were low stage CLL patients and had not been treated. In 68% the renal complications first developed years after the CLL was diagnosed. Most importantly, 65% of all patients' nephropathies responded completely to anti-CLL therapy.ConclusionsWe report a rare manifestation of a secretory type of CLL with cryoglobulinemic vasculitis; leading to rapid renal deterioration needing dialysis. Renal damage can be a sequela of early-stage CLL due to its secretory phenotype. Timely recognition of kidney impairment and routine testing of serum or urine proteins in CLL patients is warranted to detect its early transition to a secretory phenotype. We believe that therapeutic intervention in early stage CLL may be effective in the preservation of renal function by removing the secretory phenotypic clone.Abstract MP12 Figure 1IFE of cryoglobulins involving the kidney in our patient; predominantly IgG and kappa light chain (A&D) with weak expression of IgM lambda (B&D).

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