Central Nervous System Neuron-Glia co-Culture Models and Application to Neuroprotective Agents

2017 ◽  
pp. 63-80 ◽  
Author(s):  
Stephen D. Skaper ◽  
Laura Facci
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuroprotective Agents ◽  
Central Nervous System Neuron ◽  
Culture Models

scholarly journals Neuroprotective Aspects of Cannabinoid Compounds

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Molecular Mechanisms ◽  
Reliable Data ◽  
Protective Effects ◽  
Neuroprotective Agents ◽  
Beneficial Effects ◽  
Cannabinoid Compounds ◽  
The Central Nervous System ◽  
Effective Use

The accumulation of reliable data on the effects of cannabinoids is essential for understanding their possible beneficial effects on the central nervous system (CNS). Investigating individual substances along with the action of different combinations may show new possibilities for cannabinoids as neuroprotective agents. The data collected so far reveals the complexity of the mechanism of cannabinoids action on CNS, and even more complex and poorly understood are the effects when combined. Moreover, combining cannabinoids with different drugs and chemicals may lead to a decrease in beneficial effects. These characteristics of their action emphasize the complexity of the molecular mechanisms of neuroprotection and the lack of reliable information that may contribute to the safe and effective use of cannabinoids as medicines with valuable neuroprotective properties. The current brief review summarizes present data related to the protective effects of some cannabinoids on CNS and possible mechanisms involved in cannabinoid-mediated neuroprotection.

Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

2005 ◽  
Vol 70 (11) ◽  
pp. 1642-1652 ◽  
Author(s):  
Hailin Zheng ◽  
Moussa B.H. Youdim ◽  
Lev M. Weiner ◽  
Mati Fridkin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amino Acid ◽  
Neuroprotective Agents

Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching

2017 ◽  
Vol 31 (9) ◽  
pp. 1277-1295 ◽  
Author(s):  
Anne Faust ◽  
Apoorva Kandakatla ◽  
Yolandi van der Merwe ◽  
Tanchen Ren ◽  
Luai Huleihel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Extracellular Matrix ◽  
Nervous System ◽  
Urinary Bladder ◽  
Hippocampal Neuron ◽  
Neurite Growth ◽  
Primary Hippocampal Neuron ◽  
Central Nervous System Neuron ◽  
Urinary Bladder Matrix ◽  
Matrix Bound

Central nervous system neurons often degenerate after trauma due to the inflammatory innate immune response to injury, which can lead to neuronal cell death, scarring, and permanently lost neurologic function. Extracellular matrix bioscaffolds, derived by decellularizing healthy tissues, have been widely used in both preclinical and clinical studies to promote positive tissue remodeling, including neurogenesis, in numerous tissues, with extracellular matrix from homologous tissues often inducing more positive responses. Extracellular matrix hydrogels are liquid at room temperature and enable minimally invasive extracellular matrix injections into central nervous system tissues, before gelation at 37℃. However, few studies have analyzed how extracellular matrix hydrogels influence primary central nervous system neuron survival and growth, and whether central nervous system and non-central nervous system extracellular matrix specificity is critical to neuronal responses. Urinary bladder extracellular matrix hydrogels increase both primary hippocampal neuron survival and neurite growth to similar or even greater extents, suggesting extracellular matrix from non-homologous tissue sources, such as urinary bladder matrix-extracellular matrix, may be a more economical and safer alternative to developing central nervous system extracellular matrices for central nervous system applications. Additionally, we show matrix-bound vesicles derived from urinary bladder extracellular matrix are endocytosed by hippocampal neurons and positively regulate primary hippocampal neuron neurite growth. Matrix-bound vesicles carry protein and RNA cargos, including noncoding RNAs and miRNAs that map to the human genome and are known to regulate cellular processes. Thus, urinary bladder matrix-bound vesicles provide natural and transfectable cargoes which offer new experimental tools and therapeutic applications to study and treat central nervous system neuron injury.

scholarly journals Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury

Molecules ◽  
2010 ◽  
Vol 15 (9) ◽  
pp. 6598-6618 ◽  
Author(s):  
Emma Thornton ◽  
Jenna M Ziebell ◽  
Anna V Leonard ◽  
Robert Vink
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Injury ◽  
Neuroprotective Agents ◽  
Receptor Antagonists ◽  
Kinin Receptor

Cell Culture Models of Oxidative Stress and Injury in the Central Nervous System

2005 ◽  
Vol 2 (1) ◽  
pp. 73-89 ◽  
Author(s):  
Marina Aksenova ◽  
Michael Aksenov ◽  
Charles Mactutus ◽  
Rosemarie Booze
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Cell Culture ◽  
Nervous System ◽  
Culture Models ◽  
The Central Nervous System ◽  
Cell Culture Models
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