scholarly journals Perspectives on Assurance Case Development for Retinal Disease Diagnosis Using Deep Learning

Author(s):  
Chiara Picardi ◽  
Ibrahim Habli
PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261698
Author(s):  
Mohsin Raza ◽  
Khuram Naveed ◽  
Awais Akram ◽  
Nema Salem ◽  
Amir Afaq ◽  
...  

In this era, deep learning-based medical image analysis has become a reliable source in assisting medical practitioners for various retinal disease diagnosis like hypertension, diabetic retinopathy (DR), arteriosclerosis glaucoma, and macular edema etc. Among these retinal diseases, DR can lead to vision detachment in diabetic patients which cause swelling of these retinal blood vessels or even can create new vessels. This creation or the new vessels and swelling can be analyzed as biomarker for screening and analysis of DR. Deep learning-based semantic segmentation of these vessels can be an effective tool to detect changes in retinal vasculature for diagnostic purposes. This segmentation task becomes challenging because of the low-quality retinal images with different image acquisition conditions, and intensity variations. Existing retinal blood vessels segmentation methods require a large number of trainable parameters for training of their networks. This paper introduces a novel Dense Aggregation Vessel Segmentation Network (DAVS-Net), which can achieve high segmentation performance with only a few trainable parameters. For faster convergence, this network uses an encoder-decoder framework in which edge information is transferred from the first layers of the encoder to the last layer of the decoder. Performance of the proposed network is evaluated on publicly available retinal blood vessels datasets of DRIVE, CHASE_DB1, and STARE. Proposed method achieved state-of-the-art segmentation accuracy using a few number of trainable parameters.


2020 ◽  
Vol 15 ◽  
Author(s):  
Deeksha Saxena ◽  
Mohammed Haris Siddiqui ◽  
Rajnish Kumar

Background: Deep learning (DL) is an Artificial neural network-driven framework with multiple levels of representation for which non-linear modules combined in such a way that the levels of representation can be enhanced from lower to a much abstract level. Though DL is used widely in almost every field, it has largely brought a breakthrough in biological sciences as it is used in disease diagnosis and clinical trials. DL can be clubbed with machine learning, but at times both are used individually as well. DL seems to be a better platform than machine learning as the former does not require an intermediate feature extraction and works well with larger datasets. DL is one of the most discussed fields among the scientists and researchers these days for diagnosing and solving various biological problems. However, deep learning models need some improvisation and experimental validations to be more productive. Objective: To review the available DL models and datasets that are used in disease diagnosis. Methods: Available DL models and their applications in disease diagnosis were reviewed discussed and tabulated. Types of datasets and some of the popular disease related data sources for DL were highlighted. Results: We have analyzed the frequently used DL methods, data types and discussed some of the recent deep learning models used for solving different biological problems. Conclusion: The review presents useful insights about DL methods, data types, selection of DL models for the disease diagnosis.


2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098284
Author(s):  
Tingting Qiao ◽  
Simin Liu ◽  
Zhijun Cui ◽  
Xiaqing Yu ◽  
Haidong Cai ◽  
...  

Objective To construct deep learning (DL) models to improve the accuracy and efficiency of thyroid disease diagnosis by thyroid scintigraphy. Methods We constructed DL models with AlexNet, VGGNet, and ResNet. The models were trained separately with transfer learning. We measured each model’s performance with six indicators: recall, precision, negative predictive value (NPV), specificity, accuracy, and F1-score. We also compared the diagnostic performances of first- and third-year nuclear medicine (NM) residents with assistance from the best-performing DL-based model. The Kappa coefficient and average classification time of each model were compared with those of two NM residents. Results The recall, precision, NPV, specificity, accuracy, and F1-score of the three models ranged from 73.33% to 97.00%. The Kappa coefficient of all three models was >0.710. All models performed better than the first-year NM resident but not as well as the third-year NM resident in terms of diagnostic ability. However, the ResNet model provided “diagnostic assistance” to the NM residents. The models provided results at speeds 400 to 600 times faster than the NM residents. Conclusion DL-based models perform well in diagnostic assessment by thyroid scintigraphy. These models may serve as tools for NM residents in the diagnosis of Graves’ disease and subacute thyroiditis.


Author(s):  
Jinyuan Dang ◽  
Hu Li ◽  
Kai Niu ◽  
Zhiyuan Xu ◽  
Jianhao Lin ◽  
...  

2021 ◽  
Vol 464 ◽  
pp. 364-393
Author(s):  
Hongfeng Li ◽  
Yini Pan ◽  
Jie Zhao ◽  
Li Zhang

2017 ◽  
Vol 25 (3) ◽  
pp. 435-499 ◽  
Author(s):  
Ewen Denney ◽  
Ganesh Pai

2021 ◽  
Vol 11 (2) ◽  
pp. 760
Author(s):  
Yun-ji Kim ◽  
Hyun Chin Cho ◽  
Hyun-chong Cho

Gastric cancer has a high mortality rate worldwide, but it can be prevented with early detection through regular gastroscopy. Herein, we propose a deep learning-based computer-aided diagnosis (CADx) system applying data augmentation to help doctors classify gastroscopy images as normal or abnormal. To improve the performance of deep learning, a large amount of training data are required. However, the collection of medical data, owing to their nature, is highly expensive and time consuming. Therefore, data were generated through deep convolutional generative adversarial networks (DCGAN), and 25 augmentation policies optimized for the CIFAR-10 dataset were implemented through AutoAugment to augment the data. Accordingly, a gastroscopy image was augmented, only high-quality images were selected through an image quality-measurement method, and gastroscopy images were classified as normal or abnormal through the Xception network. We compared the performances of the original training dataset, which did not improve, the dataset generated through the DCGAN, the dataset augmented through the augmentation policies of CIFAR-10, and the dataset combining the two methods. The dataset combining the two methods delivered the best performance in terms of accuracy (0.851) and achieved an improvement of 0.06 over the original training dataset. We confirmed that augmenting data through the DCGAN and CIFAR-10 augmentation policies is most suitable for the classification model for normal and abnormal gastric endoscopy images. The proposed method not only solves the medical-data problem but also improves the accuracy of gastric disease diagnosis.


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