Brain Plasticity, Learning and Memory

2020 ◽  
pp. 39-42
Author(s):  
Derek Burke
Author(s):  
Jocelyn Widagdo ◽  
Justin J.-L. Wong ◽  
Victor Anggono

2019 ◽  
pp. 1-40
Author(s):  
Risto Näätänen ◽  
Teija Kujala ◽  
Gregory Light

In this chapter, the mismatch negativity (MMN) event-related brain potential is introduced. MMN is an automatic response to any sound change generated primarily in auditory and frontal cortices, reflecting auditory change detection and discrimination accuracy. Analogous responses have also been found in other sensory modalities. MMN can, for example, index improvement of sound discrimination as a function of learning or recovery. Consistent with this, MMN appears to index general brain plasticity, essential for learning and memory, and to reflect different cognitive brain disorders. It is elicited irrespective of the direction of attention, being, therefore, a feasible tool for investigating even inattentive participants, such as sleeping infants or comatose patients.


PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20678 ◽  
Author(s):  
Tamar Blumenfeld-Katzir ◽  
Ofer Pasternak ◽  
Michael Dagan ◽  
Yaniv Assaf

2020 ◽  
Vol 4 ◽  
pp. 239821282097980
Author(s):  
Julie-Myrtille Bourgognon ◽  
Jonathan Cavanagh

Cytokines are proteins secreted in the central nervous system by neurons, microglia, astrocytes and infiltrating peripheral immune cells under physiological and pathological conditions. Over the last 20 years, a growing number of reports have investigated the effects of these molecules on brain plasticity. In this review, we describe how the key cytokines interleukin 1β, interleukin 6 and tumour necrosis factor α were found to support long-term plasticity and learning and memory processes in physiological conditions. In contrast, during inflammation where cytokines levels are elevated such as in models of brain injury or infection, depression or neurodegeneration, the effects of cytokines are mostly detrimental to memory mechanisms, associated behaviours and homeostatic plasticity.


2015 ◽  
Vol 13 ◽  
pp. 39
Author(s):  
Diogo O. Souza

Symposium 3 - Science Education “Leopoldo de Meis” Chair: Wagner Seixas da Silva, Universidade Federal do Rio de JaneiroAbstract:In this talk we will discuss the relevance of the brain neurobiology in the student learning/formal evaluation processes in the classroom. It is important to emphasize that the students “are alive” before and after each class. It means that their brains are receiving a massive amount of environmental stimuli, which are processed by the complex cerebral circuitry involved in learning and memory processes. These stimuli interact with previous memories, which adapt to the new stimuli and are adjusted by them. These constant new interactions induce brain plasticity, changing the behavior in such way that a student that leaves the class is not exactly the same that will enter in the next class. At the same time, when students are in the class, what they are learning is not only (even nor the most relevant) what the teacher is trying to teach. These “anonymous” experiences may impact the brain stronger than the teacher’s information. The neurobiological bases of all these interactions are nowadays being more and more revealed; unfortunately this new scientific knowledge is still not integrated in most of the class activities. The idea of this talk is to contribute for the discussion on how important is to incorporate this new scientific information to the current evaluation methods. Importantly, the aim here is not to transform all teachers in neuroscientists, but only motivate the school community for accepting that we learn with the brain and, consequently, the neurobiology of learning and memory should be valorized in formal evaluation of learning. Finally, it is important in terms of evaluation not consider strictly the answers to the question raised in an exam, but what happened within the time between a previous classroom and the time in which the exam is applied.


2018 ◽  
Vol 7 ◽  
Author(s):  
Julien Bensalem ◽  
Stéphanie Dudonné ◽  
David Gaudout ◽  
Laure Servant ◽  
Frédéric Calon ◽  
...  

AbstractAgeing is characterised by memory deficits, associated with brain plasticity impairment. Polyphenols from berries, such as flavan-3-ols, anthocyanins, and resveratrol, have been suggested to modulate synaptic plasticity and cognitive processes. In the present study we assessed the preventive effect of a polyphenol-rich extract from grape and blueberry (PEGB), with high concentrations of flavonoids, on age-related cognitive decline in mice. Adult and aged (6 weeks and 16 months) mice were fed a PEGB-enriched diet for 14 weeks. Learning and memory were assessed using the novel object recognition and Morris water maze tasks. Brain polyphenol content was evaluated with ultra-high-performance LC-MS/MS. Hippocampal neurotrophin expression was measured using quantitative real-time PCR. Finally, the effect of PEGB on adult hippocampal neurogenesis was assessed by immunochemistry, counting the number of cells expressing doublecortin and the proportion of cells with dendritic prolongations. The combination of grape and blueberry polyphenols prevented age-induced learning and memory deficits. Moreover, it increased hippocampal nerve growth factor (Ngf) mRNA expression. Aged supplemented mice displayed a greater proportion of newly generated neurons with prolongations than control age-matched mice. Some of the polyphenols included in the extract were detected in the brain in the native form or as metabolites. Aged supplemented mice also displayed a better survival rate. These data suggest that PEGB may prevent age-induced cognitive decline. Possible mechanisms of action include a modulation of brain plasticity. Post-treatment detection of phenolic compounds in the brain suggests that polyphenols may act directly at the central level, while they can make an impact on mouse survival through a potential systemic effect.


2010 ◽  
Vol 34 (8) ◽  
pp. S18-S18
Author(s):  
Wei Jiang ◽  
Enyi Wen ◽  
Min Gong ◽  
Yang Bi ◽  
Xiaojuan Zhang ◽  
...  

GeroPsych ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 67-76
Author(s):  
Grace C. Niu ◽  
Patricia A. Arean

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.


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