Regulation of Antioxidant Enzyme Levels in Rat Brain

2021 ◽  
pp. 21-26
Author(s):  
Sandhyarani Guggilla ◽  
Middela Karthik ◽  
Boini Shylendra
Keyword(s):  
Rat Brain ◽  
Antioxidant Enzyme

scholarly journals Effects of low and high deprenyl dose on antioxidant enzyme activities in the adult rat brain

2017 ◽  
Vol 36 (01) ◽  
pp. 83-90 ◽  
Author(s):  
Maria Lalkovicova ◽  
Frantiska Horvathova ◽  
Igor Sulla ◽  
Jozef Mihalik ◽  
Viera Danielisova
Keyword(s):  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Antioxidant Enzyme Activities ◽  
Adult Rat ◽  
Adult Rat Brain

Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures

2005 ◽  
Vol 48 (7) ◽  
pp. 965-974 ◽  
Author(s):  
Jean-Bernard Dietrich ◽  
Aude Mangeol ◽  
Marie-Odile Revel ◽  
Claude Burgun ◽  
Dominique Aunis ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Enzyme Activity ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Reactive Oxygen ◽  
Brain Structures ◽  
Antioxidant Enzyme Activity ◽  
Oxygen Species ◽  
Cocaine Administration

Possible supportive effects of co-dergocrine mesylate on antioxidant enzyme systems in aged rat brain

1998 ◽  
Vol 8 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Eser Yıldırım Sözmen ◽  
Lütfiye Kanit ◽  
Fatma Z Kutay ◽  
Nuran İ Hariri
Keyword(s):  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Aged Rat ◽  
Enzyme Systems

scholarly journals Effects of Zataria multiflora Extract and Carvacrol on Doxorubicin-Induced Oxidative Stress in Rat Brain

2018 ◽  
Vol 24 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Reza Mohebbati ◽  
Mohammad Jalili-Nik ◽  
Maryam Paseban ◽  
Mohammad Naser Shafei ◽  
Abolfazl Khajavirad Rad
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Antioxidant Defense System ◽  
Male Rats ◽  
Control Group ◽  
Hydroalcoholic Extract ◽  
Zataria Multiflora ◽  
Significant Difference ◽  
Thiol Content

Background: Due to the antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in various problems and the prominent role of the ROS in neurotoxicity induced by Doxorubicin (DOX), this study was designed to investigate the effects of ZM hydroalcoholic extract and CAR on DOX-induced oxidative stress in rat brain Methods: 24 male rats were randomly divided into four groups including: 1)Control ,2)Doxorubicin (DOX) that received DOX via a tail vein on the first day of the study, 3,4) ZM+DOX and CAR+DOX which received ZM and CAR by gavage for 28 consecutive days. Brain tissue removed for redox markers evaluation. Results: MDA level in the DOX group was significantly increased compared to control group while in treated groups did not show any significant changes in comparison with the DOX group. Also, Thiol content in DOX group showed significant reduction compared to control group. Thiol contents in treated groups showed no significant difference compared to DOX group. Catalase (CAT) activity, an antioxidant enzyme, in the DOX group were significantly decreased compared to control group and increased in treated rats in comparison with the DOX group. Activity of Superoxide dismutase (SOD), an antioxidant enzyme, in the DOX group was significantly reduced compared to control group and increased in treated rats in comparison with the DOX group. Conclusion: The present study showed that ZM hydroalcoholic extract and CAR could inhibit DOX induced oxidative stress of the brain mainly with effect on the enzymatic antioxidant defense system.

Regional difference of ROS generation, lipid peroxidaton, and antioxidant enzyme activity in rat brain and their dietary modulation

1999 ◽  
Vol 22 (4) ◽  
pp. 361-366 ◽  
Author(s):  
Bong Sook Baek ◽  
Hyun Joo Kwon ◽  
Kyoung Hee Lee ◽  
Mi Ae Yoo ◽  
Kyu Won Kim ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Regional Difference ◽  
Antioxidant Enzyme Activity ◽  
Ros Generation ◽  
Dietary Modulation

scholarly journals THE EFFECT OF INTERMITTENT HYPOBARIC HYPOXIA ON OXIDATIVE STRESS STATUS AND ANTIOXIDANT ENZYMES ACTIVITY IN RAT BRAIN

2019 ◽  
Vol 1 (2) ◽  
pp. 46-51 ◽  
Author(s):  
Syarifah Dewi ◽  
Wawan Mulyawan ◽  
Septelia Inawati Wanandi ◽  
Mohamad Sadikin
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Hypobaric Hypoxia ◽  
Specific Activity ◽  
Barometric Pressure ◽  
Control Group ◽  
Exposure Group ◽  
Group I ◽  
Oxidative Stress Status

Background: High altitude can cause hypobaric hypoxia (HH), resulted from the lower barometric pressure and hence partial pressure of oxygen. Hypoxia can lead to a lot of deleterious molecular and cellular changes, such as generation of free radicals or reactive oxygen species (ROS). Increasing of ROS can cause oxidative stress if the antioxidant enzyme does not increase simultaneously. Oxidative damage in brain has toxic effect on cognitive functions.Objective: In this study, we investigate effect of acute intermittent HH on oxidative stress and antioxidant enzyme activity in rat brain.Method: Wistar rats divided into 5 groups, consisting control group and four experimental groups which treated to HH. Rats were exposed to simulated HH equivalent to 35.000 feet in hypobaric chamber for 1 minute, repeated once a week.Results: Level of malondialdehyde and carbonyl in rat brain under acute HH increased at HH exposure (group I) compare to control group. These levels decreased afterward at intermittent HH exposure (group II-IV). Specific activity of superoxide dismutase (SOD) shows increasing level at intermittent HH exposure, especially group IV was increasing of SOD level significantly. The increasing pattern of specific activity of catalase was inversely from SOD pattern, but it still has higher activity in intermittent HH compare to control group.Conclusion: Brain tissue seems to be able to perform an adequate adaptive response to hypobaric hypoxia after the training, shown by its significantly decreased MDA and carbonyl level and also increased specific activity of SOD and catalase.

Sign in / Sign up

Export Citation Format

Share Document