Regional difference of ROS generation, lipid peroxidaton, and antioxidant enzyme activity in rat brain and their dietary modulation

1999 ◽  
Vol 22 (4) ◽  
pp. 361-366 ◽  
Author(s):  
Bong Sook Baek ◽  
Hyun Joo Kwon ◽  
Kyoung Hee Lee ◽  
Mi Ae Yoo ◽  
Kyu Won Kim ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Regional Difference ◽  
Antioxidant Enzyme Activity ◽  
Ros Generation ◽  
Dietary Modulation

Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures

2005 ◽  
Vol 48 (7) ◽  
pp. 965-974 ◽  
Author(s):  
Jean-Bernard Dietrich ◽  
Aude Mangeol ◽  
Marie-Odile Revel ◽  
Claude Burgun ◽  
Dominique Aunis ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Enzyme Activity ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Reactive Oxygen ◽  
Brain Structures ◽  
Antioxidant Enzyme Activity ◽  
Oxygen Species ◽  
Cocaine Administration

Antioxidant Enzyme Levels Inversely Covary with Hearing Loss After Amikacin Treatment

2003 ◽  
Vol 14 (03) ◽  
pp. 134-143 ◽  
Author(s):  
James J. Klemens ◽  
Robert P. Meech ◽  
Larry F. Hughes ◽  
Satu Somani ◽  
Kathleen C.M. Campbell
Keyword(s):  
Hearing Loss ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Antioxidant Enzyme Activity ◽  
Control Group ◽  
Glutathione S Transferase ◽  
Brainstem Response ◽  
The Difference

This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of aminoglycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was performed prior to the first injection and again before sacrifice, 28 days later. Cochleae were harvested and superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase activities and malondialdehyde levels were measured. All antioxidant enzymes had significantly lower activity in the amikacin group (p ≤ 0.05) than in the control group. The difference in cochlear antioxidant enzyme activity between groups inversely correlated significantly with the change in ABR thresholds. The greatest correlation was for the high frequencies, which are most affected by aminoglycosides. This study demonstrates that antioxidant enzyme activity and amikacin-induced hearing loss significantly covary.

Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression

Life Sciences ◽  
2002 ◽  
Vol 71 (11) ◽  
pp. 1303-1312 ◽  
Author(s):  
Jérôme Busserolles ◽  
Wioletta Zimowska ◽  
Edmond Rock ◽  
Yves Rayssiguier ◽  
Andrzej Mazur
Keyword(s):  
Gene Expression ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Antioxidant Enzyme Activity ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose
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