Dietary Proteins: Functions, Health Benefits and Healthy Aging

2021 ◽  
pp. 3-37
Author(s):  
Khetan Shevkani ◽  
Shivani Chourasia
Keyword(s):  
Healthy Aging ◽  
Health Benefits ◽  
Dietary Proteins

scholarly journals Whole Fruits and Fruit Fiber Emerging Health Effects

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1833 ◽  
Author(s):  
Mark Dreher
Keyword(s):  
Health Effects ◽  
Successful Aging ◽  
Healthy Aging ◽  
Seborrheic Dermatitis ◽  
Health Benefits ◽  
Well Being ◽  
Autism Spectrum ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Potential Health

Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. These potential health benefits include: protecting colonic gastrointestinal health (e.g., constipation, irritable bowel syndrome, inflammatory bowel diseases, and diverticular disease); promoting long-term weight management; reducing risk of cardiovascular disease, type 2 diabetes and metabolic syndrome; defending against colorectal and lung cancers; improving odds of successful aging; reducing the severity of asthma and chronic obstructive pulmonary disease; enhancing psychological well-being and lowering the risk of depression; contributing to higher bone mineral density in children and adults; reducing risk of seborrheic dermatitis; and helping to attenuate autism spectrum disorder severity. Low whole fruit intake represents a potentially more serious global population health threat than previously recognized, especially in light of the emerging research on whole fruit and fruit fiber health benefits.

scholarly journals Physical Activity Among Persons Aging with Mobility Disabilities: Shaping a Research Agenda

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Dori E. Rosenberg ◽  
Charles H. Bombardier ◽  
Jeanne M. Hoffman ◽  
Basia Belza
Keyword(s):  
Physical Activity ◽  
Research Agenda ◽  
Healthy Aging ◽  
Physical Activity Intervention ◽  
Health Benefits ◽  
Intervention Strategies ◽  
Mobility Disability ◽  
Aging Research ◽  
Present Evidence ◽  
Research Recommendations

With the aging of the baby boomer population and their accompanying burden of disease, future disability rates are expected to increase. This paper summarizes the state of the evidence regarding physical activity and aging for individuals with mobility disability and proposes a healthy aging research agenda for this population. Using a previously published framework, we present evidence in order to compile research recommendations in four areas focusing on older adults with mobility disability: (1) prevalence of physical activity, (2) health benefits of physical activity, (3) correlates of physical activity participation, and, (4) promising physical activity intervention strategies. Overall, findings show a dearth of research examining physical activity health benefits, correlates (demographic, psychological, social, and built environment), and interventions among persons aging with mobility disability. Further research is warranted.

scholarly journals Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan

GeroScience ◽  
2021 ◽  
Author(s):  
Chatrawee Duangjan ◽  
Sean P. Curran
Keyword(s):  
Caenorhabditis Elegans ◽  
Camellia Sinensis ◽  
Healthy Aging ◽  
Health Benefits ◽  
Normal Diet ◽  
Bioactive Molecules ◽  
Protective Effects ◽  
Oolong Tea ◽  
Age Related ◽  
Antioxidant Agents

AbstractTea polyphenols are widely considered as excellent antioxidant agents which can contribute to human health and longevity. However, the identification of the active biomolecules in complex tea extracts that promote health and longevity are not fully known. Here we used the nematode Caenorhabditis elegans to analyze the health benefits and longevity effects of Camellia sinensis oolong tea extracts (QFT, NFT, and CFT) and oolonghomobisflavan A and oolonghomobisflavan B, which are present in oolong tea extracts. Our results showed that oolong tea extracts and oolonghomobisflavans prolong lifespan and improved healthspan by curtailing the age-related decline in muscle activity and the accumulation of age pigment (lipofuscin). We found that the lifespan and healthspan promoting effects of oolong tea extracts and oolonghomobisflavans were positively correlated with the stress resistance via DAF-16/FOXO transcription factor. Furthermore, oolong tea extracts and oolonghomobisflavans displayed protective effects against Aβ- and polyQ-induced neuro/proteotoxicity. Overall, our study provides new evidence to support the health benefits of oolong tea and importantly identify oolonghomobisflavans as potent bioactive molecules that promote health when supplemented with a normal diet. As such, oolonghomobisflavans represent a valuable new class of compounds that promote healthy aging.

scholarly journals SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5196
Author(s):  
Nunzia D’Onofrio ◽  
Elisa Martino ◽  
Anna Balestrieri ◽  
Luigi Mele ◽  
Gianluca Neglia ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Regulatory Element ◽  
Antioxidant Properties ◽  
Health Benefits ◽  
Metabolic Reprogramming ◽  
Mitochondrial Energy Metabolism ◽  
Antiproliferative Effects ◽  
Ppar Γ ◽  
Hct 116 ◽  
Ht 29

Emerging strategies to improve healthy aging include dietary interventions as a tool to promote health benefits and reduce the incidence of aging-related comorbidities. The health benefits of milk are also linked to its richness in betaines and short-chain acylcarnitines, which act synergistically in conferring anticancer, anti-inflammatory, and antioxidant properties. Whey, despite being a dairy by-product, still has a considerable content of bioactive betaines and acylcarnitines. Here, we investigated the anticancer properties of whey from Mediterranean water buffalo (Bubalus bubalis) milk by testing its antiproliferative effects in colorectal cancer (CRC) cells HT-29, HCT 116, LoVo and SW480. Results indicated that treatment with whey for 72 h inhibited cell proliferation (p < 0.001), induced cell cycle arrest, and apoptosis via caspase-3 activation, and modulated cell metabolism by limiting glucose uptake and interfering with mitochondrial energy metabolism with the highest effects observed in HT-29 and HCT 116 cells. At molecular level, these effects were accompanied by upregulation of sirtuin 3 (SIRT3) (p < 0.01) and peroxisome proliferator-activated receptor (PPAR)-γ expression (p < 0.001), and downregulation of lactate dehydrogenase A (LDHA) (p < 0.01), sterol regulatory-element binding protein 1 (SREBP1) (p < 0.05), and PPAR-α (p < 0.01). Transient SIRT3 gene silencing blocked the effects of whey on the LDHA, PPAR-γ, and PPAR-α protein expressions (p < 0.01) suggesting that the whey capacity of perturbating the metabolic homeostasis in CRC cell lines is mediated by SIRT3.

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

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