Stem Cell Applications in Corneal Regeneration and Wound Repair

2017 ◽  
pp. 213-255
Author(s):  
Steffi Matthyssen ◽  
Bert Van den Bogerd ◽  
Sorcha Ní Dhubhghaill ◽  
Carina Koppen ◽  
Nadia Zakaria
Keyword(s):  
Stem Cell ◽  
Wound Repair ◽  
Corneal Regeneration

Stem cell therapies for wound repair

2011 ◽  
pp. 552-567
Author(s):  
G.G. Gauglitz ◽  
M.G. Jeschke
Keyword(s):  
Stem Cell ◽  
Wound Repair ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Extracellular matrix plasticity as a driver of cell spreading

2020 ◽  
Vol 117 (42) ◽  
pp. 25999-26007
Author(s):  
Joshua M. Grolman ◽  
Philipp Weinand ◽  
David J. Mooney
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Wound Repair ◽  
Kinetic Monte Carlo ◽  
Cell Spreading ◽  
Cell Biophysics ◽  
Biological Processes ◽  
Kinetic Monte Carlo Simulations ◽  
Network Plasticity ◽  
And Migration

Mammalian cell morphology has been linked to the viscoelastic properties of the adhesion substrate, which is particularly relevant in biological processes such as wound repair and embryonic development where cell spreading and migration are critical. Plastic deformation, degradation, and relaxation of stress are typically coupled in biomaterial systems used to explore these effects, making it unclear which variable drives cell behavior. Here we present a nondegradable polymer architecture that specifically decouples irreversible creep from stress relaxation and modulus. We demonstrate that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility. Kinetic Monte Carlo simulations also show strong correlation with experimental cell spreading data as a function of the extracellular matrix (ECM) plasticity. Furthermore, plasticity regulates many ECM adhesion and remodeling genes. Altogether, these findings confirm a key role for matrix plasticity in stem cell biophysics, and we anticipate this will have ramifications in the design of biomaterials to enhance therapeutic applications of stem cells.

Stem Cell Spheres for Corneal Regeneration

2019 ◽  
pp. 299-316 ◽  
Author(s):  
Salim Ismail ◽  
Jennifer J. McGhee ◽  
Ye Li ◽  
Jeremy John Mathan ◽  
Jinny Jung Yoon ◽  
...  
Keyword(s):  
Stem Cell ◽  
Corneal Regeneration

Abstract 4229: Wound repair promotes ovarian cancer stem cell self-renewal

2010 ◽  
Author(s):  
Ilana Chefetz-Menaker ◽  
Noah Lebowitz ◽  
Paolomi Aldo ◽  
Ayesha Alvero ◽  
Jennie Holmberg ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Wound Repair ◽  
Self Renewal

Limbal Epithelial and Mesenchymal Stem Cell Therapy for Corneal Regeneration

2019 ◽  
Vol 45 (3) ◽  
pp. 265-277 ◽  
Author(s):  
Sachin Shukla ◽  
Swapna S Shanbhag ◽  
Fatemeh Tavakkoli ◽  
Shobhit Varma ◽  
Vivek Singh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Corneal Regeneration

Cox-2 inhibition potentiates mouse bone marrow stem cell engraftment and differentiation-mediated wound repair

Cytotherapy ◽  
2017 ◽  
Vol 19 (6) ◽  
pp. 756-770 ◽  
Author(s):  
Ramasatyaveni Geesala ◽  
Neha R. Dhoke ◽  
Amitava Das
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Wound Repair ◽  
Bone Marrow Stem Cell ◽  
Mouse Bone Marrow ◽  
Cell Engraftment ◽  
Cox 2 ◽  
Marrow Stem Cell

scholarly journals Counteracting stem cell expansion during wound repair

Cell Cycle ◽  
2013 ◽  
Vol 12 (3) ◽  
pp. 387-388 ◽  
Author(s):  
Hiroyuki Miyoshi ◽  
Thaddeus S. Stappenbeck
Keyword(s):  
Stem Cell ◽  
Cell Expansion ◽  
Wound Repair ◽  
Stem Cell Expansion

scholarly journals Possibilities of treating skin lesions in the graft versus host disease using the Pulsavac Plus wound repair system

2020 ◽  
Vol 7 (2) ◽  
pp. 112-114
Author(s):  
T. Z. Aliev ◽  
K. I. Kirgizov ◽  
T. S. Belysheva
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Wound Repair ◽  
Skin Lesions ◽  
Repair System ◽  
Hematopoietic Stem ◽  
Graft Versus Host

This article describes the experience of using the Pulsavac Plus debridement system for atraumatic treatment of the skin in one of the forms of graft versus host diseases after allogeneic hematopoietic stem cell transplantation.

Sign in / Sign up

Export Citation Format

Share Document