Multi-aspect Assessment and Classification of Porous Materials Designed for Tissue Engineering

2017 ◽  
pp. 22-32
Author(s):  
Małgorzata Przytulska ◽  
Juliusz L. Kulikowski
Keyword(s):  
Tissue Engineering ◽  
Porous Materials

Hydrogel-Based Bioinks for Three-Dimensional Bioprinting: Patent Analysis

2021 ◽  
Vol 7 (1) ◽  
pp. 3
Author(s):  
Ahmed Fatimi
Keyword(s):  
Tissue Engineering ◽  
Detailed Analysis ◽  
State Of The Art ◽  
Three Dimensional ◽  
Patent Analysis ◽  
The State ◽  
Driving Factors ◽  
3D Bioprinting ◽  
Preparation Methods

There are a variety of hydrogel-based bioinks commonly used in three-dimensional bioprinting. In this study, in the form of patent analysis, the state of the art has been reviewed by introducing what has been patented in relation to hydrogel-based bioinks. Furthermore, a detailed analysis of the patentability of the used hydrogels, their preparation methods and their formulations, as well as the 3D bioprinting process using hydrogels, have been provided by determining publication years, jurisdictions, inventors, applicants, owners, and classifications. The classification of patents reveals that most inventions intended for hydrogels used as materials for prostheses or for coating prostheses are characterized by their function or properties Knowledge clusters and expert driving factors show that biomaterials, tissue engineering, and biofabrication research is concentrated in the most patents.

Classification of the properties of porous materials

1986 ◽  
Vol 25 (12) ◽  
pp. 1006-1010
Author(s):  
P. A. Vityaz' ◽  
V. K. Sheleg ◽  
V. M. Kaptsevich ◽  
V. V. Savich ◽  
A. N. Sorokina
Keyword(s):  
Porous Materials

scholarly journals Investigation of the dispersion processes of composite colloidal capillary-porous materials

2019 ◽  
pp. 21-25
Author(s):  
Zh.O. Petrova ◽  
V.M. Vyshnievskyi ◽  
Yu.P. Novikova ◽  
A.I. Petrov
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
Porous Materials ◽  
Material Flow ◽  
Maximum Yield ◽  
Flow Through ◽  
The Impact ◽  
First Time ◽  
Brittle State

The technology of drying colloidal capillary-porous materials to a final humidity of 6-8%, developed at the Institute of Technical Thermophysics of the NAS of Ukraine, allowed to obtain a brittle state, in which it is possible to grind this product to small particles. The most suitable for industrial grinding of the dried composite colloidal capillary-porous materials is the impact method, because when wiping and crushing the material has accumulated, stuck to the working surface. Powders are characterized by one pronounced maximum corresponding to the particle size of the powder of 0,16 mm. As the rotation speed of the shredder rotor changes, the particle size distribution of 0,16 mm increases by reducing the larger particles. The amount of powder thus obtained is directly proportional to the speed of rotation of the rotor. The study of the dispersion and classification of functional powders showed that all powders have the largest particle size of 0,16 mm. The maximum yield of this fraction is 70% and the lowest is 40%. The structural-mechanical characteristics of powders from composite colloidal capillary-porous materials were investigated for the first time.  Characteristics of different fractions were determined by such parameters as bulk density, vibration density, angle of natural slope, speed of material flow through the funnel and others. Studies to determine the structural and mechanical properties of functional powders have shown that they can be attributed to more bulk powders, as opposed to highly bound monopowders.  Creating compositions improves their structural and mechanical properties.

scholarly journals Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors

Bone Research ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Daniele Zuncheddu ◽  
Elena Della Bella ◽  
Andrea Schwab ◽  
Dalila Petta ◽  
Gaia Rocchitta ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Quality Control ◽  
General Introduction ◽  
Musculoskeletal Tissue ◽  
Minimal Invasiveness ◽  
Matrix Deposition ◽  
Novel Technology ◽  
Further Development

AbstractTissue engineering is rapidly progressing toward clinical application. In the musculoskeletal field, there has been an increasing necessity for bone and cartilage replacement. Despite the promising translational potential of tissue engineering approaches, careful attention should be given to the quality of developed constructs to increase the real applicability to patients. After a general introduction to musculoskeletal tissue engineering, this narrative review aims to offer an overview of methods, starting from classical techniques, such as gene expression analysis and histology, to less common methods, such as Raman spectroscopy, microcomputed tomography, and biosensors, that can be employed to assess the quality of constructs in terms of viability, morphology, or matrix deposition. A particular emphasis is given to standards and good practices (GXP), which can be applicable in different sectors. Moreover, a classification of the methods into destructive, noninvasive, or conservative based on the possible further development of a preimplant quality monitoring system is proposed. Biosensors in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages, including minimal invasiveness, making them suitable for the development of preimplant quality control systems.

scholarly journals Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials for Tissue Engineering

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5286
Author(s):  
Fernando Alvarado-Hidalgo ◽  
Karla Ramírez-Sánchez ◽  
Ricardo Starbird-Perez
Keyword(s):  
Tissue Engineering ◽  
Porous Materials ◽  
In Vitro Regeneration ◽  
Textural Properties ◽  
Host Cells ◽  
Future Research ◽  
Porous Scaffolds ◽  
3D Scaffold ◽  
Stimulation Of

Recently, tissue engineering and regenerative medicine studies have evaluated smart biomaterials as implantable scaffolds and their interaction with cells for biomedical applications. Porous materials have been used in tissue engineering as synthetic extracellular matrices, promoting the attachment and migration of host cells to induce the in vitro regeneration of different tissues. Biomimetic 3D scaffold systems allow control over biophysical and biochemical cues, modulating the extracellular environment through mechanical, electrical, and biochemical stimulation of cells, driving their molecular reprogramming. In this review, first we outline the main advantages of using polysaccharides as raw materials for porous scaffolds, as well as the most common processing pathways to obtain the adequate textural properties, allowing the integration and attachment of cells. The second approach focuses on the tunable characteristics of the synthetic matrix, emphasizing the effect of their mechanical properties and the modification with conducting polymers in the cell response. The use and influence of polysaccharide-based porous materials as drug delivery systems for biochemical stimulation of cells is also described. Overall, engineered biomaterials are proposed as an effective strategy to improve in vitro tissue regeneration and future research directions of modified polysaccharide-based materials in the biomedical field are suggested.

scholarly journals Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Changyong Liu ◽  
Junda Tong ◽  
Jun Ma ◽  
Daming Wang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Low Temperature ◽  
Porous Materials ◽  
Porous Electrodes ◽  
Tissue Engineering Scaffolds ◽  
Material Extrusion ◽  
Low Temperature Deposition ◽  
Wide Range ◽  
Temperature Deposition

Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

Preparation of Porous HAW/ß-TCP Ceramics with In Situ Synthesis of HA Whiskers

2010 ◽  
Vol 434-435 ◽  
pp. 617-619
Author(s):  
Qing Feng Zan ◽  
Yao Cong Han ◽  
Li Min Dong ◽  
Chen Wang ◽  
Jie Mo Tian
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Porous Materials ◽  
Bone Tissue ◽  
Phase Content ◽  
Calcium Phosphate Ceramics ◽  
Ceramics Matrix

Adding whiskers to ceramic was a way that has been used to strengthen the ceramics matrix. For porous materials, strength of pore walls was an important factor for strength of the whole materials. Porous calcium phosphate ceramics were always used as scaffolds of bone tissue engineering because of their biocompatible and osteoconductibility. In this work, HA whiskers were born in the porous -TCP ceramic during in situ procedure. The HA whiskers with about 2m for length and 100nm for diameter were observed from SEM photographs of as-fabricated porous HA ceramics, and the phase content was determined by XRD.

scholarly journals Biological aspects of application of nanomaterials in tissue engineering

2016 ◽  
Vol 22 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Dejan Markovic ◽  
Ivana Karadzic ◽  
Vukoman Jokanovic ◽  
Ana Vukovic ◽  
Vesna Vucic
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Future Research ◽  
Functional Features ◽  
Biological Aspects ◽  
Porous Biomaterials ◽  
Cell Carriers ◽  
Migration Of Cells ◽  
Major Emphasis

Millions of patients worldwide need surgery to repair or replace tissue that has been damaged through trauma or disease. To solve the problem of lost tissue, a major emphasis of tissue engineering (TE) is on tissue regeneration. Stem cells and highly porous biomaterials used as cell carriers (scaffolds) have an essential role in the production of new tissue by TE. Cellular component is important for the generation and establishment of the extracellular matrix, while a scaffold is necessary to determine the shape of the newly formed tissue and facilitate migration of cells into the desired location, as well as their growth and differentiation. This review describes the types, characteristics and classification of stem cells. Furthermore, it includes functional features of cell carriers - biocompatibility, biodegradability and mechanical properties of biomaterials used in developing state-of-the-art scaffolds for TE applications, as well as suitability for different tissues. Moreover, it explains the importance of nanotechnology and defines the challenges and the purpose of future research in this rapidly advancing field.

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