Background:
The uncontrolled growth due to accumulation of genetic and epigenetic changes as a result of
loss or reduction in the normal function of Tumor Suppressor Genes (TSGs) and Pro-oncogenes is known as cancer. TSGs
control cell division and growth by repairing of DNA mistakes during replication and restrict the unwanted proliferation
of a cell or activities, those are the part of tumor production.
Objectives:
This study aims to propose a novel, accurate, user-friendly model to predict tumor suppressor proteins, which
would be freely available to experimental molecular biologists to assist them using in vitro and in vivo studies.
Methods:
The predictor model has used the input feature vector (IFV) calculated from the physicochemical properties of
proteins based on FCNN to compute the accuracy, sensitivity, specificity, and MCC. The proposed model was validated
against different exhaustive validation techniques i.e. self-consistency and cross-validation.
Results:
Using self-consistency, the accuracy is 99%, for cross-validation and independent testing has 99.80% and 100%
accuracy respectively. The overall accuracy of the proposed model is 99%, sensitivity value 98% and specificity 99% and
F1-score was 0.99.
Conclusion:
It concludes, the proposed model for prediction of the tumor suppressor proteins can predict the tumor
suppressor proteins efficiently, but it still has space for improvements in computational ways as the protein sequences
may rapidly increase, day by day.