Synthesis and Properties of Thermo- and pH-Responsive PVA/P(DEA-co-MAA) Intelligent Semi-IPN Hydrogels

2012 ◽  
Vol 466-467 ◽  
pp. 229-233
Author(s):  
Nai Yan Zhang ◽  
Jiang Yu ◽  
Shou Jun Cai
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Radical Copolymerization ◽  
Unique Property ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Ph Responsive ◽  
Free Radical Copolymerization

A series of temperature- and pH-responsive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-methacrylic acid) PVA/P(DEA-co-MAA) intelligent semi-IPN hydrogels were synthesized by free-radical copolymerization techniques and semi-interpenetrating polymer network techniques. The effects of the feed components, temperature and pH on the swelling behavior of the hydrogels were studied in detail. This unique property makes them very useful for biomedical applications such as on-off switches for modulated drug delivery and tissue engineering. With the increase of PVA content, the thermo- and pH-responsive of the semi-IPN hydrogel improved.

Slow-Release Behaviors of Poly(vinyl alcohol)/Poly(N, N-diethylacrylamide-co-methacrylic acid) Semi-IPN Materials

2013 ◽  
Vol 709 ◽  
pp. 135-138 ◽  
Author(s):  
Xiao Qi Li ◽  
Nai Yan Zhang ◽  
Yang Xue Li ◽  
Hong Jin Li
Keyword(s):  
Methacrylic Acid ◽  
Vinyl Alcohol ◽  
Polymer Network ◽  
Ammonium Persulfate ◽  
Radical Copolymerization ◽  
Polymer Materials ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Porous Network ◽  
Free Radical Copolymerization

A series of semi-interpenetrating polymer materials of poly (vinyl alcohol)/poly (N, N-diethylacrylamide-co-methacrylic acid)(PVA/PDM) were synthesized by free radical copolymerization techniques and semi-interpenetrating polymer network techniques at room temperature with ammonium persulfate and N,N,N',N'-tetramethylethylene diamide as initiators and N,N'-methylenebisacrylamide as a crosslinker. The interior morphology by scanning electron microscopy (SEM) revealed that PVA introduced PDM materials have interconnected porous network structures. The release behaviors of the model drug, aminophylline, are found dependent on material composition and environmental temperature, which suggests that these materials have potential application as intelligent release carriers.

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

Designing of Biodegradable Interpenetrating Polymer Network of Poly(vinyl alcohol-co-acrylic acid)/sodium chloride hydrogel : An Approach to Drug Delivery

1970 ◽  
Vol 1 (2) ◽  
pp. 144-151
Author(s):  
Debajyoti Ray ◽  
Prafulla Kumar Sahoo ◽  
Guru Prasad Mohanta
Keyword(s):  
Drug Delivery ◽  
Thermal Stability ◽  
Sodium Chloride ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Electron Microscopic ◽  
Swelling Properties ◽  
Scanning Electron Microscopic Study ◽  
Thermal Stability Of

Interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA), generated insitu, were prepared by without any added crosslinker, using benzoyl peroxide an initiator and sodium chloride (NaCl) as additive. The response of the hydrogels with and without NaCl was observed by studying their swelling behavior, biodegradability and thermal stability. Scanning electron microscopic study revealed that the pores of the prepared IPN were mostly open in presence of NaCl, thus making the hydrogel macroporous. (PVA-co-PAA)/NaCl was found to be more biodegradable than without NaCl. The IPN hydrogel showed comparatively higher swelling at intestinal pH than that of gastric medium and presence of NaCl in the IPN increases the swelling properties in both media. Thermal stability of IPN was affected by copolymerization, due to increasing porosity of the IPN. The prepared nontoxic, hydrophilic IPN hydrogel system holds good for further drug delivery studies in connection to its superswelling and biodegradablity.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

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