Relations between calcidiol serum levels and bone mineral density in postmenopausal women with low bone density

1994 ◽  
Vol 55 (4) ◽  
pp. 253-256 ◽  
Author(s):  
M. E. Martínez ◽  
M. T. del Campo ◽  
M. J. Sánchez-Cabezudo ◽  
J. A. Garcia ◽  
M. T. Sánchez Calvín ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Serum Levels ◽  
Mineral Density ◽  
Low Bone Density

The state of bone mineral density in the prolapse of the pelvic organs

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 173-176
Author(s):  
Il’nur I. Musin ◽  
Timur B. Minasov ◽  
Raisa A. Naftulovich ◽  
Elena M. Popova ◽  
Karina N. Mingareeva ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Roc Analysis ◽  
Genital Prolapse ◽  
Outpatient Basis ◽  
Mineral Density ◽  
Severe Osteoporosis ◽  
Experimental Group

Background. Plausible predictions of future mortality and disability are useful aids in making decisions about priorities for medical research. Recent advances in medicine have led to the fact that some countries, such as Japan, have the highest life expectancy in the world. Osteoporotic fractures make a significant contribution to the development of morbidity and mortality in the aging population. Despite an active study of the mechanisms of the development of pelvic organ prolapse and disorders of bone mineral density separately, the general background of these diseases has previously been little studied. Aim. To study bone density according to densitometry data in peri- and postmenopausal women. Materials and methods. To carry out this study, 2 groups of women were formed. The first (experimental) group included 76 women admitted for routine surgical treatment of genital prolapse, the second group (control) 68 women without clinical manifestations of pelvic floor descent, who underwent a medical examination by a gynecologist on an outpatient basis. Results. Analysis of extragenital diseases in women included in the study showed a high prevalence in the experimental group of hypertension (p=0.028), osteochondrosis (p=0.001), scoliosis (p=0.028), hemorrhoids (p=0.013). Also, women in this group more often noted stretch marks on the skin (p=0.002) and were more often operated on for other diseases (p=0.043), which indicates the association of genital prolapse with undifferentiated connective tissue dysplasia and hypertension. The diagnosed severe osteoporosis (according to 1 or more densitometry indicators, where the T-score is less than -2.5) had a direct correlation with the duration of menopause. For a detailed analysis of the factors influencing severe osteoporosis in peri- and postmenopausal women, logistic regression analysis and ROC analysis were performed. The independent variable was the presence of severe osteoporosis, and the dependent variables were: stage according to POP-Q, the presence of hypertension, the presence of diabetes mellitus in history. Conclusion. This study confirms the presence of a comorbidity decrease in bone density according to densitometry and the presence of hypertension (p=0.028) and genital prolapse. According to the ROC analysis, an increase in the stage of genital prolapse according to the POP-Q classification increases the risk of developing severe osteoporosis.

scholarly journals Tracking of Bone Mass and Density during Childhood and Adolescence

2010 ◽  
Vol 95 (4) ◽  
pp. 1690-1698 ◽  
Author(s):  
Heidi J. Kalkwarf ◽  
Vicente Gilsanz ◽  
Joan M. Lappe ◽  
Sharon Oberfield ◽  
John A. Shepherd ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Sexual Maturation ◽  
Childhood And Adolescence ◽  
Z Score ◽  
Mineral Density ◽  
Growth Status ◽  
Low Bone Density ◽  
Z Scores

Abstract Context: Whether a child with low bone mineral density (BMD) at one point in time will continue to have low BMD, despite continued growth and maturation, is important clinically. The stability of a characteristic during growth is referred to as “tracking.” Objective: We examined the degree of tracking in bone mineral content (BMC) and BMD during childhood and adolescence and investigated whether tracking varied according to age, sexual maturation, and changes in growth status. Design: We conducted a longitudinal study with measurements at baseline and annually for 3 yr. Setting: The Bone Mineral Density in Childhood Study was conducted at five clinical centers in the United States. Study Participants: A total of 1554 girls and boys, ages 6–16 yr at baseline, participated in the study. Main Outcome Measures: Whole body, spine, hip, and forearm BMC and BMD were measured by dual-energy x-ray absorptiometry, and age-, sex-, and race-specific Z-scores were calculated. Deviation from tracking was calculated as the Z-score at yr 3 minus baseline. Results: Correlations between Z-scores at baseline and yr 3 ranged from 0.76–0.88. Among children with a Z-score below −1.5 at baseline, 72–87% still had a Z-score below −1 after 3 yr. Age, sexual maturation, and deviations in growth status (P < 0.01) were associated with deviation from tracking; however, tracking was strongly evident even after adjusting for the effects of age, maturation, and growth. Conclusions: Bone density showed a high degree of tracking over 3 yr in children and adolescents. Healthy children with low bone density will likely continue to have low bone density unless effective interventions are instituted.

scholarly journals D-vitamin-anyagcsere és osteoporosis szisztémás sclerosisban

2017 ◽  
Vol 158 (32) ◽  
pp. 1252-1258 ◽  
Author(s):  
Szilvia Szamosi ◽  
Ágnes Horváth ◽  
Zoltán Szekanecz ◽  
Gabriella Szűcs
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Systemic Sclerosis ◽  
Bone Density ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Low Bone Density

Abstract: In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is prevalent in several autoimmune diseases, including systemic sclerosis. Hypovitaminosis has been found to be associated with low bone mineral density and higher prevalence of osteoporosis in this group of patients. Determinants of low bone density in SSc are poorly understood. Studies have shown the importance of both traditional osteoporotic as well as disease-specific factors (extent of skin involvement, presence of internal organ manifestation, malabsorption, systemic sclerosis subtype, serological profile, medication) in the development of low bone mineral density. The relationship between low bone density in systemic sclerosis patients and the above mentioned risk factors may be more complex and the real role of each factor is unclear. Yet very few studies reported clinically relevant low bone mass outcomes such as fracture risk assessment and fracture associated mortality in scleroderma. This review aims to synthesize data about the essential role of vitamin D in immune homeostasis as well as the prevalence of hypovitaminosis, low bone density, changes in bone turnover markers and presence of osteoporosis in scleroderma patients. Orv Hetil. 2017; 158(32): 1252–1258.

ANABOLIC THERAPY AND OPTIMAL TREATMENT SEQUENCES FOR PATIENTS WITH OSTEOPOROSIS AT HIGH RISK FOR FRACTURE

2020 ◽  
Vol 26 (7) ◽  
pp. 777-786 ◽  
Author(s):  
Felicia Cosman
Keyword(s):  
Bone Mineral Density ◽  
High Risk ◽  
Bone Density ◽  
Fracture Risk ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Anabolic Agents ◽  
Anabolic Therapy ◽  
Fracture Study

Objective: Provide an update regarding anabolic medications for osteoporosis, which are often considered to be the last resort for patients with osteoporosis, after multiple fractures have already occurred and other medications have already been administered. Methods: Literature review and discussion. Results: Recent pivotal trial data for anabolic agents and randomized trials comparing anabolic and antiresorptive medications suggest that three anabolic agents (teriparatide, abaloparatide, and romosozumab) reduce nonvertebral and vertebral fractures faster and to a greater extent than potent antiresorptive treatments. Furthermore, bone density accrual is maximized when patients are given anabolic agents first, followed by potent antiresorptive therapy. Since total hip bone density during or after osteoporosis treatment has emerged as an excellent surrogate for future fracture risk, attaining a greater hip bone mineral density is a treatment goal for high-risk osteoporosis patients. Conclusion: This review defines the highest-risk patients and summarizes the rationale for the evolving role of anabolic therapy in the management of postmenopausal women at high risk for fracture. Abbreviations: ACTIVE = Abaloparatide Comparator Trial in Vertebral Endpoints; ARCH = Active Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk; BMD = bone mineral density; FRAME = Fracture Study in Postmenopausal Women with Osteoporosis; FRAX = Fracture Risk Assessment Tool; PTH = parathyroid hormone; TBS = trabecular bone score

Vitamin E serum levels and bone mineral density in postmenopausal women

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S184-S185
Author(s):  
J.M. Mata Granados ◽  
R. Cuenca Acevedo ◽  
M.D. Luque de Castro ◽  
J.M. Quesada Gómez
Keyword(s):  
Bone Mineral Density ◽  
Vitamin E ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Serum Levels ◽  
Mineral Density

scholarly journals Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density

2019 ◽  
Vol 14 ◽  
pp. 117727191984382 ◽  
Author(s):  
Fawaz Y Azizieh ◽  
Diaa Shehab ◽  
Khaled Al Jarallah ◽  
Renu Gupta ◽  
Raj Raghupathy
Keyword(s):  
Oxidative Stress ◽  
Bone Mineral Density ◽  
Superoxide Dismutase ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Serum Levels ◽  
Oxidative Stress Markers ◽  
Mineral Density ◽  
Stress Markers ◽  
And Oxidative Stress

Introduction: Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial. The aim of this study was to measure circulatory levels of these parameters in postmenopausal women with normal or low BMD. Methods: The study population included 71 postmenopausal women, of whom 25 had normal BMD, 31 had osteopenia, and 15 had osteoporosis. Serum levels of RANKL, OPG, and 5 oxidative stress markers (catalase, peroxiredoxin 2 [PRX2], superoxide dismutase 1 [SOD1], superoxide dismutase 2 [SOD2], and thioredoxin [TRx1]) were measured using the Multiplex system. Results: As compared with subjects having normal BMD, subjects with low BMD had significantly lower median serum levels of OPG, catalase, SOD2, and PRX2 ( P = .004, .031, .044, and .041 respectively). Although levels of RANKL were not different between the 2 groups, the RANKL/OPG ratio was higher in women with low BMD ( P = .027). Conclusions: These data provide insights into the possible roles of OPG, RANKL, and oxidative stress in the pathogenesis of postmenopausal osteoporosis. However, the lack of association between these markers and BMD indicates that osteoporosis is complex and multivariate.

Sign in / Sign up

Export Citation Format

Share Document