Cellular mechanism of the dependence of cardiotonic action of digoxin on the degree of ischemic damage to the myocardium

1989 ◽  
Vol 23 (6) ◽  
pp. 451-454
Author(s):  
M. R. Mukumov ◽  
S. A. Isaeva ◽  
A. V. Lazarev ◽  
�. A. Kim ◽  
M. P. Danilenko ◽  
...  
Keyword(s):  
Cellular Mechanism ◽  
Ischemic Damage ◽  
Cardiotonic Action

Neonatal myocardium is more sensitive to perioperative ischemic damage than myocardium of elder children

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
J. Suc ◽  
A. Purbojo ◽  
A. Rüffer ◽  
A. Koch ◽  
K.P. Eberle ◽  
...  
Keyword(s):  
Ischemic Damage

The role of membrane ion transport proteins in cerebral ischemic damage

10.2741/2099 ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 762 ◽  
Author(s):  
Douglas, B. Kintner
Keyword(s):  
Ion Transport ◽  
Transport Proteins ◽  
Ischemic Damage ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage ◽  
Membrane Ion Transport

Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids

2014 ◽  
Vol 11 (3) ◽  
pp. 207-213 ◽  
Author(s):  
Shou-Bao WANG ◽  
Xiao-Bin PANG ◽  
Mei GAO ◽  
Lian-Hua FANG ◽  
Guan-Hua DU
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Epoxyeicosatrienoic Acids ◽  
Ischemic Damage ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage

scholarly journals Gynura procumbens Root Extract Ameliorates Ischemia-Induced Neuronal Damage in the Hippocampal CA1 Region by Reducing Neuroinflammation

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 181
Author(s):  
Woosuk Kim ◽  
Hyo Young Jung ◽  
Dae Young Yoo ◽  
Hyun Jung Kwon ◽  
Kyu Ri Hahn ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Neuronal Damage ◽  
Ischemia Reperfusion ◽  
Treated Group ◽  
Biological Properties ◽  
Root Extract ◽  
Ischemic Damage ◽  
Neuroprotective Effects ◽  
Hippocampal Ca1 ◽  
Vehicle Treated Group

Gynura procumbens has been used in Southeast Asia for the treatment of hypertension, hyperglycemia, and skin problems induced by ultraviolet irradiation. Although considerable studies have reported the biological properties of Gynura procumbens root extract (GPE-R), there are no studies on the effects of GPE-R in brain damages, for example following brain ischemia. In the present study, we screened the neuroprotective effects of GPE-R against ischemic damage and neuroinflammation in the hippocampus based on behavioral, morphological, and biological approaches. Gerbils received oral administration of GPE-R (30 and 300 mg/kg) every day for three weeks and 2 h after the last administration, ischemic surgery was done by occlusion of both common carotid arteries for 5 min. Administration of 300 mg/kg GPE-R significantly reduced ischemia-induced locomotor hyperactivity 1 day after ischemia. Significantly more NeuN-positive neurons were observed in the hippocampal CA1 regions of 300 mg/kg GPE-R-treated animals compared to those in the vehicle-treated group 4 days after ischemia. Administration of GPE-R significantly reduced levels of pro-inflammatory cytokines such as interleukin-1β, -6, and tumor necrosis factor-α 6 h after ischemia/reperfusion. In addition, activated microglia were significantly decreased in the 300 mg/kg GPE-R-treated group four days after ischemia/reperfusion compared to the vehicle-treated group. These results suggest that GPE-R may be one of the possible agents to protect neurons from ischemic damage by reducing inflammatory responses.

Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage

1998 ◽  
Vol 782 (1-2) ◽  
pp. 212-218 ◽  
Author(s):  
Magali Reyes ◽  
Ayesha Reyes ◽  
Thoralf Opitz ◽  
Michael A Kapin ◽  
Patric K. Stanton
Keyword(s):  
Pyramidal Neurons ◽  
Hippocampal Slices ◽  
Nmda Antagonist ◽  
Ischemic Damage

scholarly journals The 61st Annual Meeting of the Japan Endocrine Society Symposium Cellular Mechanism of Hormon Action

1988 ◽  
Vol 64 (12) ◽  
pp. 1238-1242
Author(s):  
Arlene R. HUGHES ◽  
Debra A. HORSTMAN ◽  
James W. PURNEY Jr.
Keyword(s):  
Annual Meeting ◽  
Cellular Mechanism ◽  
Endocrine Society ◽  
Society Symposium

scholarly journals DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

2019 ◽  
Vol 116 (50) ◽  
pp. 25322-25328 ◽  
Author(s):  
Yi Liu ◽  
Xiaopin Ma ◽  
Hisashi Fujioka ◽  
Jun Liu ◽  
Shengdi Chen ◽  
...  
Keyword(s):  
Autosomal Recessive ◽  
Cellular Mechanism ◽  
Loss Of Function ◽  
Wild Type ◽  
Calcium Efflux ◽  
And Function ◽  
The Brain ◽  
Early Onset Parkinson’S Disease

Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset Parkinson’s disease (PD), yet the underlying pathogenic mechanism remains elusive. Here we demonstrate that DJ-1 localized to the mitochondria-associated membrane (MAM) both in vitro and in vivo. In fact, DJ-1 physically interacts with and is an essential component of the IP3R3-Grp75-VDAC1 complexes at MAM. Loss of DJ-1 disrupted the IP3R3-Grp75-VDAC1 complex and led to reduced endoplasmic reticulum (ER)-mitochondria association and disturbed function of MAM and mitochondria in vitro. These deficits could be rescued by wild-type DJ-1 but not by the familial PD-associated L166P mutant which had demonstrated reduced interaction with IP3R3-Grp75. Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro. Importantly, similar deficits in IP3R3-Grp75-VDAC1 complexes and MAM were found in the brain of DJ-1 knockout mice in vivo. The DJ-1 level was reduced in the substantia nigra of sporadic PD patients, which was associated with reduced IP3R3-DJ-1 interaction and ER-mitochondria association. Together, these findings offer insights into the cellular mechanism in the involvement of DJ-1 in the regulation of the integrity and calcium cross-talk between ER and mitochondria and suggests that impaired ER-mitochondria association could contribute to the pathogenesis of PD.

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