Physical linkage of genes encoding the lymphocyte adhesion molecules CD2 and its ligand LFA-3

1989 ◽  
Vol 30 (2) ◽  
pp. 123-125 ◽  
Author(s):  
Stephen F. Kingsmore ◽  
Mark L. Watson ◽  
Walton S. Moseley ◽  
Michael F. Seldin
Keyword(s):  
Adhesion Molecules ◽  
Lymphocyte Adhesion ◽  
Physical Linkage ◽  
Genes Encoding ◽  
Linkage Of Genes

scholarly journals Gene variants of adhesion molecules act as modifiers of disease severity in MS

2017 ◽  
Vol 4 (4) ◽  
pp. e350 ◽  
Author(s):  
Efthimios Dardiotis ◽  
Elena Panayiotou ◽  
Antonios Provatas ◽  
Kyproula Christodoulou ◽  
Andreas Hadjisavvas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Adhesion Molecules ◽  
Disease Severity ◽  
Disease Onset ◽  
Potential Effect ◽  
Nucleotide Polymorphisms ◽  
Permutation Testing ◽  
Lymphocyte Adhesion ◽  
Genes Encoding ◽  
Dose Dependent

Objective:To assess the potential effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the clinical phenotype of multiple sclerosis (MS).Methods:A total of 389 Greek MS cases and 336 controls were recruited in 3 MS centers from Cyprus and Greece. We genotyped 147 tagging single nucleotide polymorphisms (SNPs) in 9 genes encoding for P-selectin (SELP), integrins (ITGA4, ITGB1, and ITGB7), adhesion molecules (ICAM1, VCAM1, and MADCAM1), fibronectin 1 (FN1), and osteopontin (SPP1) involved in lymphocyte adhesion and trafficking into the CNS. Clinical end points of the study were age at MS onset and MS severity as measured by the Multiple Sclerosis Severity Score. Permutation testing was applied to all analyses.Results:SNPs rs6721763 of the ITGA4 and rs6532040 of the SPP1 were found to significantly influence disease severity (permutation p values: 3.00e-06 and 0.009884, respectively). SNP rs1250249 of the FN1 had a dose-dependent effect on age at disease onset (permutation p value: 0.0002).Conclusions:This study provides evidence implicating variants encoding adhesion molecules, responsible for lymphocyte adhesion and trafficking within the CNS, as modifiers of MS disease severity. These genetic biomarkers, which can be available at the time of diagnosis, may be used to assess the biological aggressiveness of the disease and thus guide decisions on treatment.

scholarly journals Gene variants of adhesion molecules predispose to MS: A case-control study

2019 ◽  
Vol 5 (1) ◽  
pp. e304 ◽  
Author(s):  
Efthimios Dardiotis ◽  
Elena Panayiotou ◽  
Vasileios Siokas ◽  
Athina-Maria Aloizou ◽  
Kyproula Christodoulou ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Case Control Study ◽  
Preliminary Evidence ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Lymphocyte Adhesion ◽  
Mcdonald Criteria ◽  
Genes Encoding ◽  
Permutation Analysis ◽  
Control Study

ObjectiveTo examine the effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the development of MS.MethodsA total of 389 Greek MS cases and 336 controls were recruited by 3 MS centers in Cyprus and Greece. In total, 147 tagging single nucleotide polymorphisms across 9 genes encoding for P-selectin (SELP), integrins (ITGA4, ITGB1, and ITGB7), adhesion molecules (ICAM1, VCAM1, and MADCAM1), fibronectin 1 (FN1), and osteopontin (SPP1) were genotyped. The clinical end point of the study was diagnosis of MS according to the 2005 revised McDonald criteria. Permutation analysis was used for adjusting for multiple comparisons.ResultsOverall, 21 variants across SELP, ITGA4, ITGB1, ICAM1, VCAM1, MADCAM1, FN1, and SSP1 genes were each associated with MS (pperm < 0.05). The most significant were rs3917779 and rs2076074 (SELP), rs6721763 (ITGA4), and rs1250258 (FN1), all with a permutation p value of less than 1e-004.ConclusionsThe current study provides preliminary evidence that variants across genes encoding adhesion molecules, responsible for lymphocyte adhesion and trafficking within the CNS, are implicated in the risk of developing MS.

scholarly journals The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 958-961
Author(s):  
YC Yang ◽  
S Kovacic ◽  
R Kriz ◽  
S Wolf ◽  
SC Clark ◽  
...  
Keyword(s):  
Sequence Similarity ◽  
Chromosome 5 ◽  
Ancestral Gene ◽  
Gm Csf ◽  
Human Genes ◽  
Physical Linkage ◽  
Genes Encoding ◽  
Macrophage Colony ◽  
Linkage Of Genes ◽  
Biologic Function

As demonstrated by long-range mapping of restriction endonuclease recognition sequences and genomic cloning, we found that the human genes encoding interleukin 3 (IL 3) and granulocyte/macrophage colony- stimulating factor (GM-CSF) are tandemly arrayed on the long arm of chromosome 5, separated by 9 kilobases (kb) of DNA. This close physical linkage of genes with similar structure and biologic function suggests that these cytokines may have evolved from a common ancestral gene. This linkage in evolution of two relatively divergent genes further implies that some of the other lymphokine and cytokine genes that appear to share as much or more sequence similarity than do IL 3 and GM- CSF may be distantly related members of a cytokine gene family.

scholarly journals The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 958-961 ◽  
Author(s):  
YC Yang ◽  
S Kovacic ◽  
R Kriz ◽  
S Wolf ◽  
SC Clark ◽  
...  
Keyword(s):  
Sequence Similarity ◽  
Chromosome 5 ◽  
Ancestral Gene ◽  
Gm Csf ◽  
Human Genes ◽  
Physical Linkage ◽  
Genes Encoding ◽  
Macrophage Colony ◽  
Linkage Of Genes ◽  
Biologic Function

Abstract As demonstrated by long-range mapping of restriction endonuclease recognition sequences and genomic cloning, we found that the human genes encoding interleukin 3 (IL 3) and granulocyte/macrophage colony- stimulating factor (GM-CSF) are tandemly arrayed on the long arm of chromosome 5, separated by 9 kilobases (kb) of DNA. This close physical linkage of genes with similar structure and biologic function suggests that these cytokines may have evolved from a common ancestral gene. This linkage in evolution of two relatively divergent genes further implies that some of the other lymphokine and cytokine genes that appear to share as much or more sequence similarity than do IL 3 and GM- CSF may be distantly related members of a cytokine gene family.

Close physical linkage of the genes encoding the pNR-2/pS2 protein and human spasmolytic protein (hSP)

1997 ◽  
Vol 99 (3) ◽  
pp. 303-307 ◽  
Author(s):  
F. E. B. May ◽  
Bruce R. Westley
Keyword(s):  
Physical Linkage ◽  
Genes Encoding ◽  
Ps2 Protein

scholarly journals Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

1988 ◽  
Vol 167 (4) ◽  
pp. 1271-1280 ◽  
Author(s):  
M C Carroll ◽  
E M Alicot ◽  
P J Katzman ◽  
L B Klickstein ◽  
J A Smith ◽  
...  
Keyword(s):  
Gel Electrophoresis ◽  
Southern Blotting ◽  
Chromosome 1 ◽  
Complement Receptors ◽  
Coding Sequences ◽  
Physical Linkage ◽  
Genes Encoding ◽  
Gradient Gel Electrophoresis ◽  
Human Chromosome 1

The organization and physical linkage of four members of a major complement locus, the RCA locus, have been determined using the technique of pulsed field gradient gel electrophoresis in conjunction with Southern blotting. The genes encoding CR1, CR2, DAF, and C4bp were aligned in that order within a region of 750 kb. In addition, the 5' to 3' orientation of the CR1 gene (5' proximal to CR2) was determined using 5'- and 3'-specific DNA probes. The proximity of these genes may be related to structural and functional homologies of the protein products. Overall, a restriction map including 1,500 kb of DNA was prepared, and this map will be important for positioning of additional coding sequences within this region on the long arm of chromosome 1.

scholarly journals Linkage of genes encoding enolase (eno) and CTP synthase (pyrG) in the β-subdivision proteobacteriumNitrosomonas europaea

1998 ◽  
Vol 165 (1) ◽  
pp. 153-157 ◽  
Author(s):  
Timothy J Mahony ◽  
David J Miller
Keyword(s):  
Ctp Synthase ◽  
Genes Encoding ◽  
Linkage Of Genes
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