Mechanism of interaction in the rheological system composed of a mechanized hydraulic face support and the surrounding rocks

1970 ◽  
Vol 6 (3) ◽  
pp. 276-280
Author(s):  
N. I. Yakovlev
RSC Advances ◽  
2020 ◽  
Vol 10 (35) ◽  
pp. 20862-20871
Author(s):  
Guoyan Ren ◽  
He Sun ◽  
Gen Li ◽  
Jinling Fan ◽  
Lin Du ◽  
...  

The mechanism of interaction between AE and trypsin was studied firstly. The biological activity of both decreased after the interaction. These results provide a basis for the development and utilization of AE.


2019 ◽  
Vol 968 ◽  
pp. 96-106
Author(s):  
Oleksandr Pshinko ◽  
Olena Hromova ◽  
Dmytro Rudenko

Study of rheological properties of concrete mixtures based on modified cement systems in order to determine process parameters. Methodology. To study structural-mechanical properties of modified concrete mixtures of different consistency at their horizontal vibrating displacement an oscillatory viscometer was designed. Results. The optimization of the process of vibration displacement of concrete mixtures with the specification of parameters of vibration impacts taking into account structural-mechanical properties of the mixture is performed. It has been established that the viscosity of the modified cement system of the concrete mixture is a variable quantity, which depends on the parameters of the vibration impacts. Scientific novelty. The mechanism of interaction of the modified concrete mixture with the form and the table vibrator during its vibration compaction is determined. On the basis of this, a model of concrete laying process control is proposed, that allows to predict the ability to form a dense concrete structure. Practical significance. Disclosed physical nature of the process of vibrating displacement of modified concrete mixtures using the principles of physical-chemical mechanics of concrete allows reasonably choose the best options for vibration impacts.


2021 ◽  
Vol 22 (14) ◽  
pp. 7390
Author(s):  
Nicole Wesch ◽  
Frank Löhr ◽  
Natalia Rogova ◽  
Volker Dötsch ◽  
Vladimir V. Rogov

Ubiquitin fold modifier 1 (UFM1) is a member of the ubiquitin-like protein family. UFM1 undergoes a cascade of enzymatic reactions including activation by UBA5 (E1), transfer to UFC1 (E2) and selective conjugation to a number of target proteins via UFL1 (E3) enzymes. Despite the importance of ufmylation in a variety of cellular processes and its role in the pathogenicity of many human diseases, the molecular mechanisms of the ufmylation cascade remains unclear. In this study we focused on the biophysical and biochemical characterization of the interaction between UBA5 and UFC1. We explored the hypothesis that the unstructured C-terminal region of UBA5 serves as a regulatory region, controlling cellular localization of the elements of the ufmylation cascade and effective interaction between them. We found that the last 20 residues in UBA5 are pivotal for binding to UFC1 and can accelerate the transfer of UFM1 to UFC1. We solved the structure of a complex of UFC1 and a peptide spanning the last 20 residues of UBA5 by NMR spectroscopy. This structure in combination with additional NMR titration and isothermal titration calorimetry experiments revealed the mechanism of interaction and confirmed the importance of the C-terminal unstructured region in UBA5 for the ufmylation cascade.


Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 107
Author(s):  
Agnieszka Piegat ◽  
Anna Żywicka ◽  
Agata Niemczyk ◽  
Agata Goszczyńska

The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid (CH_LA) was tested by disc and well diffusion, agar impregnation and microdilution methods against Staphylococcus aureus, Escherichia coli and Helicobacter pylori strains. Hydrophobically modified chitosan (HMC) was expected to exhibit enhanced antibacterial activity and specific mucin interactions. Although diffusion tests have not indicated the antibacterial potential of chitosan (CH) or CH_LA, the results of the microdilution method demonstrated that tested polymers significantly reduced the amount of living bacteria cells in different concentrations depending on the microorganism. Additionally, CH_LA was characterized by enhanced antibacterial activity compared to CH, which may suggest a different mechanism of interaction with S. aureus and H. pylori. Furthermore, the UV-VIS analysis revealed that the amphiphilic character of derivative led to strong CH_LA–mucin interactions. The study proved the high potential of CH_LA in antibacterial applications, especially for the gastrointestinal tract.


1999 ◽  
Vol 72 (8) ◽  
pp. 1927-1933
Author(s):  
Adam Košturiak ◽  
Ladislav Valko ◽  
Jirí Polavka ◽  
Milan Brutovsky ◽  
Harry Morris

1986 ◽  
Vol 261 (22) ◽  
pp. 10375-10379 ◽  
Author(s):  
T Mimori ◽  
J A Hardin

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Natalia Tarasova ◽  
Efrem Krivoborodov ◽  
Alexey Zanin ◽  
Yaroslav Mezhuev

AbstractThe opening of the S8 ring with the formation of linear sulfur oligomers in the presence of tri-n-butylmethylphosphonium dimethylphosphate is shown. The reaction products are separated and characterized with 1H, 13C, 31P, 17O NMR spectroscopy, HD-MS, MALDI spectroscopy and XRD. It is shown that dimethylphosphate-anion is active in the reaction, and the addition of sulfur atoms occurs via the oxygen atom of dimethylphosphate-anion. It is found that a mixture of products is formed, which differ in the number of sulfur atoms in the chain. The assumptions were made about the mechanism of interaction of sulfur with tri-n-butylmethylphosphonium dimethylphosphate.


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