Protective effect of ascorbic acid on bleaching activity of N-methyl-N′-nitro-N-nitrosoguanidine and furazolidone

1993 ◽  
Vol 38 (6) ◽  
pp. 501-504 ◽  
Author(s):  
P. Foltínová ◽  
J. Grones
Keyword(s):  
Ascorbic Acid ◽  
Protective Effect ◽  
Bleaching Activity

Protective effect of combined systemic ascorbic acid (vitamin C) and d-a-tocopherol (vitamin E) against sunburn in patients with malignant melanoma (MM)

1997 ◽  
Vol 7 (Supplement 1) ◽  
pp. S77
Author(s):  
M Placzek ◽  
B Eberlein-Konig ◽  
B Przybilla
Keyword(s):  
Ascorbic Acid ◽  
Vitamin E ◽  
Malignant Melanoma ◽  
Vitamin C ◽  
Protective Effect

scholarly journals Morphological changes in parenchymal organs of laboratory animals in acute effect of carbon tetrachloride

2020 ◽  
Vol 99 (9) ◽  
pp. 1001-1006
Author(s):  
Elvira F. Repina ◽  
Denis O. Karimov ◽  
Samat S. Baygildin ◽  
Gulnara V. Timasheva ◽  
Nadezhda Yu. Khusnutdinova ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Morphological Changes ◽  
Acute Exposure ◽  
Laboratory Animals ◽  
Antihypoxic Activity ◽  
Prophylactic Administration ◽  
Morphological Studies ◽  
High Doses

Introduction. Among noninfectious diseases, one of the leading places belongs to pathologies caused by the action of industrial toxicants. In this regard, the search for drugs for the prevention and treatment of various intoxications is one of the priority tasks of public health. Treatment of intoxication with drugs with antioxidant and antihypoxic activity is more effective. The aim of this study was to investigate morphological changes in parenchymal organs (liver, kidneys, and pancreas) under acute exposure to high doses of carbon tetrachloride and to evaluate the effectiveness of their correction with a new composition of oxymethyluracil with ascorbic acid. Material and methods. The composition of 5-hydroxy-6-methyluracil with ascorbic acid was first synthesized at the Ufa Institute of Chemistry, Ufa Federal Research Center, RAS. The preventive effect of the new drug was studied in comparison with “Heptor” on the carbon tetrachloride-induced liver injury model. Morphological studies of the liver, pancreas, and kidneys of laboratory animals were carried out. Results. Studies have shown the prophylactic administration of new composition of 5-hydroxy-6-methyluracil with ascorbic acid to have a protective effect on the structure of parenchymal organs in acute carbon tetrachloride intoxication, comparable to the drug “Heptor” (possibly superior). However, reparative properties were observed only in the drug “Heptor”. Conclusion. Comparative estimation of morphological changes in parenchymal organs under acute exposure to high doses of carbon tetrachloride indicates the protective effect of prophylactic administration of the composition of 5-hydroxy-6-methyluracil with ascorbic acid, comparable to the drug “Heptor” (possibly superior).

The protective effect of amino acids on the copper(II)-catalyzed autoxidation of ascorbic acid

2020 ◽  
Vol 16 (6) ◽  
Author(s):  
F. Imer ◽  
E. Aldemir ◽  
H. Kiliç ◽  
I. Sonmezoǧlu ◽  
R. Apak
Keyword(s):  
Amino Acids ◽  
Ascorbic Acid ◽  
Protective Effect

Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: An in vivo study

2020 ◽  
Vol 36 (6) ◽  
pp. 446-453
Author(s):  
Salma Awad Taghyan ◽  
Hend El Messiry ◽  
Medhat Ahmed El Zainy
Keyword(s):  
Silver Nanoparticles ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Protective Effect ◽  
Toxic Effect ◽  
Toxic Effects ◽  
Control Group ◽  
Albino Rats ◽  
Parotid Glands ◽  
Ductal Cells

This study aimed to evaluate the toxic effect of silver nanoparticles (AgNPs) on the parotid glands (PGs) of albino rats histologically and ultrastructurally and assess the possible protective effect of ascorbic acid as an antioxidant. Thirty male albino rats weighing between 150 mg and 200 mg were divided into three groups: the control group (C1) contained 10 rats that received 2 mg/kg (body weight (bw)) of aqueous nitrate buffer by intraperitoneal (IP) injection daily for 28 days; the AgNPs group contained 10 rats that received 2 mg/kg (bw) IP AgNPs daily for 28 days; and the AgNPs-vitamin C group contained 10 albino rats that received 2 mg/kg (bw) AgNPs IP daily for 28 days with oral administration of 100 mg/kg (bw) vitamin C in drinking water daily for 28 days. The PG acinar and ductal cells of the AgNPs group showed signs of toxicity and degeneration characterized as pleomorphic nuclei, binucleation, cytoplasmic vacuolations, and stagnated secretion in the ductal lumen. In addition to degenerated mitochondria, dilated rough endoplasmic reticulum and lysosomes were filled with AgNPs ( p < 0.001). The AgNPs-vitamin C group showed significantly less degenerative changes histologically and ultrastructurally compared to the AgNPs group ( p = 0.002). AgNPs produced significant toxic effects on the PG of albino rats, presumably through the generation of reactive oxygen species and toxic ion release, and administration of vitamin C was shown effective in decreasing these toxic effects.

Ultrastructural clues for the protective effect of ascorbic acid and N-acetylcysteine against oxidative damage on caerulein-induced pancreatitis

Pancreatology ◽  
2006 ◽  
Vol 6 (5) ◽  
pp. 477-485 ◽  
Author(s):  
Mukaddes Eşrefoğlu ◽  
Mehmet Gül ◽  
Burhan Ateş ◽  
Ismet Yilmaz
Keyword(s):  
Ascorbic Acid ◽  
Oxidative Damage ◽  
Protective Effect

Stabilization of papain from papaya peels / Estabilización de la papaína de la cáscara de papaya

1998 ◽  
Vol 4 (3) ◽  
pp. 179-187 ◽  
Author(s):  
N. Espin ◽  
M.N. Islam
Keyword(s):  
Ascorbic Acid ◽  
Enzyme Activity ◽  
Protective Effect ◽  
Total Concentration ◽  
Sodium Ascorbate ◽  
Sodium Metabisulfite ◽  
Appreciable Effect ◽  
Original Activity ◽  
Before And After ◽  
Erythorbic Acid

Crude papain in papaya peels was stabilized before drying by the addition of various chemicals (ascorbic acid, sodium ascorbate, erythorbic acid, sodium erythorbate, sodium metabisulfite, sodium tetrathionate, 4-hexylresorcinol, t-butyl hydroquinone [TBHQ], rutin, α-tocopherol, trehalose, and sucrose). Chemicals were added to the ground papaya peels at 0, 0.12, 0.25, 0.5, 0.75, 1, 1.25, and 1.5% (w /w). Drying temperatures were 40, 55 and 60 °C. Enzyme activity was measured before and after drying by the casein digestion method. Percentage of enzyme activity retained (% EAR) was calculated by assigning a value of 100% EAR to fresh peels. Possible synergism between chemicals was also studied for a 1:1 ratio chemical/chemical at 1% total concentration. The highest % EAR was obtained at 55 °C for all chemicals except for sucrose and trehalose which showed their best effect at 40 °C. TBHQ rutin, α-tocopherol and 4-hexylresorcinol showed a destabilizing effect. Maximum protective effect occurred at 1% concentration. At this concentration sodium tetrathionate showed the best protective effect (90% EAR) followed by sodium metabisulfite (85% EAR), while both sodium ascorbate and sodium erythorbate retained 75% of the original activity. Ascorbic acid and erythorbic acid were 10% less effective than their corresponding sodium salts, possibly due to lower pH. Trehalose showed only 57 % EAR while sucrose failed to produce any appreciable effect. No synergistic effect was shown by any combination of chemicals.

scholarly journals Caenorhabditis elegans to Model the Capacity of Ascorbic Acid to Reduce Acute Nitrite Toxicity under Different Feed Conditions: Multivariate Analytics on Behavioral Imaging

2021 ◽  
Vol 18 (4) ◽  
pp. 2068
Author(s):  
Samuel Verdu ◽  
Alberto J. Perez ◽  
Conrado Carrascosa ◽  
José M. Barat ◽  
Pau Talens ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Caenorhabditis Elegans ◽  
Protective Effect ◽  
Animal Health ◽  
Biological Systems ◽  
Meat Products ◽  
Processed Meat ◽  
Multivariate Statistical ◽  
C Elegans ◽  
Nitrite Toxicity

Nitrocompounds are present in the environment and human diet and form part of vegetables and processed meat products as additives. These compounds are related to negative impacts on human and animal health. The protective effect of ascorbic acid has been demonstrated by some biological systems as regards several nitrocompounds. This work focused on studying the possibility of modeling this effect on nitrite toxicity with the model Caenorhabditis elegans. The three factors studied in this work were ascorbic acid concentration, nitrite exposure concentration, and presence/absence of food. The protective effect was evaluated by scoring lethality and its impact on behavior by means of multivariate statistical methods and imaging analytics. The effects of nitrite and the influence of food availability were evidenced. Apart from increasing lethality, nitrite had disruption effects on movements. All the observed symptoms reduced when ascorbic acid was administered, and it diminished lethality in all cases. Ascorbic acid maintained nematodes’ postural capacities. The results suggest that nitrites’ nonspecific toxicity in C. elegans can be mitigated by ascorbic acid, as previously evidenced in other biological systems. Thus, our results reveal the ability of C. elegans to reproduce the known protective effect of ascorbic acid against nitrite.

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