Synergistic interaction and gelation in cationic guar gum-sodium alginate system

2004 ◽  
Vol 9 (3) ◽  
pp. 371-374 ◽  
Author(s):  
He Dong-bao ◽  
Li Li-hua ◽  
Li Qing ◽  
Yang Xiao-zhen
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
Synergistic Interaction

Advancement Of Changed Pulsincap Medicate Conveyance Arrangement Of Metronidazole For Tranquilize Focusing

2020 ◽  
Vol 2 (05) ◽  
pp. I-IV
Author(s):  
Roshni Jha ◽  
Anjali Minj
Keyword(s):  
Acetic Acid ◽  
Sodium Alginate ◽  
Guar Gum

A changed Pulsincap measurements type of metronidazole was created to target tranquilize discharge in the colon. Groups of hard gelatin cases were treated with formaldehyde keeping the tops in that capacity. Metronidazole pellets arranged by expulsion spheronization technique were consolidated into these particular container shells and stopped with polymers guar gum, hydroxypropylmethylcellulose 10K, carboxymethylcellulose sodium and sodium alginate independently at fixations 20 mg, 30 mg and 40 mg. The filled cases were totally covered with 5% cellulose acetic acid derivation phthalate to forestall variable gastric purging. All the definitions were tested to decide sedate substance and the capacity of the adjusted Pulsincap to give colon-explicit medication conveyance was surveyed by in vitro tranquilize discharge concentrates in cushion pH 1.2 for 2 h, pH 7.4 (reproduced intestinal liquid) for 3 h and pH 6.8 (animated colonic liquid) for 7 h. The outcomes showed that critical medication discharge happened simply after 5 h from the beginning of analysis.

Swelling behavior of barium ions-crosslinked bipolymeric sodium alginate–carboxymethyl guar gum blend beads

2006 ◽  
Vol 66 (6) ◽  
pp. 659-666 ◽  
Author(s):  
S.K. Bajpai ◽  
Shilpa Khare Saxena ◽  
Shubhra Sharma
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
Swelling Behavior ◽  
Barium Ions

scholarly journals Fabrication and Characterization of Anticancer Drug Loaded Double Walled Microspheres

2019 ◽  
Vol 9 (4-A) ◽  
pp. 79-85
Author(s):  
Elangovan Nagarajan ◽  
B Rama ◽  
M Swetha ◽  
G.S Sharma ◽  
L Jyothi Rani ◽  
...  
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Guar Gum ◽  
Diffusion Mechanism ◽  
Polymer Concentration ◽  
Methyl Cellulose ◽  
Entrapment Efficiency ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Breast Cancer Patients

In the present work, double walled microspheres of Tamoxifen (antiestrogenic drug) using Sodium alginate, Hydroxy propyl methyl cellulose (HPMC) K100,Guar gum, Xanthun gum were formulated to deliver Tamoxifen (TMX) through  oral route to treat breast cancer patients. Details regarding the preparation and evaluation of the formulations have been discussed in results. From the study following conclusions could be drawn. The results of this investigation indicate that Ion gelation method can be successfully employed to fabricate TMX microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Microspheres containing sodium alginate along with HPMC in 1:1 ratio had a least size range of 610µm. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size. The  invitro drug release decreased with increase in the polymer and copolymer concentration. Among all formulations F7 shows Maximum drug release in 12 th hr  when compared with other formulations. Analysis of drug release mechanism showed that the drug release from the formulations followed the Non fickian diffusion mechanism and follows zero order kinectics. Based on the results of evaluation tests formulation coded F7 was concluded as best formulation. Keywords : Tamoxifen, sodium alginate, HPMC, Microspheres, Diffusion, Copolymers,  Entrapment efficiency.

scholarly journals Oily in situ gels as an alternative floating platform for ketoconazole release

2020 ◽  
Vol 11 (2) ◽  
pp. 2638-2649
Author(s):  
Masar Basim Mohsin Mohamed ◽  
Iman Sabah Jaafar ◽  
Methaq Hamad Sabar ◽  
Marwa Hazem Jasim ◽  
Furqan M. Abdulelah ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Guar Gum ◽  
In Vitro Release ◽  
Medium Chain Triglyceride ◽  
Floating Platform ◽  
Release Study ◽  
Model Drug

Sodium alginate, calcium carbonate, and guar gum were mixed with oils such as olive oil (OO), sesame oil (SO), and medium chain triglyceride (MCT). The oily formulations were found to simplify the preparation of in situ floating gel. This was the aim of this study using ketoconazole (keto) as a model drug. The investigations for the floating property were established by In vitro gelling capacity study and In vitro floating study. Additionally, in vitro release study was applied to find the best formulations to delay the release of keto. Then, selected formulations were studied by FTIR and SEM. Lastly, in vivo gelation was performed to examine the gelation in the rat’s stomach. The results showed all formulations were floating after successful gelation as the least amount of sodium alginate to gel oils was 20% w/w. The gels in SO and OO were better than MCT in delaying keto release, and 30% w/w sodium alginate in SO was the best to delay the release of keto within 8 hours of the release study. Selected gels showed interactions between the keto molecules and the molecules of the gel contents by FTIR study, and SEM showed a difference in the internal structure of selected formulations. Lastly, the 30% w/w sodium alginate in SO proved to gel and remain in the rat's stomach in the following periods: 30 min, 1 hour, 2 hours, and after 8 hours. Oily suspension formulations showed floating properties in the stomach and slowed the release of keto and specifically 30% w/w of sodium alginate in SO.

Sorption, diffusion, and pervaporation separation of water-acetic acid mixtures through the blend membranes of sodium alginate and guar gum-grafted-polyacrylamide

2001 ◽  
Vol 83 (2) ◽  
pp. 259-272 ◽  
Author(s):  
Udaya S. Toti ◽  
Mahadevappa Y. Kariduraganavar ◽  
Kumaresh S. Soppimath ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Acetic Acid ◽  
Sodium Alginate ◽  
Guar Gum ◽  
Blend Membranes ◽  
Pervaporation Separation

scholarly journals Hydrocolloid Interferences in the Determination of Pectin by the Carbazole Method

2001 ◽  
Vol 84 (6) ◽  
pp. 1947-1950 ◽  
Author(s):  
Nikolaos B Kyriakidis ◽  
Evaggelia Psoma
Keyword(s):  
Sodium Alginate ◽  
Orange Juice ◽  
Guar Gum ◽  
Gum Arabic ◽  
Colorimetric Determination

Abstract In the colorimetric determination of pectin by the carbazole method, some of the interfering compounds have been identified but the possible interference of different hydrocolloids is not known. Several hydrocolloids are currently used in the preparation of imitation and adulterated orange juice for cloud stabilization. Hydrocolloids studied were gum arabic, carboxylmethyl cellulose, sodium alginate, carrageenan, guar gum, and xanthan. The effects of these hydrocolloids on the carbazole method for pectin determination was studied. Procedures are proposed for the correct use of the carbazole method for pectin determination in the presence of extraneous hydrocolloids.

Guar gum succinate-sodium alginate beads as a pH-sensitive carrier for colon-specific drug delivery

2016 ◽  
Vol 91 ◽  
pp. 45-50 ◽  
Author(s):  
D. Sathya Seeli ◽  
S. Dhivya ◽  
N. Selvamurugan ◽  
M. Prabaharan
Keyword(s):  
Drug Delivery ◽  
Sodium Alginate ◽  
Guar Gum ◽  
Alginate Beads ◽  
Ph Sensitive ◽  
Specific Drug ◽  
Colon Specific Drug Delivery

scholarly journals The Types of Polysaccharide Coatings and Their Mixtures as a Factor Affecting the Stability of Bioactive Compounds and Health-Promoting Properties Expressed as the Ability to Inhibit the α-Amylase and α-Glucosidase of Chokeberry Extracts in the Microencapsulation Process

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1994
Author(s):  
Kamil Haładyn ◽  
Karolina Tkacz ◽  
Aneta Wojdyło ◽  
Paulina Nowicka
Keyword(s):  
Antioxidant Activity ◽  
Sodium Alginate ◽  
Guar Gum ◽  
Polyphenolic Compounds ◽  
Alginate Solution ◽  
Polyphenolic Content ◽  
Negative Effect ◽  
Health Promoting ◽  
The Stability ◽  
Selection Of

This study aimed to evaluate the feasibility of microencapsulating chokeberry extract by extrusion, and assess the effects of the selected carrier substance on the contents of polyphenolic compounds, antioxidant activity, color of microspheres, and ability of microspheres to inhibit α-amylase and α-glucosidase, after 14 and 28 days of storage. The results showed that appropriate selection of the polysaccharide coating is of great importance for the proper course of the microencapsulation process, the polyphenolic content of chokeberry capsules, and their antioxidant and antidiabetic properties. The addition of guar gum to a sodium alginate solution significantly increased the stability of polyphenolic compounds in microspheres during storage, whereas the addition of chitosan had a significantly negative effect on the stability of polyphenols. The coating variant composed of sodium alginate and guar gum was also found to be the most favorable for the preservation of the antioxidant activity of the capsules. On the other hand, capsules composed of sodium alginate, guar gum, and chitosan showed the best antidiabetic properties, which is related to these tricomponent microspheres having the best α-glucosidase inhibition.

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