Perinatal transmission of hiv and diagnosis of hiv infection in infants: A review

1998 ◽  
Vol 167 (1) ◽  
pp. 28-32 ◽  
Author(s):  
C. B. Nourse ◽  
K. M. Butler
Keyword(s):  
Hiv Infection ◽  
Perinatal Transmission

“I was born with this?” Missed perinatal transmission of HIV infection in adolescents

2005 ◽  
Vol 36 (2) ◽  
pp. 128
Author(s):  
Kirsten B. Hawkins ◽  
Lawrence J. D’Angelo
Keyword(s):  
Hiv Infection ◽  
Perinatal Transmission

Perinatal Human Immunodeficiency Virus (HIV) Testing

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 791-794
Author(s):  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Vertical Transmission ◽  
Task Force ◽  
Perinatal Transmission ◽  
Pediatric Hiv ◽  
Number Of Children ◽  
Perinatal Hiv ◽  
Seroprevalence Data ◽  
Immunodeficiency Virus

PERINATAL INFECTIONS The primary route of human immunodeficiency virus (HIV) infection in infants is vertical transmission from HIV-infected mothers. This is of particular concern as the number of infected women and the number of children infected by perinatal transmission continue to increase rapidly. The number of perinatally acquired acquired immunodeficiency syndrome (AIDS) cases increased 17% in 1989 and 21% in 1990. Similarly, the number of heterosexually acquired AIDS cases increased 27% in 1989 and 40% in 1990. There is evidence that vertical transmission of HIV can occur in utero (congenital/transplacental, similar to rubella),1,2 in the postpartum period (breast-feeding), and perhaps in the intrapartum period (similar to hepatitis B).3 The relative frequency and efficiency of transmission during each of these periods remains uncertain. The best estimates of vertical transmission from an HIV-seropositive mother to the fetus range from 12.9% to 39%4-6 Although the risk of transmission appears to be increased in women who are symptomatic, this point is still unclear.5 Preliminary information suggests that the presence of high levels of high-affinity/avidity antibodies to specific epitopes of the gp 120 of HIV may be protective and may decrease or prevent vertical transmission,7-10 although others have not been able to confirm this finding.11 More detailed information on perinatal HIV infection,12 and infection control13 in pediatric HIV infection is available in previously published statements from the AAP Task Force on Pediatric AIDS. SEROPREVALENCE Anonymous seroprevalence data from newborn specimens are being collected in 44 states, Puerto Rico, and the District of Columbia. In some states, seroprevalence data are available by metropolitan area and/or by hospital of birth.

scholarly journals Prevention of Mother to Child Transmission (PMTCT) Program at Paropakar Maternity and Women’s Hospital: A Review

2014 ◽  
Vol 7 (2) ◽  
pp. 25-28
Author(s):  
M Shrestha ◽  
P Chaudhary ◽  
M Tumbhahangphe ◽  
J Poudel
Keyword(s):  
Hiv Infection ◽  
Pregnant Women ◽  
Migrant Worker ◽  
Mode Of Delivery ◽  
Perinatal Transmission ◽  
Feeding Practice ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Antiretroviral Prophylaxis ◽  
Mother To Child

Aims: Vertical transmission from mother to fetus is the main route of HIVinfection among children. This study is an effort to review utilization of prevention of mother to child transmission (PMTCT) services by pregnant women seeking care in Paropakar Maternity and Women’s Hospital (PMWH). Methods: Case records of 165 pregnant women with HIV positive status who delivered at Paropakar Maternity and Women’s Hospital, Kathmandu from April 2005 to Dec 2011 were reviewed. Demographic profile of these women and interventions to prevent mother to child transmission (MTCT) including antiretroviral prophylaxis (ARV), mode of delivery, infant feeding practice as well as HIV status of their children were recorded. Results: Hospital records showed 109262 antenatal attendees and 120823 deliveries including 165 HIV infected women who delivered in this facility. Prevalence of HIV infection among antenatal attendees was 0.11 % and 0.13% in hospital deliveries. Migrant worker spouse (44.2%) was the main source of infection in their wives. Eighty eight (55.7%) out of 150 eligible women received ARV drugs and 97% babies received antiretroviral prophylaxis . Spontaneous vaginal delivery occurred in 60% women and caesarean section performed in the rest. While 60.8% women opted for exclusive breast feeding, remaining 39.2% chose formula feeding. For prophylaxis of opportunistic infection, Cotrimoxazole was given to 70.3% children. The incidence of HIV infection in babies born to HIV infected mother was 5.1%. Conclusions: Integrating PMTCT services into existing maternal and child health system can significantly reduce perinatal transmission of HIV infection to children. DOI: http://www.dx.doi.org/10.3126/njog.v7i2.11138 Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 2 / Issue 14 / July-Dec, 2012 / 25-28

Syphilis and HIV Infection among Displaced Pregnant Women in Rural Mozambique

1994 ◽  
Vol 5 (2) ◽  
pp. 117-123 ◽  
Author(s):  
H A Cossa ◽  
S Gloyd ◽  
R G Vaz ◽  
E Folgosa ◽  
E Simbine ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Pregnant Women ◽  
Hiv Transmission ◽  
Perinatal Transmission ◽  
Anal Intercourse ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hiv Seroprevalence ◽  
High Prevalence ◽  
History Of

A cross-sectional study was conducted among displaced pregnant women in Mozambique to determine the prevalence and correlates of HIV infection and syphilis. Between September 1992 and February 1993, 1728 consecutive antenatal attendees of 14 rural clinics in Zambézia were interviewed, examined, and tested for HIV and syphilis antibodies. The seroprevalence of syphilis and HIV were 12.2% and 2.9%, respectively. Reported sexual abuse was frequent (8.4%) but sex for money was uncommon. A positive MHA-TP result was significantly associated with unmarried status, history of past STD, HIV infection, and current genital ulcers, vaginal discharge, or genital warts. Significant correlates of HIV seropositivity included anal intercourse, history of past STD, and syphilis. In summary, displaced pregnant women had a high prevalence of syphilis but a relatively low HIV seroprevalence suggesting recent introduction of HIV infection in this area or slow spread of the epidemic. A syphilils screening and treatment programme is warranted to prevent perinatal transmission and to reduce the incidence of chancres as a cofactor for HIV transmission.

HIV Infection, AIDS and Vaccines

2021 ◽  
Author(s):  
Khrystyna Hrynkevych ◽  
Heinz-J. Schmitt
Keyword(s):  
Immune System ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Opportunistic Infections ◽  
Sexual Transmission ◽  
Hiv Infections ◽  
Perinatal Transmission ◽  
Human Immune System ◽  
Acute Hiv Infection ◽  
Acquired Immunodeficiency

HIV (human immunodeficiency virus) is a retrovirus that infects CD4+ T cells of the human immune system. If the infection is not treated, these cells are destroyed, resulting in an acquired immunodeficiency, i.e., “AIDS” (acquired immunodeficiency syndrome). HIV owns a reverse transcriptase enzyme to convert its RNA into DNA, which is then integrated into the human genome – then undetectable by the immune system. Today, sexual transmission is the major route of HIV infection, while parenteral transmission (sharing needles among drug addicts; rarely blood transfusion) and perinatal transmission are also possible. Acute HIV infection is accompanied by infectious mononucleosis-like symptoms (fevers, rash, lymphadenopathy, sore throat, fatigue), followed by a chronic asymptomatic stage, with viral replication at low levels, followed years later by AIDS, characterized by a plethora of possible opportunistic infections and cancers that result from T-cell deficiency and finally in death within about 2–3 years. Antiretroviral treatment (ART) includes 6 main classes of medicines that affect different steps of viral activities. While no cure is possible, ART – and particularly “Highly active antiretroviral therapy” (HAART) – has made HIV infections a chronic disease and therapy also results in a reduction of transmission. A large variety of vaccine candidates have been assessed – including phase 3 studies – but for many reasons, none of them have been successful to date.

scholarly journals HIV disease among immigrants coming to Italy from outside of the European Union: a case-control study of epidemiological and clinical features

2001 ◽  
Vol 127 (3) ◽  
pp. 527-533 ◽  
Author(s):  
R. MANFREDI ◽  
L. CALZA ◽  
F. CHIODO
Keyword(s):  
European Union ◽  
Hiv Infection ◽  
Case Control Study ◽  
Perinatal Transmission ◽  
Case Control ◽  
Hiv Disease ◽  
The European Union ◽  
Cross Sectional ◽  
Control Study ◽  
The Eu

The epidemiological, clinical and therapeutic features of HIV disease diagnosed in 41 immigrants from outside of the European Union (EU), were compared with those of 123 Italian and EU patients, in a cross-sectional case-control study, with individuals matched according to age and gender. In total 4·15% of our patients came from outside of the EU (51·2% of them from subsaharan Africa), with a proportional predominance of females, and heterosexual and perinatal transmission of HIV disease (P < 0·0001 and P < 0·02, respectively). Compared with Italian and EU subjects, patients coming from abroad had a shorter duration of known HIV infection (P < 0·001), but only some subjects were aware of their HIV disease prior to immigration, or acquired HIV infection only after coming to Italy (14·6% and 12·2%, respectively). No cases of HIV-2 infection or co-infection were detected in either study group. Compared with controls, patients coming from outside of the EU had a comparable clinical and immunological status, and had similar antiretroviral therapy, which was administered earlier (P < 0·0001), and proved better tolerated (P < 0·04), than in Italian and EU subjects. The apparently more limited virological response (as expressed by a higher mean plasma viral load, and a lower rate of viral suppression at the last visit; P < 0·001 and P < 0·05, respectively), was probably a bias due to the shorter mean overall follow-up time (P < 0·0001), and the shorter mean duration of antiretroviral treatment (11·1±2·2 months of immigrants vs. 16·2±6·7 months of controls; P < 0·0001).

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