The neurotoxicity of glutamate, dopamine, iron and reactive oxygen species: Functional interrelationships in health and disease: A review — discussion

1999 ◽  
Vol 1 (1) ◽  
pp. 27-39 ◽  
Author(s):  
John Smythies
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Health And Disease

scholarly journals Reactive Oxygen Species: Beyond Their Reactive Behavior

2021 ◽  
Vol 46 (1) ◽  
pp. 77-87
Author(s):  
Arnaud Tauffenberger ◽  
Pierre J. Magistretti
Keyword(s):  
Reactive Oxygen Species ◽  
Second Messengers ◽  
Critical Role ◽  
Complex Function ◽  
Reactive Oxygen ◽  
High Reactivity ◽  
Oxygen Species ◽  
Health And Disease ◽  
Cellular Dysfunction ◽  
The Brain

AbstractCellular homeostasis plays a critical role in how an organism will develop and age. Disruption of this fragile equilibrium is often associated with health degradation and ultimately, death. Reactive oxygen species (ROS) have been closely associated with health decline and neurological disorders, such as Alzheimer’s disease or Parkinson’s disease. ROS were first identified as by-products of the cellular activity, mainly mitochondrial respiration, and their high reactivity is linked to a disruption of macromolecules such as proteins, lipids and DNA. More recent research suggests more complex function of ROS, reaching far beyond the cellular dysfunction. ROS are active actors in most of the signaling cascades involved in cell development, proliferation and survival, constituting important second messengers. In the brain, their impact on neurons and astrocytes has been associated with synaptic plasticity and neuron survival. This review provides an overview of ROS function in cell signaling in the context of aging and degeneration in the brain and guarding the fragile balance between health and disease.

scholarly journals Modulation of Reactive Oxygen Species in Health and Disease

Antioxidants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 513 ◽  
Author(s):  
Solomon Habtemariam
Keyword(s):  
Reactive Oxygen Species ◽  
Chemical Communication ◽  
Reactive Oxygen ◽  
Control Mechanisms ◽  
Oxygen Species ◽  
Health And Disease ◽  
Living Organisms

In diverse living organisms, signaling within the cell, chemical communication between cells or simply the fate of cells to survive or die is largely dependent on the intricate balance of control mechanisms related to reactive oxygen species (ROS)[...]

scholarly journals Reactive Oxygen Species in Health and Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Assim A. Alfadda ◽  
Reem M. Sallam
Keyword(s):  
Reactive Oxygen Species ◽  
Redox Regulation ◽  
Wide Spectrum ◽  
Biological Effects ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metabolic Products ◽  
Health And Disease ◽  
Regulatory Functions ◽  
Cellular Organelles

During the past decades, it became obvious that reactive oxygen species (ROS) exert a multitude of biological effects covering a wide spectrum that ranges from physiological regulatory functions to damaging alterations participating in the pathogenesis of increasing number of diseases. This review summarizes the key roles played by the ROS in both health and disease. ROS are metabolic products arising from various cells; two cellular organelles are intimately involved in their production and metabolism, namely, the endoplasmic reticulum and the mitochondria. Updates on research that tremendously aided in confirming the fundamental roles of both organelles in redox regulation will be discussed as well. Although not comprehensive, this review will provide brief perspective on some of the current research conducted in this area for better understanding of the ROS actions in various conditions of health and disease.

Reactive oxygen species in human health and disease

Nutrition ◽  
2001 ◽  
Vol 17 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Laura Castro ◽  
Bruce A Freeman
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Health And Disease
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