Locating the angular position of measured milling forces to determine dual-mechanism global cutting constants

One of the most common neurological disorders, which occurs among 1% of the population worldwide, is epilepsy. Therapeutic failure is common with epilepsy and nearly about 30% of patients fall in this category. Seizure suppression should not be the only goal while treating epilepsy but associated comorbidities, which can further worsen the condition, should also be considered. Treatment of such comorbidities such as depression, anxiety, cognition, attention deficit hyperactivity disorder and, various other disorders which co-exist with epilepsy or are caused due to epilepsy should also be treated. Novel targets or the existing targets are needed to be explored for the dual mechanism which can suppress both the disease and the comorbidity. New therapeutic targets such as IDO, nNOS, PAR1, NF-κb are being explored for their role in epilepsy and various comorbidities. This review explores recent therapeutic targets for the treatment of comorbidities associated with epilepsy.

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CALCULATION OF THE DEPENDENCE OF THE DISTANCE TO THE LOCATED OBJECT FROM THE CORNER POSITION OF THE VEHICLE LINE

Issues of radio electronics ◽

10.21778/2218-5453-2018-4-14-18 ◽

2018 ◽

pp. 14-18

Author(s):

V. V. Artyushenko ◽

A. V. Nikulin

Keyword(s):

Real Time ◽

Statistical Physics ◽

Angular Position ◽

Three Dimensional ◽

Line Of Sight ◽

Two Dimensional ◽

Radar Station ◽

Flight Mode ◽

Vector Algebra ◽

Analytical Expressions

To simulate echoes from the earth’s surface in the low flight mode, it is necessary to reproduce reliably the delayed reflected sounding signal of the radar in real time. For this, it is necessary to be able to calculate accurately and quickly the dependence of the distance to the object being measured from the angular position of the line of sight of the radar station. Obviously, the simplest expressions for calculating the range can be obtained for a segment or a plane. In the text of the article, analytical expressions for the calculation of range for two-dimensional and three-dimensional cases are obtained. Methods of statistical physics, vector algebra, and the theory of the radar of extended objects were used. Since the calculation of the dependence of the range of the object to the target from the angular position of the line of sight is carried out on the analytical expressions found in the paper, the result obtained is accurate, and due to the relative simplicity of the expressions obtained, the calculation does not require much time.

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Numerical Analysis of the Bond Strength between Two Methacrylic Polymers by Surface Modification

Materials ◽

10.3390/ma14143927 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3927

Author(s):

Joanna Taczała ◽

Katarzyna Rak ◽

Jacek Sawicki ◽

Michał Krasowski

Keyword(s):

Numerical Analysis ◽

Bond Strength ◽

Angular Position ◽

Fem Analysis ◽

Groove Depth ◽

Chemical Reagent ◽

Shear Process ◽

3D Geometry ◽

The Right ◽

Artificial Teeth

The creation of acrylic dentures involves many stages. One of them is to prepare the surfaces of artificial teeth for connection with the denture plates. The teeth could be rubbed with a chemical reagent, the surface could be developed, or retention hooks could be created. Preparation of the surface is used to improve the bond between the teeth and the plate. Choosing the right combination affects the length of denture use. This work focuses on a numerical analysis of grooving. The purpose of this article is to select the shape and size of the grooves that would most affect the quality of the bond strength. Two types of grooves in different dimensional configurations were analyzed. The variables were groove depth and width, and the distance between the grooves. Finally, 24 configurations were obtained. Models were analyzed in terms of their angular position to the loading force. Finite element method (FEM) analysis was performed on the 3D geometry created, which consisted of two polymer bodies under the shear process. The smallest values of the stresses and strains were characterized by a sample with parallel grooves with the grooving dimensions width 0.20 mm, thickness 0.10 mm, and distance between the grooves 5.00 mm, placed at an angle of 90°. The best dimensions from the parallel (III) and cross (#) grooves were compared experimentally. Specimens with grooving III were not damaged in the shear test. The research shows that the shape of the groove affects the distribution of stresses and strains. Combining the selected method with an adequately selected chemical reagent can significantly increase the strength of the connection.

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Scalable Output Linear Actuators, a Novel Design Concept Using Shape Memory Alloy Wires Driven by Fluid Temperature

Machines ◽

10.3390/machines9010014 ◽

2021 ◽

Vol 9 (1) ◽

pp. 14

Author(s):

Andres Osorio Salazar ◽

Yusuke Sugahara ◽

Daisuke Matsuura ◽

Yukio Takeda

Keyword(s):

Shape Memory Alloy ◽

Shape Memory ◽

Angular Position ◽

Scale Factor ◽

Design Concept ◽

Fluid Temperature ◽

Step Size ◽

Simple Method ◽

Output Characteristics ◽

Novel Design

In this paper, the concept of scalability for actuators is introduced and explored, which is the capability to freely change the output characteristics on demand: displacement and force for a linear actuator, angular position and torque for a rotational actuator. This change can either be used to obtain power improvement (with a constant scale factor), or to improve the usability of a robotic system according to variable conditions (with a variable scale factor). Some advantages of a scalable design include the ability to adapt to changing environments, variable resolution of step size, ability to produce designs that are adequate for restricted spaces or that require strict energy efficiency, and intrinsically safe systems. Current approaches for scalability in actuators have shortcomings: the method to achieve scalability is complex, so obtaining a variable scaling factor is challenging, or they cannot scale both output characteristics simultaneously. Shape Memory Alloy (SMA) wire-based actuators can overcome these limitations, because its two output characteristics, displacement and force, are physically independent from each other. In this paper we present a novel design concept for linear scalable actuators that overcome SMA design and scalability limitations by using a variable number of SMA wires mechanically in parallel, immersed in a liquid that transmits heat from a separate heat source (wet activation). In this concept, more wires increase the maximum attainable force, and longer wires increase the maximum displacement. Prototypes with different number of SMA wires were constructed and tested in isometric experiments to determine force vs. temperature behavior and time response. The heat-transmitting liquid was either static or flowing using pumps. Scalability was achieved with a simple method in all tested prototypes with a linear correlation of maximum force to number of SMA wires. Flowing heat transmission achieved higher actuation bandwidth.

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Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)37197-1 ◽

1994 ◽

Vol 269 (11) ◽

pp. 8324-8333

Author(s):

A. Weisz ◽

S. Oguchi ◽

L. Cicatiello ◽

H. Esumi

Keyword(s):

Gene Expression ◽

Transcriptional Regulation ◽

Interferon Gamma ◽

No Synthase ◽

Bacterial Lipopolysaccharide ◽

Dual Mechanism ◽

Post Transcriptional Regulation

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Influence of angular position on radar gun peak cricket ball speed measurements

Sports Biomechanics ◽

10.1080/14763141.2021.1887343 ◽

2021 ◽

pp. 1-14

Author(s):

Nathan D. W. Smith ◽

Dave J. Burke

Keyword(s):

Angular Position ◽

Ball Speed ◽

Cricket Ball

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Optimal Design of Novel Blade Profile for Savonius Wind Turbines

Energies ◽

10.3390/en14123484 ◽

2021 ◽

Vol 14 (12) ◽

pp. 3484

Author(s):

Tai-Lin Chang ◽

Shun-Feng Tsai ◽

Chun-Lung Chen

Keyword(s):

Wind Energy ◽

Drag Force ◽

Wind Turbines ◽

Rural Areas ◽

Large Scale ◽

Design Method ◽

Angular Position ◽

Vertical Axis ◽

Blade Profile ◽

Main Concept

Since the affirming of global warming, most wind energy projects have focused on the large-scale Horizontal Axis Wind Turbines (HAWTs). In recent years, the fast-growing wind energy sector and the demand for smarter grids have led to the use of Vertical Axis Wind Turbines (VAWTs) for decentralized energy generation systems, both in urban and remote rural areas. The goals of this study are to improve the Savonius-type VAWT’s efficiency and oscillation. The main concept is to redesign a Novel Blade profile using the Taguchi Robust Design Method and the ANSYS-Fluent simulation package. The convex contour of the blade faces against the wind, creating sufficient lift force and minimizing drag force; the concave contour faces up to the wind, improving or maintaining the drag force. The result is that the Novel Blade improves blade performance by 65% over the Savonius type at the best angular position. In addition, it decreases the oscillation and noise accordingly. This study achieved its two goals.

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