Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility

2021 ◽  
Author(s):  
Qiuyi Zhang ◽  
Yixuan Meng ◽  
Mulong Du ◽  
Shuwei Li ◽  
Junyi Xin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin E ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Common Genetic Variants ◽  
Related Pathway

scholarly journals Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41954 ◽  
Author(s):  
Janelle M. Hoskins ◽  
Pei-Shi Ong ◽  
Temitope O. Keku ◽  
Joseph A. Galanko ◽  
Christopher F. Martin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcome ◽  
Genetic Variants ◽  
Cancer Susceptibility

scholarly journals Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population‐based cohort study

2019 ◽  
Vol 145 (9) ◽  
pp. 2427-2432 ◽  
Author(s):  
Yazhou He ◽  
Evropi Theodoratou ◽  
Xue Li ◽  
Farhat V.N. Din ◽  
Peter Vaughan‐Shaw ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Large Population ◽  
Population Based ◽  
Colorectal Cancer Risk ◽  
Survival Outcomes ◽  
Common Genetic Variants

scholarly journals Common Genetic Variants in Wnt Signaling Pathway Genes as Potential Prognostic Biomarkers for Colorectal Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56196 ◽  
Author(s):  
Wen-Chien Ting ◽  
Lu-Min Chen ◽  
Jiunn-Bey Pao ◽  
Ying-Pi Yang ◽  
Bang-Jau You ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Genetic Variants ◽  
Wnt Signaling Pathway ◽  
Prognostic Biomarkers ◽  
Common Genetic Variants

Prostate cancer susceptibility genes: lessons learned and challenges posed.

2003 ◽  
pp. 225-259 ◽  
Author(s):  
J Simard ◽  
M Dumont ◽  
D Labuda ◽  
D Sinnett ◽  
C Meloche ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Screening Methods ◽  
Cancer Susceptibility Genes ◽  
Prostate Cancer Susceptibility ◽  
Common Genetic Variants

In most developed countries, prostate cancer is the most frequently diagnosed malignancy in men. The extent to which the marked racial/ethnic difference in its incidence rate is attributable to screening methods, environmental, hormonal and/or genetic factors remains unknown. A positive family history is among the strongest epidemiological risk factors for prostate cancer. It is now well recognized that the role of candidate genetic markers to this multifactorial malignancy is more difficult to identify than the identification of other cancer susceptibility genes. Indeed, despite the localization of several susceptibility loci, there has been limited success in identifying high-risk susceptibility genes analogous to BRCA1 or BRCA2 for breast and ovarian cancer. Nonetheless, three strong candidate susceptibility genes have been described, namely ELAC2 (chromosome 17p11/HPC2 region), 2'-5'-oligoadenylate-dependent ribonuclease L (RNASEL), a gene in the HPC1 region, and Macrophage Scavenger Receptor 1 (MSR1), a gene within a region of linkage on chromosome 8p. Additional studies using larger cohorts are needed to fully evaluate the role of these susceptibility genes in prostate cancer risk. It is also of interest to mention that a significant percentage of men with early-onset prostate cancer harbor germline mutation in the BRCA2 gene thus confirming its role as a high-risk prostate cancer susceptibility gene. Although initial segregation analyses supported the hypothesis that a number of rare highly penetrant loci contribute to the Mendelian inheritance of prostate cancer, current experimental evidence better supports the hypothesis that some of the familial risks may be due to inheritance of multiple moderate-risk genetic variants. In this regard, it is not surprising that analyses of genes encoding key proteins involved in androgen biosynthesis and action led to the observation of a significant association between a susceptibility to prostate cancer and common genetic variants in some of those genes.

scholarly journals Genetic Variants in the Regulatory T cell–Related Pathway and Colorectal Cancer Prognosis

2020 ◽  
Vol 29 (12) ◽  
pp. 2719-2728
Author(s):  
Sonja Neumeyer ◽  
Xinwei Hua ◽  
Petra Seibold ◽  
Lina Jansen ◽  
Axel Benner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Regulatory T Cell ◽  
Genetic Variants ◽  
Cancer Prognosis ◽  
Related Pathway
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