Clinical applications of computerized tomography 3-D reconstruction imaging for diagnosis and surgery in children with large liver tumors or tumors at the hepatic hilum

2007 ◽  
Vol 23 (11) ◽  
pp. 1045-1050 ◽  
Author(s):  
Qian Dong ◽  
Wenjian Xu ◽  
Buxian Jiang ◽  
Yun Lu ◽  
Xiwei Hao ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Liver Tumors ◽  
Clinical Applications ◽  
Hepatic Hilum

scholarly journals Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection.

1984 ◽  
Vol 2 (6) ◽  
pp. 637-642 ◽  
Author(s):  
R Mittal ◽  
C Kowal ◽  
T Starzl ◽  
D Van Thiel ◽  
K Bron ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Resection ◽  
Computerized Tomography ◽  
Liver Tumors ◽  
Imaging Techniques ◽  
Hepatic Metastases ◽  
Response To Treatment ◽  
Preoperative Ct ◽  
Malignant Liver ◽  
The Impact

Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection. Because of the impact of CT liver scan on major treatment decisions, it is important to assess its accuracy. Patients undergoing liver transplantation or resection provide a unique opportunity to test the accuracy of hepatic-imaging techniques by comparison of findings of preoperative CT scan with those at gross pathologic examination of resected specimens. Forty-one patients who had partial hepatic resection (34 patients) or liver transplantation (eight patients) for malignant (30 patients) or benign (11 patients) tumors were evaluable. Eight (47%) of 17 patients with primary malignant liver tumors, four (31%) of 13 patients with metastatic liver tumors, and two (20%) of 10 patients with benign liver tumors had tumor nodules in resected specimens that were not apparent on preoperative CT studies. These nodules varied in size from 0.1 to 1.6 cm. While 11 of 14 of these nodules were less than 1.0 cm, three of 14 were greater than 1.0 cm. These results suggest that conventional CT alone may be insufficient to accurately determine the presence or absence of liver metastases, extent of liver involvement, or response of hepatic metastases to treatment.

scholarly journals Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum

2021 ◽  
Author(s):  
L. Luerken ◽  
M. Doppler ◽  
S. M. Brunner ◽  
H. J. Schlitt ◽  
W. Uller
Keyword(s):  
Bile Duct ◽  
Cell Membrane ◽  
Open Surgery ◽  
Liver Tumors ◽  
Complete Response ◽  
Electric Pulses ◽  
Hepatic Hilum ◽  
Stereotactic Navigation

AbstractElectrochemotherapy (ECT) is a novel non-thermal ablative technique that combines chemotherapy and the application of electric pulses for reversible cell membrane electroporation. This method was recently performed in the treatment of deep-seated liver tumors during open surgery but experience about percutaneous ECT is rare and further developments like combination of percutaneous ECT with stereotactic navigated devices may be very promising. We report on a case of a 4.7 × 4.5 × 3.5 cm unresectable HCC at the hepatic hilum adjacent to the major vessels and the bile duct that was successfully treated using percutaneous ECT in combination with stereotactic navigation. Follow-up imaging 6 weeks and 6 months after ECT showed complete response.

scholarly journals Feasibility study of portable multi-energy computed tomography with photon-counting detector for preclinical and clinical applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chang-Lae Lee ◽  
Key Jo Hong ◽  
Namwoo Kim ◽  
Kwanhee Han ◽  
Dongkyu Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Spatial Resolution ◽  
Liver Tumors ◽  
Photon Counting ◽  
Clinical Applications ◽  
Tissue Segmentation ◽  
Post Contrast ◽  
Photon Counting Detector ◽  
Ct System

AbstractIn this study, preclinical experiments were performed with an in-house developed prototypal photon-counting detector computed tomography (PCD CT) system. The performance of the system was compared with the conventional energy-integrating detector (EID)-based CT, concerning the basic image quality biomarkers and the respective capacities for material separation. The pre- and the post-contrast axial images of a canine brain captured by the PCD CT and EID CT systems were found to be visually similar. Multi-energy images were acquired using the PCD CT system, and machine learning-based material decomposition was performed to segment the white and gray matters for the first time in soft tissue segmentation. Furthermore, to accommodate clinical applications that require high resolution acquisitions, a small, native, high-resolution (HR) detector was implemented on the PCD CT system, and its performance was evaluated based on animal experiments. The HR acquisition mode improved the spatial resolution and delineation of the fine structures in the canine’s nasal turbinates compared to the standard mode. Clinical applications that rely on high-spatial resolution expectedly will also benefit from this resolution-enhancing function. The results demonstrate the potential impact on the brain tissue segmentation, improved detection of the liver tumors, and capacity to reconstruct high-resolution images both preclinically and clinically.

Heat Transfer and Tissue Damage in Radiofrequency Ablation Therapy

2009 ◽  
Author(s):  
M. Erol Ulucakli
Keyword(s):  
Heat Transfer ◽  
Radiofrequency Ablation ◽  
Liver Tumors ◽  
Lesion Size ◽  
Clinical Applications ◽  
Temperature Changes ◽  
Ablation Therapy ◽  
Complicating Factors ◽  
Thermal And Electrical Properties ◽  
Radiofrequency Ablation Therapy

Heat transfer in radiofrequency ablation therapy of liver tumors is discussed. Temporal and spatial temperature changes around a single needle and multi-prong ablation probes in monopolar and bipolar configurations based on a two-dimensional finite elements method are presented. The temperature changes and related heat transfer in the tissue model help to visualize the shape and size of the ablated region. The visualization of the tissue temperatures and their progression could be useful in clinical applications of ablation therapy. Finite-element based numerical simulation, while providing useful visualizations of the temperature changes in and around the tumor, underestimates the lesion size. The perfusion in the tissue and the possible presence of large blood vessels in or near the ablated domain, and the temperature dependency of the thermal and electrical properties of the tissue are significant complicating factors in modeling and clinical applications.

Specimen Preparation for Clinical Applications of X-Ray Microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 328-329
Author(s):  
J.D. Shelburne ◽  
G.M. Roomans
Keyword(s):  
Carbon Coating ◽  
Clinical Applications ◽  
Point Of View ◽  
Practical Significance ◽  
Sweat Test ◽  
Specimen Preparation ◽  
Tissue Preparation ◽  
X Ray ◽  
Gallbladder Stones ◽  
Clinical Problems

Proper preparative procedures are a prerequisite for the validity of the results of x-ray microanalysis of biological tissue. Clinical applications of x-ray microanalysis are often concerned with diagnostic problems and the results may have profound practical significance for the patient. From this point of view it is especially important that specimen preparation for clinical applications is carried out correctly.Some clinical problems require very little tissue preparation. Hair, nails, and kidney and gallbladder stones may be examined and analyzed after carbon coating. High levels of zinc or copper in hair may be indicative of dermatological or systemic diseases. Nail clippings may be analyzed (as an alternative to the more conventional sweat test) to confirm a diagnosis of cystic fibrosis. X-ray microanalysis in combination with scanning electron microscopy has been shown to be the most reliable method for the identification of the components of kidney or gallbladder stones.A quantitatively very important clinical application of x-ray microanalysis is the identification and quantification of asbestos and other exogenous particles in lung.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

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