scholarly journals Is the prognosis the same for periprosthetic joint infections due to Staphylococcus aureus versus coagulase-negative staphylococci? A retrospective study of 101 patients with 2-year minimum follow-up

2016 ◽  
Vol 136 (10) ◽  
pp. 1357-1361 ◽  
Author(s):  
J. Murgier ◽  
J.-M. Laffosse ◽  
J. Cailliez ◽  
E. Cavaignac ◽  
P. Murgier ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Retrospective Study ◽  
Coagulase Negative Staphylococci ◽  
Joint Infections

scholarly journals Incidence and risk factors for surgical site infection following elective foot and ankle surgery: a retrospective study

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Jinghong Meng ◽  
Yanbin Zhu ◽  
Yansen Li ◽  
Tao Sun ◽  
Fengqi Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Retrospective Study ◽  
Surgical Site Infection ◽  
Elective Surgery ◽  
Site Infection ◽  
Foot And Ankle ◽  
Coagulase Negative Staphylococci ◽  
Methicillin Resistant ◽  
Associated Risk Factors

Abstract Background This study aimed to investigate the incidence of surgical site infection (SSI) in elective foot and ankle surgeries and identify the associated risk factors. Methods This was designed as a retrospective study, including patients who underwent elective surgery of foot and ankle between July 2015 and June 2018. Data on demographics, comorbidities, and perioperative parameters were collected from the medical records, the laboratory report, the operation report, and the outpatient follow-up registration database. SSI was defined in accordance with the Center for Disease Control criteria. Univariate and multivariate logistic regression analyses were used to identify the independent risk factors for SSI. Results A total of 1201 patients undergoing 1259 elective foot/ankle surgeries were included, of whom 26 (2.1%) had an SSI, representing an incidence rate of 1.3% for superficial SSI and 0.8% for deep SSI, respectively. The results for organism culture showed Pseudomonas aeruginosa in 7 cases, methicillin-resistant Staphylococcus aureus (MRSA) in 6, methicillin-susceptible Staphylococcus aureus (MSSA) in 5, methicillin-resistant coagulase-negative Staphylococci (MRCNS) in 2, Escherichia coli in 2, and Proteus mirabilis in 1 case. Five factors were identified to be independently associated with SSI, including prolonged preoperative stay (OR, 1.21; 95% CI, 1.09 to 1.30), allograft or bone substitute (OR, 3.76; 95% CI, 1.51 to 5.30), elevated FBG level (OR, 1.17; 95% CI, 1.04 to 1.26), lower ALB level (OR, 2.33; 95% CI, 1.19 to 3.05), and abnormal NEUT count (OR, 1.72; 95% CI, 1.27 to 2.12). Conclusions SSI following elective foot and ankle surgeries is low, but relatively high in forefoot surgeries, requiring particular attention in clinical practice. Although most not modifiable, these identified factors aid in risk assessment of SSI and accordingly stratifying patients and therefore should be kept in mind.

scholarly journals Microbiological pathogen analysis in native versus periprosthetic joint infections: a retrospective study

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Sebastian Linke ◽  
Alexander Thürmer ◽  
Kevin Bienger ◽  
Christian Kleber ◽  
Petri Bellova ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Joint Infection ◽  
Tertiary Care ◽  
University Hospital ◽  
Nominal Data ◽  
Coagulase Negative Staphylococci ◽  
Joint Infections ◽  
Distributed Parameters ◽  
Chi Squared ◽  
Culture Positive

Abstract Background The presence or absence of an implant has a major impact on the type of joint infection therapy. Thus, the aim of this study was the examination of potential differences in the spectrum of pathogens in patients with periprosthetic joint infections (PJI) as compared to patients with native joint infections (NJI). Methods In this retrospective study, we evaluated culture-positive synovial fluid samples of 192 consecutive patients obtained from January 2018 to January 2020 in a tertiary care university hospital. For metrically distributed parameters, Mann–Whitney U was used for comparison between groups. In case of nominal data, crosstabs and Chi-squared tests were implemented. Results Overall, 132 patients suffered from periprosthetic joint infections and 60 patients had infections of native joints. The most commonly isolated bacteria were coagulase-negative Staphylococci (CNS, 28%), followed by Staphylococcus aureus (S. aureus, 26.7%), and other bacteria, such as Streptococci (26.3%). We observed a significant dependence between the types of bacteria and the presence of a joint replacement (p < 0.05). Accordingly, detections of CNS occurred 2.5-fold more frequently in prosthetic as compared to native joint infections (33.9% vs. 13.4% p < 0.05). In contrast, S. aureus was observed 3.2-fold more often in NJIs as compared to PJIs (52.2% vs. 16.4%, p < 0.05). Conclusion The pathogen spectra of periprosthetic and native joint infections differ considerably. However, CNS and S. aureus are the predominant microorganisms in both, PJIs and NJIs, which may guide antimicrobial therapy until microbiologic specification of the causative pathogen.

Prosthetic Joint Infections due to Staphylococcus Aureus and Coagulase-Negative Staphylococci

2012 ◽  
Vol 35 (10) ◽  
pp. 884-892 ◽  
Author(s):  
Eduard Tornero ◽  
Ester García-Oltra ◽  
Sebastían García-Ramiro ◽  
Juan C. Martínez-Pastor ◽  
Jordi Bosch ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Coagulase Negative Staphylococci ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections

scholarly journals Species and antimicrobial susceptibility testing of coagulase-negative staphylococci in periprosthetic joint infections

2018 ◽  
Vol 146 (14) ◽  
pp. 1771-1776 ◽  
Author(s):  
J. Lourtet-Hascoët ◽  
M. P. Félicé ◽  
A. Bicart-See ◽  
A. Bouige ◽  
G. Giordano ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Antimicrobial Susceptibility Testing ◽  
Coagulase Negative Staphylococci ◽  
Resistant Species ◽  
Joint Infections ◽  
Multicentre Retrospective Study

AbstractThe objective was to evaluate the distribution of coagulase-negative staphylococci (CNS) involved in periprosthetic-joint infections (PJIs) and to describe their susceptibility profile to antibiotics. We conducted a multicentre retrospective study in France, including 215 CNS PJIs between 2011 and 2015. CNS PJIs involved knees in 54% of the cases, hips in 39%, other sites in 7%. The distribution of the 215 strains was:Staphylococcus epidermidis129 (60%),Staphylococcus capitis24 (11%),Staphylococcus lugdunensis21 (10%),Staphylococcus warneri8 (4%),Staphylococcus hominis7 (3%),Staphylococcus haemolyticus7 (3%). More than half of the strains (52.1%) were resistant to methicillin, 40.9% to ofloxacin, 20% to rifampicin. The species most resistant to antibiotics wereS.hominis,S. haemolyticus,S. epidermidis,with 69.7% of the strains resistant to methicillin and 30% simultaneously resistant to clindamycin, cotrimoxazole, ofloxacin and rifampicin. No strain was resistant to linezolid or daptomycin. In this study on CNS involved in PJIs, resistance to methicillin is greater than 50%.S. epidermidisis the most frequent and resistant species to antibiotics. Emerging species suchS. lugdunensis,S. capitisandStaphylococcus capraeexhibit profiles more sensitive to antibiotics. The antibiotics most often activein vitroare linezolid and daptomycin.

scholarly journals Intermittent negative blood cultures in Staphylococcus aureus bacteremia; A retrospective study of 1071 episodes

2019 ◽  
Author(s):  
James D Stewart ◽  
Maryza Graham ◽  
Despina Kotsanas ◽  
Ian Woolley ◽  
Tony M Korman
Keyword(s):  
Staphylococcus Aureus ◽  
Retrospective Study ◽  
Prognostic Factor ◽  
Blood Culture ◽  
Predictive Value ◽  
Critical Role ◽  
Blood Cultures ◽  
Staphylococcus Aureus Bacteremia ◽  
Microbiological Data

Abstract Background Recommended management of Staphylococcus aureus bacteremia (SAB) includes follow up blood culture sets (BCs) to determine the duration of bacteremia. Duration of bacteremia is an important prognostic factor in SAB and follow up BCs have a critical role in differentiation of uncomplicated and complicated SAB. However, intermittent negative BCs occur in SAB. Clinical guidelines for SAB management do not specify an approach to follow up BCs collection or define the number of negative BCs required to demonstrate resolution of bacteremia. This study assessed the frequency of intermittent negative BCs in SAB and used these finding to formulate a recommendation for collection of follow up BCs. Methods This retrospective study reviewed 1071 episodes of SAB. Clinical and microbiological data including the duration of bacteremia and the occurrence of intermittent negative BCs (those preceded and followed by positive cultures) were considered. Results Intermittent bacteremia occurred in 13% (140/1071) of episodes. A single negative BCs on days 1-3 had a predictive value of 87-93% for resolution of bacteremia although this was improved if all BCs collected within the same day were considered. Conclusions Intermittent negative BCs are common in SAB. Given this we would not recommend accepting a single negative BCs as demonstrating resolution of the bacteremia. This is particularly important if a patient is to be classified as having an uncomplicated SAB.

scholarly journals 251. Poor Outcomes in the Treatment of Coagulase-Negative Staphylococci Periprosthetic Joint Infections

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S233-S233
Author(s):  
Ayden Case ◽  
Lefko T Charalambous ◽  
Jessica Seidelman ◽  
Edward Hendershot ◽  
William Jiranek ◽  
...  
Keyword(s):  
Board Member ◽  
Treatment Success ◽  
Research Support ◽  
Coagulase Negative Staphylococci ◽  
Educational Support ◽  
Material Support ◽  
Joint Infections ◽  
Skin Flora ◽  
One Year

Abstract Background Coagulase-negative staphylococci (CoNS) are a common skin flora often considered lab contaminants, but these pathogens can also be the cause of periprosthetic joint infections (PJIs). The role of these organisms in PJIs is not well characterized, with little data relating to treatment outcomes. We sought to evaluate success at one year for patients undergoing treatment for a CoNS PJI. Methods This is a retrospective cohort study of adults at a tertiary academic center from 2009 to 2020 with CoNS PJI. An institutional database was queried to identify potential patients and manually reviewed by two infectious disease specialists to confirm inclusion. Variables included sex, follow-up time, procedure type, age, race, Elixhauser score, success at one year, failure organism, and revisions. Both univariate and descriptive statistics were used to assess findings. Results We identified 61 patients with a CoNS PJI. The cohort was 50.8% male, with 49 patients identifying as Caucasian (80.3%), and 10 as African American (16.4%). The median age was 65.0 years old, the median Elixhauser score was 3.0, and the average follow-up time was 24.4 months. Of the 61 patients in the cohort, 24 underwent successful treatment (39.3%) at one year, and 37 failed treatment (60.7%). Within the failure group, 19 experienced persistence of the same organism (51.4%), 11 were infected by another organism (29.7%), and 28 underwent a revision surgery secondary to failure (76.9%). When stratified by treatment procedure after initial PJI, 26 (41.7%) received debridement, antibiotics, and implant retention (DAIR) whereas 35 (58.3%) underwent resection. Treatment success was not significantly different between the two procedures (p=0.964). Summary of Treatment Success for CoNS PJI Conclusion These results indicate that the success rate of treatment for CoNS PJI is less than for other organisms, such as coagulase-positive staphylocci. These results provide a focus for future research and clinical management of PJIs resulting from CoNS. Disclosures William Jiranek, MD, Depuy Synthes (Other Financial or Material Support, Royalty/Licensing) Michael Bolognesi, MD, Heron Therapeutics, Inc. (Consultant)Total Joint Orthopedics, Inc. (Other Financial or Material Support, Royalty/Licensing)Zimmer Biomet Holdings, Inc. (Other Financial or Material Support, Royalty/Licensing) Thorsten Seyler, MD/PhD, Depuy Synthes (Other Financial or Material Support, Resident Educational Support)Extrel Therapeutics (Board Member, Shareholder)Heraeus Medical (Consultant)MiCare Path (Board Member, Shareholder)OREF (Grant/Research Support)Pattern health (Board Member)Restor3D (Other Financial or Material Support, Royalties)Smith+Nephew, Inc. (Grant/Research Support, Speaker’s Bureau)Stryker (Other Financial or Material Support, Resident Educational Support)Total Joint Orthopedics, Inc. (Consultant)Wolters Kluwer Health (Other Financial or Material Support, Royalties)Zimmer Biomet (Grant/Research Support)

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