Evaluation of the information given to patients undergoing total pharyngolaryngectomy and quality of life: a prospective multicentric study

Background:Objectives:Analyse the effect of secukinumab in terms of the patient´s own variables, specifically: fatigue, sleep, pain and quality of life in patients with psoriatic arthritis or spondyloarthritis.Methods:A multicentric longtitudinal observational prospective study was carried out at 6 months in patients who begin treatment with secukinumab. At the start and after 6 months the following data was collected on the outcome: pain through an visual analogue scale (VAS), fatigue using the FACIT-fatigue scale, sleeping problems using the insomnia severity index (ISI) and quality of life with the EuroQol-3L-5D and the PsAQoL.The sample can be described in terms of the distribution of the variables through measures of central tendency.It was analysed if the change after 6 months was statistically relevant using Student´s t-test for paired data in the case of FACIT, VAS, PsAQoL and ISI and chi-squared for the dimensions of the EQ-5D. The size of the effect of each of the measurements taken was calculated using Cohen’s D. the results are given grouped by disease and globally. The analysis was carried out using Stata v12 (College Station Tx, USA)Results:In table 1, the changes in the scales of normal distribution can be seen. Apart from general VAS, all the scales experience significant relevant changes. The PROs preferred by the patient with the best therapeutic response is the quality of sleep. The adjustment of the regression models does not produce changes in the results, apart from small adjustments to the condidence intervals (final column table 1). The subdomain in which the most significant change in the EQ-5D is produced is in that of pain and discomfort.Conclusion:After 6 months patients who begin treatment with secukinumab, present with improvements in all sizes of the effects of the treatment in the various studied scales. The improvement achieves global and generalised statistical significance after 6 months of study. The greatest effect is on sleep, quality of life and fatigue.The measurements of the outcomes reported by the patients are a clinical value added to our objective evaluations of the health and activity of the disease, and allow us, in a more integrated and comprehensive manner, to undertake a more exact and close evaluation of their state of health and wellbeing.Disclosure of Interests:JUAN JOSE LERMA: None declared, Antonio Gracia: None declared, Antonio Perez: None declared, Amalia Rueda: None declared, Clara Molina: None declared, M. Dolores Pastor: None declared, Isabel Balaguer Trull: None declared, Inmaculada Valiente: None declared, Cristina Campos Fernández: None declared, Javier Calvo: None declared, Loreto Carmona Grant/research support from: Novartis Farmaceutica, SA, Pfizer, S.L.U., Merck Sharp & Dohme España, S.A., Roche Farma, S.A, Sanofi Aventis, AbbVie Spain, S.L.U., and Laboratorios Gebro Pharma, SA (All trhough institution)

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Factors affecting the quality of life of haemodialysis patients from Romania: a multicentric study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfn506 ◽

2008 ◽

Vol 24 (2) ◽

pp. 626-629 ◽

Cited By ~ 29

Author(s):

A. Seica ◽

L. Segall ◽

C. Verzan ◽

N. Vaduva ◽

M. Madincea ◽

...

Keyword(s):

Quality Of Life ◽

Multicentric Study ◽

Factors Affecting

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Effect of Cutaneous Leishmaniasis on Quality of Life of Patients, a Multicentric Study in Tertiary Care Hospitals in Pakistan Using DLQI

International Journal of Clinical and Experimental Medical Sciences ◽

10.11648/j.ijcems.20210704.16 ◽

2021 ◽

Vol 7 (4) ◽

pp. 103

Author(s):

Najia Ahmed ◽

Aymen Naeem ◽

Bisma Zahid ◽

Moizza Tahir ◽

Uzma Bashir ◽

...

Keyword(s):

Quality Of Life ◽

Cutaneous Leishmaniasis ◽

Tertiary Care ◽

Multicentric Study ◽

Tertiary Care Hospitals

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Impact of molecular alterations on quality of life and prognostic understanding over time in patients with incurable lung cancer: a multicenter, longitudinal, prospective cohort study

Supportive Care in Cancer ◽

10.1007/s00520-021-06736-2 ◽

2021 ◽

Author(s):

Jonas Kuon ◽

Miriam Blasi ◽

Laura Unsöld ◽

Jeannette Vogt ◽

Anja Mehnert ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Psychological Distress ◽

Performance Status ◽

Multicentric Study ◽

Molecular Alterations ◽

Prospective Longitudinal ◽

The Impact ◽

Over Time

Abstract Purpose The purpose of this study is to investigate changes over time in quality of life (QoL) in incurable lung cancer patients and the impact of determinants like molecular alterations (MA). Methods In a prospective, longitudinal, multicentric study, we assessed QoL, symptom burden, psychological distress, unmet needs, and prognostic understanding of patients diagnosed with incurable lung cancer at the time of the diagnosis (T0) and after 3 (T1), 6 (T2) and 12 months (T3) using validated questionnaires like FACT-L, National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT), PHQ-4, SCNS-SF-34, and SEIQoL. Results Two hundred seventeen patients were enrolled, 22 (10%) with reported MA. QoL scores improved over time, with a significant trend for DT, PHQ-4, and SCNS-SF-34. Significant determinants for stable or improving scores over time were survival > 6 months, performance status at the time of diagnosis, and presence of MA. Patients with MA showed better QoL scores (FACT-L at T1 104.4 vs 86.3; at T2 107.5 vs 90.0; at T3 100.9 vs 92.8) and lower psychological distress (NCCN DT at T1 3.3 vs 5; at T2 2.7 vs 4.5; at T3 3.7 vs 4.5; PHQ-4 at T1 2.3 vs 4.1; at T2 1.7 vs 3.6; at T3 2.2 vs 3.6), but also a worsening of the scores at 1 year and a higher percentage of inaccurate prognostic understanding (27 vs 17%) compared to patients without MA. Conclusion Patients with tumors harboring MA are at risk of QoL deterioration during the course of the disease. Physicians should adapt their communication strategies in order to maintain or improve QoL.

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Validation of the Spanish version of the Oxford knee score and assessment of its utility to characterize quality of life of patients suffering from knee osteoarthritis: a multicentric study

Health and Quality of Life Outcomes ◽

10.1186/s12955-017-0761-2 ◽

2017 ◽

Vol 15 (1) ◽

Cited By ~ 7

Author(s):

Jesús Martín-Fernández ◽

Roberto García-Maroto ◽

Fco Javier Sánchez-Jiménez ◽

Alonso Bau-González ◽

Homero Valencia-García ◽

...

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

Oxford Knee Score ◽

Spanish Version ◽

Knee Score ◽

Multicentric Study

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P523 Improvement of quality of life and continence in patients with distal ulcerative colitis treated by mesalazine: QUARTZ study

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.651 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S451-S451

Author(s):

T Paupard ◽

F Gonzalez ◽

L Siproudhis ◽

L Peyrin-Biroulet

Keyword(s):

Quality Of Life ◽

Ulcerative Colitis ◽

Functional Disability ◽

Primary Objective ◽

Induction Treatment ◽

Public And Private ◽

Multicentric Study ◽

Distal Ulcerative Colitis ◽

Mayo Score

Abstract Background There is no robust data which analysed quality of life, functional disability and continence of patients with distal UC. QUARTZ is the first prospective study in this situation. Methods Observational, prospective and multicentric study involving public and private French gastroenterologist to recruit patients with mild to moderate (Mayo score ≥ 3 and ≤ 10) active proctitis or proctosigmoiditis (<20 cm) and under mesalazine for induction treatment. The patients followed for 12 months (±2 months). The primary objective was the quality of life evaluated by Short Inflammatory Bowel Disease (SIBDQ) at 8 weeks (±4 months). The functional disability and incontinence have been evaluated by IBD-Disability Index and Cleveland questionnaires. Results From December 2015 to November 2016, 117 patients were recruited. Data of 93 patients have been analysed and results are reported on Table 1. Among the 93 patients, 75 (81%) reached a clinical remission at week 8 with a SIBDQ score improvement of 6.7 ± 7.1 point (p < 0,001). Treatment adherence during the induction period was non-compliance for 76 patients (81%): 17 (18%) patients stopped treatment before W8 (all those patients received rectal formulation). After induction treatment, 72 (77%) patients received maintenance treatment. 11 (12%) patients reported adverse event not linked to the treatment. Conclusion For patients with distal ulcerative colitis treated by mesalazine, quality of life, functional disability and continence have been improved at 8 weeks of treatment despite a poor adherence.

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Clinical Outcome after the Use of a New Craniocaudal Expandable Implant for Vertebral Compression Fracture Treatment: One Year Results from a Prospective Multicentric Study

BioMed Research International ◽

10.1155/2015/927813 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

David Noriega ◽

Antonio Krüger ◽

Francisco Ardura ◽

Nils Hansen-Algenstaedt ◽

Frank Hassel ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Oswestry Disability Index ◽

Clinical Performance ◽

Compression Fracture ◽

Cement Leakage ◽

Vertebral Compression Fractures ◽

Multicentric Study ◽

Pmma Bone Cement

The purpose of this prospective multicentric observational study was to confirm the safety and clinical performance of a craniocaudal expandable implant used in combination with high viscosity PMMA bone cement for the treatment of vertebral compression fractures. Thirty-nine VCFs in 32 patients were treated using the SpineJack minimally invasive surgery protocol. Outcome was determined by using the Visual Analogue Scale for measuring pain, the Oswestry Disability Index for scoring functional capacity, and the self-reporting European Quality of Life scores for the quality of life. Safety was evaluated by reporting all adverse events. The occurrence of cement leakages was assessed by either radiographs or CT scan or both. Statistically significant improvements were found regarding pain, function, and quality of life. The global pain score reduction at 1 year was 80.9% compared to the preoperative situation and the result of the Oswestry Disability Index showed a decrease from 65.0% at baseline to 10.5% at 12 months postoperatively. The cement leakage rate was 30.8%. No device- or surgery-related complications were found. This observational study demonstrates promising and persistent results consisting of immediate and sustained pain relief and durable clinical improvement after the procedure and throughout the 1-year follow-up period.

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Short Daily versus Conventional Hemodialysis Quality of Life: A Cross-Sectional Multicentric Study in Spain

Blood Purification ◽

10.1159/000227784 ◽

2009 ◽

Vol 28 (3) ◽

pp. 159-164 ◽

Cited By ~ 6

Author(s):

J. Puñal Rioboó ◽

E. Sánchez-Iriso ◽

A. Ruano-Ravina ◽

M.L. Varela Lema ◽

D. Sánchez-Guisande ◽

...

Keyword(s):

Quality Of Life ◽

Cross Sectional ◽

Multicentric Study ◽

Conventional Hemodialysis

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Multicentric study of epidemiological and clinical characteristics of persons injured in motor vehicle accidents in Medellín, Colombia, 2009-2010

Colombia Medica ◽

10.25100/cm.v44i2.1106 ◽

2013 ◽

pp. 100-107 ◽

Cited By ~ 6

Author(s):

Luz Helena Lugo ◽

Héctor Iván García ◽

Blanca Cecilia Cano ◽

Juan Carlos Arango Lasprilla ◽

Olga Lucia Alcaraz

Keyword(s):

Quality Of Life ◽

Clinical Characteristics ◽

Traffic Accidents ◽

Injury Severity ◽

Motor Vehicle ◽

Public Health Problem ◽

Severe Trauma ◽

Mitigation Strategies ◽

Multicentric Study

Introduction: Traffic accidents (TA) cause 1.23 million deaths each year worldwide while between 20 and 50 million persons are injured each year. In 2011 in Medellin, Colombia, there were 307 traffic deaths and 23,835 injured with 411 accidents for each 10,000 vehicles. Objective: The purpose of the study was to describe the epidemiologic and clinical characteristics, as well as the quality of life and disability outcomes for those injured in traffic accidents in Medellin. Methods: This prospective, descriptive, cross-sectional study collected data from 834 patients that were classified with the New Injury Severity Score (NISS) , the WHODAS-II (Disability Assessment) Scale and the SF-36 Health Survey. Results: Three-fourths (75.8%) of the patients were male. Eightyone percent of patients were involved in motorcycle accidents, with 45.6% suffering moderate trauma, and 32.6% experiencing severe trauma. Of the patients with severe trauma, 8.5% were not wearing helmets. Half of the sample (49.7%) injured their extremities. The WHODAS-II domains most affected were: Activities outside the home (62.0 %), Housework (54.3%) and Moving in one’s environment (45.2 %). Quality of life areas affected were: Physical role (20.3%), Body pain (37.3 %) Emotional role (44.1%), Physical functioning (52.6 %). Conclusions: Patients with more severe injuries had higher levels of disability and a worse quality of life. Motorcycles made up a large proportion of traffic accidents in this city and mitigation strategies to reduce this public health problem should particularly focus on this high-risk group.

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