Causal associations of waist circumference and waist-to-hip ratio with type II diabetes mellitus: new evidence from Mendelian randomization

Author(s):  
Kexin Li ◽  
Tianyu Feng ◽  
Lijuan Wang ◽  
Yang Chen ◽  
Pingping Zheng ◽  
...  
2019 ◽  
Vol 7 (1) ◽  
pp. 50-52 ◽  
Author(s):  
I Made Pande Dwipayana ◽  
I Made Siswadi Semadi ◽  
Wira Gotera ◽  
Made Ratna Saraswati ◽  
Ketut Suastika

BACKGROUND: Vaspin concentration was thought to be associated with obesity, impaired insulin sensitivity, and fitness level. The correlation of vaspin and leptin supports the theory of vaspin associated with body fat mass. AIM: To determine the correlation between visceral fat distributions and serum vaspin level in type II DM patients. METHODS: We conduct an observational, analytical cross-sectional study. Sixty subjects with type II diabetes mellitus who came to Diabetes Center of Sanglah General Hospital were included consecutively. Each subject has to sign an informed consent before physical and laboratory examination took place. Spearman correlation test was used to analyse the correlation between waist circumference and visceral fat percentage with serum vaspin level since the data were not distributed normally. RESULTS: Mean laboratory results in all subjects of vaspin levels was 2.389 ± 3.586 ng/ml, mean waist circumference was 94.95 ± 11.78 cm and mean visceral fat percentage was 18.05 ± 23.63%. We found we found no significant correlation between between vaspin with waist circumference (r = -0.044; p = 0.738) and visceral fat percentage (r = -0.103; p = 0.435). CONCLUSIONS: The vaspin level did not significantly correlate with waist circumference and visceral fat percentage in type II diabetes patients.


2016 ◽  
Vol 51 (3) ◽  
pp. 177
Author(s):  
Misbakhul Munir ◽  
Ari Sutjahjo ◽  
Florentina Sustini

Obesity, especially central obesity is often associated with insulin resistance and type 2 diabetes mellitus. Diabetes mellitus is a disease of the number six cause of death in Indonesia with the proportion of deaths by 5.8%. The purpose of this study was to identify central obesity in patients with type 2 diabetes mellitus in Poly Endocrine Dr. Soetomo Hospital, Surabaya. The study design was descriptive study. The sample was 100 type 2 diabetes mellitus patients taken with purposive sampling technique. The variable was central obesity and type 2 diabetes mellitus. The data obtained by interviewing patients and performing measurements on body weight, height and waist circumference. Data were analyzed by interpreting how the description of the variables studied and compared with other studies and theories. The results was the characteristics of patients most were female (66%), level of education was medium, unemployment, most of patient’s age was more than 50 years old, 43% for interval 51-60 years old, 43% were 1,50-1,59 meters in height and 28% were 50-59 kilograms and 28% were 60-69 kilograms in weight. According to Body Mass Index (BMI) measure that 54% the patients are normal in average 25,56 8,12 kg/m2. Measurement of waist circumference showed that 73.5% male and 81.8% female patients had central obesity. The conclusions, precentage of patients with type II diabetes mellitus who have central obesity were 81,82% female and 73, 53% male.


2006 ◽  
Vol 76 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Siriporn Chanchay ◽  
Rungsunn Tungtrongchitr ◽  
Talabporn Harnroongroj ◽  
Benjaluck Phonrat ◽  
Orapin Rungseesakorn ◽  
...  

This study investigated levels of fasting plasma glucose (FBS), homeostasis model of the assessment of the insulin resistance (HOMA), lipid profile, insulin, and resistin hormones in 202 individuals, divided into four groups. Two groups had type II diabetes mellitus (DM): one group had been overnourished (DM/OB) (body mass index: BMI equal or above 25) and the other had not (DM/nOB). Two additional groups not suffering from diabetes were either overnourished (nDM/OB) or of normal nutritional status (nDM/nOB). Only the DM/OB group had insulin levels elevated above the other three groups. Resistin levels had been lowest in the nDM/nOB group. When participants of the two nOB groups were pooled into one group and the subjects of the two OB groups were combined into another group, the median plasma resistin levels of the OB groups were significantly higher compared with the nOB groups. Likewise the DM groups had higher resistin levels than the nDM groups. A significant correlation of plasma resistin with BMI, waist circumference, waist-to-hip ratio, FBS, and HOMA score had been observed. The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.


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