Histological differentiation of mucus cell subtypes suggests functional compartmentation in the eel esophagus

2020 ◽  
Vol 380 (3) ◽  
pp. 499-512 ◽  
Author(s):  
Marty Kwok-Shing Wong ◽  
Mizuki Uchida ◽  
Takehiro Tsukada
Keyword(s):  
Histological Differentiation ◽  
Mucus Cell

scholarly journals A Case Report of Primordial Odontogenic Tumor That Required Distinction from a Dentigerous Cyst

Reports ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 4
Author(s):  
Sawako Ono ◽  
Hotaka Kawai ◽  
Shintaro Sukegawa ◽  
Kiyofumi Takabatake ◽  
Keisuke Nakano ◽  
...  
Keyword(s):  
Root Resorption ◽  
Dentigerous Cyst ◽  
Fibrous Tissue ◽  
Clinical Findings ◽  
Odontogenic Tumor ◽  
Columnar Epithelium ◽  
Solid Mass ◽  
Histological Differentiation ◽  
Second Molar ◽  
Primordial Odontogenic Tumor

Primordial odontogenic tumor (POT) is a rare odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla and covered by cuboidal to columnar epithelium. We herein report a case of POT in a 14-year-old boy. Computed tomography (CT) exhibited a round cavity with a defined cortical border circumscribing the tooth of the second molar. However, the gross finding was a solid mass, not a cyst. Histologically, the tumor consisted of dental papillalike myxoid connective tissue covered by columnar epithelium. Therefore, although the clinical diagnosis was dentigerous cyst (DC), we diagnosed POT based on histologic findings. Clinical findings of POT resemble DC, but the clinical behavior of POT is different to DC, such as cortical expansion and root resorption of teeth. Therefore, histological differentiation of POT from DC is critical for accurate diagnosis.

scholarly journals Primary Soft Tissue Sarcoma of the Heart: An Emerging Chapter in Cardio-Oncology

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 774
Author(s):  
Pietro Scicchitano ◽  
Maria Chiara Sergi ◽  
Matteo Cameli ◽  
Marcelo H. Miglioranza ◽  
Marco Matteo Ciccone ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Soft Tissue Sarcomas ◽  
Cardiac Tumors ◽  
Malignant Cells ◽  
Future Perspectives ◽  
Histological Differentiation ◽  
Biological Features ◽  
Literature Overview ◽  
Primary Localization

Primary malignant cardiac tumors are rare, with a prevalence of about 0.01% among all cancer histotypes. At least 60% of them are primary soft tissue sarcomas of the heart (pSTS-h) that represent almost 1% of all STSs. The cardiac site of origin is the best way to classify pSTS-h as it is directly linked to the surgical approach for cancer removal. Indeed, histological differentiation should integrate the classification to provide insights into prognosis and survival expectancy of the patients. The prognosis of pSTS-h is severe and mostly influenced by the primary localization of the tumor, the difficulty in achieving complete surgical and pharmacological eradication, and the aggressive biological features of malignant cells. This review aims to provide a detailed literature overview of the most relevant issues on primary soft tissue sarcoma of the heart and highlight potential diagnostic and therapeutic future perspectives.

MR imaging of intraspinal tumors?Capability in histological differentiation and compartmentalization of extramedullary tumors

1988 ◽  
Vol 30 (4) ◽  
pp. 303-309 ◽  
Author(s):  
K. Takemoto ◽  
Y. Matsumura ◽  
H. Hashimoto ◽  
Y. Inoue ◽  
T. Fukuda ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Histological Differentiation

scholarly journals Circulating Tumor Cells Counting Act as a Potential Prognostic Factor in Cervical Cancer

2020 ◽  
Vol 19 ◽  
pp. 153303382095700 ◽  
Author(s):  
Kunpeng Du ◽  
Qian Huang ◽  
Junguo Bu ◽  
Jieling Zhou ◽  
Zijian Huang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factor ◽  
Progression Free Survival ◽  
Disease Stage ◽  
Histological Differentiation ◽  
Free Survival ◽  
Pathological Type ◽  
Negative Prognostic Factor ◽  
The Relationship ◽  
Independent Negative Prognostic Factor

Background: Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required. Objective: This study investigated whether CTCs were detectable in patients with cervical cancer and whether CTC count was an indicator of prognosis. Methods: We enrolled 107 patients with pathologically confirmed cervical cancer. CTCs were detected after radiotherapy or concurrent cisplatin-containing chemotherapy in all patients. We evaluated all medical records and imaging data as well as follow-up information to calculate progression-free survival (PFS). PFS was defined as the time until first diagnosis of tumor progression or death. We also analyzed the relationship between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Results: CTCs were identified in 86 of 107 patients (80%), and the CTC count ranged from 0 to 27 cells in 3.2 mL blood. The median progression-free survival (PFS) was 43.1 months. Patients in which CTCs were detected had a significantly shorter PFS than CTC-negative patients (P = 0.018). Multivariate analysis indicated that CTC count was an independent negative prognostic factor for survival. However, no correlation was observed between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Conclusion: CTC count is an independent negative prognostic factor for cervical cancer.

Clinical significance of E-cadherin, β-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma

2013 ◽  
Vol 66 (11) ◽  
pp. 937-945 ◽  
Author(s):  
Hua Zhang ◽  
Jun Liu ◽  
Dongsheng Yue ◽  
Liuwei Gao ◽  
Daowei Wang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Squamous Cell Lung Carcinoma ◽  
Histological Differentiation ◽  
Vimentin Expression ◽  
Cell Lung Carcinoma ◽  
Node Metastasis ◽  
S100a4 Expression ◽  
E Cadherin

ObjectiveThe aim of this study was to evaluate the prognostic value of E-cadherin, β-catenin, vimentin and S100A4 expression in a cohort of squamous cell lung carcinoma (SqCC) patients.MethodsTumours from 204 patients with surgically resected SqCC were used for the immunohistochemical analyses of E-cadherin, β-catenin, vimentin and S100A4 expression. Correlations between the expression of these markers and clinicopathological parameters were analysed using the χ2 test. The prognostic value of these markers was evaluated using univariate Kaplan–Meier survival analyses and multivariate Cox proportional hazards model analyses.ResultsSignificant associations between E-cadherin expression and T stage (p=0.040), histological differentiation (p=0.005), lymph node metastasis (p<0.001), and recurrence (p<0.001) were identified. Decreased β-catenin expression was significantly correlated with T stage (p=0.003) and lymph node metastasis (p=0.010). Vimentin expression was associated with histological differentiation (p=0.017) and lymph node metastasis (p=0.001). Moreover, significant correlations were observed between S100A4 expression and lymph node metastasis (p=0.020) and recurrence (p<0.001). In the univariate analyses, high E-cadherin expression was a positive indicator for overall survival (OS) (p<0.001) and disease-free survival (DFS) (p<0.001), whereas high S100A4 or vimentin expression were negative indicators for OS (p<0.001 and p=0.010, respectively) and DFS (p<0.001 and p=0.006, respectively). In the multivariate analyses, E-cadherin and S100A4 expression were independent prognostic factors for OS (HR 0.697, 95% CI 0.524 to 0.926, p=0.013, and HR 1.508, 95% CI 1.122 to 2.027, p=0.007, respectively) and DFS (HR 0.634, 95% CI 0.471 to 0.852, p=0.003, and HR 1.490, 95% CI 1.101 to 2.015, p=0.010, respectively).ConclusionsEffective analysis of E-cadherin and S100A4 expression may allow for the identification of patients who are at a high risk of recurrence and poor prognosis in SqCC.

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