Age-specific response of the grass Puccinellia distans to the presence of a fungal endophyte

Oecologia ◽  
2007 ◽  
Vol 152 (3) ◽  
pp. 485-494 ◽  
Author(s):  
Paweł Olejniczak ◽  
Marlena Lembicz
Flora ◽  
2017 ◽  
Vol 228 ◽  
pp. 60-64 ◽  
Author(s):  
Karolina Górzyńska ◽  
Przemysław Ryszka ◽  
Teresa Anielska ◽  
Katarzyna Turnau ◽  
Marlena Lembicz

Plant Disease ◽  
2018 ◽  
Vol 102 (10) ◽  
pp. 1973-1980 ◽  
Author(s):  
Karolina Górzyńska ◽  
Magdalena Ślachetka ◽  
Przemysław Ryszka ◽  
Katarzyna Turnau ◽  
Bartosz J. Płachno ◽  
...  

Fungi of the genus Epichloë (Clavicipitaceae, Ascomycota) cause choke disease in many grass species. The disease manifests itself as fungal stromata that form around developing inflorescences, thereby suppressing their maturation. Economic losses in agricultural production due to choke have long been known in the U.S.A. and France, but attempts to control choke disease have not been successful. The interaction between Epichloë typhina (Pers.) Tul. & C. Tul. and its naturally occurring fungal hyperparasite, Clonostachys epichloë (Speg.) Schroers (sexual morph Bionectria epichloë) was investigated in populations of the grass Puccinellia distans (L.) Parl. Fungal hyperparasites occur widely in nature, and many are successfully used commercially as biological control agents against plant pathogenic fungi. Microscopy of Epichloë stromata infected with C. epichloë revealed a lack of asci with ascospores in perithecia and damage to mycelia at sites colonized by C. epichloë. The ability of C. epichloë to colonize E. typhina was confirmed via two in vitro experiments. The percent inhibition of growth of E. typhina strains by C. epichloë varied from 18.40 to 46.50%, and the mycoparasite colonized up to 100% of Epichloë mycelia in a precolonization experiment. We discuss the possibility of using C. epichloë to control choke disease caused by E. typhina in grass populations.


Romanticism ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 157-166
Author(s):  
Nikki Hessell

John Keats's medical studies at Guy's Hospital coincided with a boom in interest in both the traditional medicines of the sub-continent and the experiences of British doctors and patients in India. Despite extensive scholarship on the impact of Keats's medical knowledge on his poetry, little consideration has been given to Keats's exposure to Indian medicine. The poetry that followed his time at Guy's contains numerous references to the contemporary state of knowledge about India and its medical practices, both past and present. This essay focuses on Isabella and considers the major sources of information about Indian medicine in the Regency. It proposes that some of Keats's medical imagery might be read as a specific response to the debates about medicine in the sub-continent.


Author(s):  
Zoran Vrucinic

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.


Author(s):  
Ajay Bhushan Prasad

21<sup>st</sup> Century is an era of stress and burnout. For the past few decades it has been a burning and hot topic of discussion for researchers, to evolve stress and burnout- from a global problem to global solutions, as it affects the life of individuals in an unprecedented manner and touches them at workplace across the globe. Everybody knows what stress is all about. It has become a part of life and perhaps, to some extent, necessary at work and outside work. Some people are more productive and creative when they work under stress. But if stress is intense and continuous, then it becomes a negative phenomenon leading to physical illness and psychological disorders. Stress and burnout in today's environment has become a well documented problem. Various researches have evaluated stress and burnout in workplaces. Stress is a non-specific response of body to any demand made on it. Many researchers have identified that stress and burnout has become an integral part of our daily life due to the negative aspects of job, such as, multiple responsibilities, disciplinary problems, employee's apathy, involuntary transfers, inadequate pay and perks, less chances of career advancement and lack of administrative support etc. As a result of these, individuals are likely to suffer from stress and may experience a sense of tiredness and frustration. When prolonged stress continues and it is not effectively managed, it can even lead to symptoms of burnout, a state of emotional exhaustion, depersonalization and diminished personal accomplishment in the workplace. Stress management can be done through six zones which we have discussed in detail, with a holistic approach. It includes health zone, intimate zone, family zone, work zone, social zone and spiritual zone. In this paper, an effort is made to discuss the solutions of stress and burnout in different and innovative ways through different zones which have been experienced by the author in his 20 years of professional career. Thus, stress and burnout are not a trivial problem but a major dysfunction of the 21<sup>st</sup> century, which has far reaching impact on quality and quantity of productivity. The present paper explores the concept of stress and burnout, the major differences between them, factors leading to genesis of the problem, various symptoms and how it is a serious quality concern for all professionals. Appropriate interventions for prevention and management of stress and burnout are also suggested.


RSC Advances ◽  
2019 ◽  
Vol 9 (47) ◽  
pp. 27419-27423 ◽  
Author(s):  
Chao Yuan ◽  
Hong-Xia Yang ◽  
Yu-Hua Guo ◽  
Lin Fan ◽  
Ying-Bo Zhang ◽  
...  

Four new α-pyrones, hypotiens A–D (1–4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera.


2021 ◽  
Vol 50 ◽  
pp. 16-24
Author(s):  
Pablo Adrián García-Parisi ◽  
Sebastián Aníbal Gavilán ◽  
Cecilia Casas ◽  
Pedro Emilio Gundel ◽  
Marina Omacini

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2396
Author(s):  
Nina Schoenwaelder ◽  
Inken Salewski ◽  
Nadja Engel ◽  
Mareike Krause ◽  
Björn Schneider ◽  
...  

Cyclin-dependent kinase inhibitors (CDKi´s) display cytotoxic activity against different malignancies, including head and neck squamous cell carcinomas (HNSCC). By coordinating the DNA damage response, these substances may be combined with cytostatics to enhance cytotoxicity. Here, we investigated the influence of different CDKi´s (palbociclib, dinaciclib, THZ1) on two HNSCC cell lines in monotherapy and combination therapy with clinically-approved drugs (5-FU, Cisplatin, cetuximab). Apoptosis/necrosis, cell cycle, invasiveness, senescence, radiation-induced γ-H2AX DNA double-strand breaks, and effects on the actin filament were studied. Furthermore, the potential to increase tumor immunogenicity was assessed by analyzing Calreticulin translocation and immune relevant surface markers. Finally, an in vivo mouse model was used to analyze the effect of dinaciclib and Cisplatin combination therapy. Dinaciclib, palbociclib, and THZ1 displayed anti-neoplastic activity after low-dose treatment, while the two latter substances slightly enhanced radiosensitivity. Dinaciclib decelerated wound healing, decreased invasiveness, and induced MHC-I, accompanied by high amounts of surface-bound Calreticulin. Numbers of early and late apoptotic cells increased initially (24 h), while necrosis dominated afterward. Antitumoral effects of the selective CDKi palbociclib were weaker, but combinations with 5-FU potentiated effects of the monotherapy. Additionally, CDKi and CDKi/chemotherapy combinations induced MHC I, indicative of enhanced immunogenicity. The in vivo studies revealed a cell line-specific response with best tumor growth control in the combination approach. Global acting CDKi’s should be further investigated as targeting agents for HNSCC, either individually or in combination with selected drugs. The ability of dinaciclib to increase the immunogenicity of tumor cells renders this substance a particularly interesting candidate for immune-based oncological treatment regimens.


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