Psychometric testing of the Impact of Event Scale-Chinese Version (IES-C) in oral cancer patients in Taiwan

Background and objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan–Meier analysis and the Cox proportional hazard model. Results: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. Conclusions: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.

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EMDR and CBT for Cancer Patients: Comparative Study of Effects on PTSD, Anxiety, and Depression

Journal of EMDR Practice and Research ◽

10.1891/1933-3196.7.3.134 ◽

2013 ◽

Vol 7 (3) ◽

pp. 134-143 ◽

Cited By ~ 38

Author(s):

Liuva Capezzani ◽

Luca Ostacoli ◽

Marco Cavallo ◽

Sara Carletto ◽

Isabel Fernandez ◽

...

Keyword(s):

Cancer Patients ◽

Active Treatment ◽

Behavioral Therapy ◽

Treatment Phase ◽

Anxiety And Depression ◽

Impact Of Event Scale ◽

Event Scale ◽

Active Treatment Phase ◽

The Impact

This pilot study examined the efficacy of eye movement desensitization and reprocessing (EMDR) treatment compared with cognitive behavioral therapy (CBT) in treating posttraumatic stress disorder (PTSD) in oncology patients in the follow-up phase of the disease. The secondary aim of this study was to assess whether EMDR treatment has a different impact on PTSD in the active treatment or during the follow-up stages of disease. Twenty-one patients in follow-up care were randomly assigned to EMDR or CBT groups, and 10 patients in the active treatment phase were assigned to EMDR group. The Impact of Event Scale—Revised (IES-R) and Clinician-Administered PTSD Scale (CAPS) were used to assess PTSD at pretreatment and 1 month posttreatment. Anxiety, depression, and psychophysiological symptoms were also evaluated. For cancer patients in the follow-up stage, the absence of PTSD after the treatment was associated with a significantly higher likelihood of receiving EMDR rather than CBT. EMDR was significantly more effective than CBT in reducing scores on the IES-R and the CAPS intrusive symptom subscale, whereas anxiety and depression improved equally in both treatment groups. Furthermore, EMDR showed the same efficacy both in the active cancer treatment and during the follow-up of the disease.

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The impact of comorbidities on survival in oral cancer patients: a population-based, case-control study

Acta Oncologica ◽

10.1080/0284186x.2020.1836393 ◽

2020 ◽

pp. 1-7

Author(s):

Mustafa Ghanizada ◽

Kathrine Kronberg Jakobsen ◽

Jakob Schmidt Jensen ◽

Irene Wessel ◽

Jesper Filtenborg Tvedskov ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Patients ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Oral Cancer Patients ◽

The Impact ◽

Control Study

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Post-traumatic stress symptoms in cancer patients during the COVID-19 pandemic: a one-year longitudinal study

10.1101/2022.01.11.22269053 ◽

2022 ◽

Author(s):

Etienne Bastien ◽

Sophie Lefevre-Arbogast ◽

Justine Lequesne ◽

Francois Gernier ◽

Francois Cherifi ◽

...

Keyword(s):

Cancer Patients ◽

Traumatic Stress ◽

Hematologic Malignancy ◽

Ptsd Symptoms ◽

Post Traumatic Stress ◽

Impact Of Event Scale ◽

Event Scale ◽

Post Traumatic ◽

One Year ◽

The Impact

Background: Cancer patients may be particularly vulnerable to psychological consequences of the COVID-19 pandemic and successive lockdowns. We studied the prevalence and evolution of post-traumatic stress disorder (PTSD) symptoms in cancer patients during the pandemic waves, and investigated factors associated with high symptoms. Methods: COVIPACT is a one-year longitudinal prospective study of French patients with solid/hematologic malignancy receiving treatment during the first nationwide lockdown. PTSD symptoms were measured every 3 months from April 2020 using the Impact of Event Scale-Revised. Patients also completed validated questionnaires on quality of life (QoL), cognitive complaints and insomnia, and a survey on their COVID-19 lockdown experience. Results: Longitudinal analyses involved 386 patients with at least one PTSD assessment after baseline (median age 63, 76% female). Among them, 21.5% had moderate/severe PTSD symptoms during the first lockdown. The rate of patients reporting PTSD symptoms decreased at lockdown release (13.6%), increased again at second lockdown (23.2%), and slightly declined from the second release period (22.7%) to the third lockdown (17.5%). Patients were grouped into three trajectories of evolution. Most patients had stable low symptoms throughout the period, 6% had high baseline symptoms slowly decreasing over time, and 17.6% had moderate symptoms worsening during second lockdown. Female sex, feeling socially isolated, worrying about COVID-19 infection, and using psychotropic drugs were associated with PTSD symptoms. PTSD symptoms were associated with impaired QoL, sleep and cognition. Conclusions: Around a quarter of cancer patients presented high and persistent PTSD symptoms over the first year of the COVID-19 pandemic and may benefit from psychological support.

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THE EXPERIENCES OF ORAL CANCER PATIENTS: A NARRATIVE REVIEW

Malaysian Journal of Public Health Medicine ◽

10.37268/mjphm/vol.21/no.2/art.902 ◽

2021 ◽

Vol 21 (2) ◽

pp. 168-177

Author(s):

Maria Ishaq Khattak ◽

Muslim Khan ◽

Saad Ishaq Khattak ◽

Zohaib Khan ◽

Zia Ul Haq ◽

...

Keyword(s):

Quality Of Life ◽

Oral Cancer ◽

Cancer Patients ◽

Social Experiences ◽

Current Evidence ◽

Mouth Neoplasms ◽

Social Avoidance ◽

Oral Cancer Patients ◽

The Impact

This is a critical review of the current evidence on patients’ experiences with oral cancer. The impact on the quality of life and implications to clinical practice and research were also discussed. A comprehensive search of three databases, PubMed, Scopus, and Google Scholar was undertaken. The search was restricted to English-language primary research papers from 2009 till 2019. The following keywords were used: mouth neoplasms, patients, experiences, oral cancer, physical, social, psychological. A total of 173 studies were retrieved using the search strategy. After removing duplicate reports and scrutinising those based on title and abstract, 68 studies were shortlisted for full text review. Three major themes emerged from the literature: (1) physical experiences of oral cancer patients, (2) psychological experiences of oral cancer patients, and (3) social experiences of oral cancer patients. Experiences of oral cancer patients are complex and subjective, and phases of physical, psychological, and social experiences of oral cancer have not been explored in detail. However, there is evidence that experiences such as pain, facial alterations, body image disturbances, anxiety, depression, social avoidance, social support, and financial implications affect patients’ quality of life. This review underlines the importance of further research to look into the type of support needed to address various experiences of oral cancer patients.

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