Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract

2020 ◽  
Vol 29 (6) ◽  
pp. 1179-1187
Author(s):  
Ganiu Jimoh Akorede ◽  
Suleiman Folorunsho Ambali ◽  
Mikail Garba Hudu ◽  
Mohammed M. Suleiman ◽  
Kolawole Yusuf Suleiman ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Methanolic Extract ◽  
Reproductive Toxicity ◽  
Protective Properties ◽  
Male Wistar Rats ◽  
Moringa Oleifera Leaves

Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats

2013 ◽  
Vol 24 (4) ◽  
Author(s):  
Ademola A. Oyagbemi ◽  
Temitayo O. Omobowale ◽  
Ibraheem O. Azeez ◽  
John O. Abiola ◽  
Rahamon A.M. Adedokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Methanolic Extract ◽  
Male Wistar Rats ◽  
Liver And Kidney ◽  
Moringa Oleifera Leaves

Biochemical, Hematological and Histopathological Indices of Wistar Rats Fed Vitamin and Mineral Deficient Diets Supplemented with Moringa oleifera Leaf Meal

2019 ◽  
Vol 15 (6) ◽  
pp. 608-620
Author(s):  
Yanga N. Mhlomi ◽  
Gloria A. Otunola ◽  
Anthony J. Afolayan
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Control Group ◽  
Marker Enzymes ◽  
High Increase ◽  
Leaf Meal ◽  
Male Wistar Rats ◽  
Moringa Oleifera Leaves ◽  
Normal Rat ◽  
And Control

Background: Moringa oleifera is currently and rapidly gaining superfood status. Objective: This study evaluated the effect of Moringa oleifera leaves (MOLM) on haematological, biochemical and histopathology indices of rats fed with Vitamins and Minerals Deficient (VMD) diets. Methods: Twenty-five male Wistar rats (220-290g) were randomly assigned into 5 groups of 5 rats each. The control (normal rat chow), remaining four diets were VMD plus MOLM at 0, 3, 5 and 10%. Haematological, biochemical and histopathological statuses were evaluated after 28 days. Results: Non-significant increase in RBC was observed in rats fed with the MOLM diets compared to control. Rats on VMD diet had the lowest haemoglobin levels, whereas haemoglobin increased with MOLM. No significant differences were observed in haematocrit, MCH, MCHC, platelets, RDW and MPV in all the treatments and control group. However, VMD rats showed a decrease in haemoglobin, and an increase in WBC and platelets. Electrolytes and glucose for all the treatments and control were not significantly different, but, control and VMD10 diets rats showed significantly higher values for creatinine compared to MOLM diets; total protein and albumin increased with MOLM and were higher than in VMD and control rats. Serum activities of hepatic, cardiac and adrenal marker enzymes were observed to be significantly lower in MOLM rats compared to VMD and control. Mild congestion in VMD and VMD3 rats’ liver and diffused congestion in the kidney of VMD diet rats were observed. Conclusion: The significantly high increase in platelet count in the VMD treated rats, indicative of anemia and other physiological imbalances, highlights the effect of micronutrient (mineral and vitamins) deficiencies in the diet. There is also the possibility that the anti-nutrients factors present in Moringa oleifera prevented uptake and bioavailability of nutrients, since the MOLM did not undergo any processing that could have removed or reduced these antinutrients. Further studies are still needed on Moringa oleifera leaves to validate the bioavailability of nutrients from the plant.

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

2019 ◽  
Vol 17 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Pierre Watcho ◽  
Ismaelle Rosine Mpeck ◽  
Patrick Brice Deeh Defo ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Beneficial Effects ◽  
Male Wistar Rats

scholarly journals Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

2016 ◽  
Vol 5 (5) ◽  
pp. 1465-1476 ◽  
Author(s):  
K. Pratap Reddy ◽  
Madamsetti Narayana Rao ◽  
J. S. R. Murthy ◽  
P. Sreenivasula Reddy
Keyword(s):  
Metabolic Disorder ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Lead Contamination ◽  
Contemporary Society ◽  
Male Wistar Rats

Diabetes, an unresolved metabolic disorder, and lead contamination are prevalent problems in contemporary society.

Isolation of a novel compound (MIMO2) from the methanolic extract of Moringa oleifera leaves: protective effects against vanadium-induced cytotoxity

2017 ◽  
Vol 41 (3) ◽  
pp. 249-258 ◽  
Author(s):  
Olumayowa O. Igado ◽  
Jan Glaser ◽  
Mario Ramos-Tirado ◽  
Ezgi Eylül Bankoğlu ◽  
Foluso A. Atiba ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Methanolic Extract ◽  
Protective Effects ◽  
Moringa Oleifera Leaves
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