Effect of Citrullus lanatus Seeeds and Moringa oleifera Leaves on Glucose Level and Lipid Profile Parameters of Alloxan-Induced Diabetic Wistar Rats

2017 ◽  
Vol 6 (12) ◽  
Author(s):  
Ngaski A. A. ◽  
Maryam Muhammad ◽  
Mainasara A. S. ◽  
Nasiru Sulaiman ◽  
Muhammad Kabiru Dallatu ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Glucose Level ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Citrullus Lanatus ◽  
Moringa Oleifera Leaves

Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats

2013 ◽  
Vol 24 (4) ◽  
Author(s):  
Ademola A. Oyagbemi ◽  
Temitayo O. Omobowale ◽  
Ibraheem O. Azeez ◽  
John O. Abiola ◽  
Rahamon A.M. Adedokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Methanolic Extract ◽  
Male Wistar Rats ◽  
Liver And Kidney ◽  
Moringa Oleifera Leaves

scholarly journals Evaluation of lipid profile, antioxidant and immunity statuses of rabbits fed Moringa oleifera leaves

2020 ◽  
Author(s):  
Mosaab Ibrahim Salem ◽  
Azza El-Sebai ◽  
Samar Ali Elnagar ◽  
Ahmed Mohamed Abd El-hady
Keyword(s):  
Lipid Profile ◽  
Moringa Oleifera ◽  
Moringa Oleifera Leaves

scholarly journals Comparative Effects Between A Total Aqueous Extract and A Diet Enriched with Moringa oleifera Leaves in Wistar Rats with Anemia

2020 ◽  
pp. 35-41
Author(s):  
Jean-Baptiste N’Guessan OUSSOU ◽  
◽  
Narcisse Boua GNANGORAN ◽  
Aboubacar COULIBALY ◽  
Paul Angoué YAPO ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Moringa Oleifera Leaves

Biochemical, Hematological and Histopathological Indices of Wistar Rats Fed Vitamin and Mineral Deficient Diets Supplemented with Moringa oleifera Leaf Meal

2019 ◽  
Vol 15 (6) ◽  
pp. 608-620
Author(s):  
Yanga N. Mhlomi ◽  
Gloria A. Otunola ◽  
Anthony J. Afolayan
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Control Group ◽  
Marker Enzymes ◽  
High Increase ◽  
Leaf Meal ◽  
Male Wistar Rats ◽  
Moringa Oleifera Leaves ◽  
Normal Rat ◽  
And Control

Background: Moringa oleifera is currently and rapidly gaining superfood status. Objective: This study evaluated the effect of Moringa oleifera leaves (MOLM) on haematological, biochemical and histopathology indices of rats fed with Vitamins and Minerals Deficient (VMD) diets. Methods: Twenty-five male Wistar rats (220-290g) were randomly assigned into 5 groups of 5 rats each. The control (normal rat chow), remaining four diets were VMD plus MOLM at 0, 3, 5 and 10%. Haematological, biochemical and histopathological statuses were evaluated after 28 days. Results: Non-significant increase in RBC was observed in rats fed with the MOLM diets compared to control. Rats on VMD diet had the lowest haemoglobin levels, whereas haemoglobin increased with MOLM. No significant differences were observed in haematocrit, MCH, MCHC, platelets, RDW and MPV in all the treatments and control group. However, VMD rats showed a decrease in haemoglobin, and an increase in WBC and platelets. Electrolytes and glucose for all the treatments and control were not significantly different, but, control and VMD10 diets rats showed significantly higher values for creatinine compared to MOLM diets; total protein and albumin increased with MOLM and were higher than in VMD and control rats. Serum activities of hepatic, cardiac and adrenal marker enzymes were observed to be significantly lower in MOLM rats compared to VMD and control. Mild congestion in VMD and VMD3 rats’ liver and diffused congestion in the kidney of VMD diet rats were observed. Conclusion: The significantly high increase in platelet count in the VMD treated rats, indicative of anemia and other physiological imbalances, highlights the effect of micronutrient (mineral and vitamins) deficiencies in the diet. There is also the possibility that the anti-nutrients factors present in Moringa oleifera prevented uptake and bioavailability of nutrients, since the MOLM did not undergo any processing that could have removed or reduced these antinutrients. Further studies are still needed on Moringa oleifera leaves to validate the bioavailability of nutrients from the plant.

scholarly journals Ameliorative Effect of <i>Moringa Oleifera</i> Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats

2021 ◽  
Vol 9 (1) ◽  
pp. 6
Author(s):  
Ibrahim Maina Hassan ◽  
Bashir Saidu ◽  
Ja’afaru Abdullahi Ishaq ◽  
Ashiru Dahiru ◽  
Nafisat Abdulazeez ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Biochemical Constituents ◽  
Ameliorative Effect

scholarly journals HISTOPATHOLOGICAL OF DIABETES MELLITUS WHITE RAT TESTICLE AFTER GIVEN MORINGA LEAF EXTRACT

2018 ◽  
pp. 176
Author(s):  
Raodatul Jannah ◽  
Ni Luh Eka Setiasih ◽  
Putu Suastika
Keyword(s):  
Diabetes Mellitus ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
White Rats ◽  
Moringa Oleifera Leaves ◽  
Rat Strain ◽  
Testis Structure ◽  
Moringa Leaf Extract

This study aimed to determine changes in testicular histopathological of the rat strain wistar diabetes mellitus experienced. This study used 24 white rats (Rattus norvegicus) strain Wistar which were divided into six groups: administration of Moringa oleifera leaves P1 (extract dose 0 mg/kg bw) , P2 (100 mg/kg bw) , P3 (200 mg/kg bw), P4 (300 mg/kg bw) , P5 (400 mg/kg bw)  and P6 ( 500 mg/kg bw) . In the end of administration, the diabetic Wistar rats were sacrificed and their testes were taken to make the histopathological preparations using haematoxylin and eosin staining. The observed variables are fat degeneration and necrosis. The results show that moringa leaves can improve histopathology testis structure of diabetes mellitus white rats. Extract of Moringa leaves (Moringa oleifera) dose of 400 mg/kg body weight has the best effect repair damage to the histopathological testis.

scholarly journals The effects of Moringa Oleifera on lipid profile status, heart histology, and liver histochemistry in adult Wistar rats

2017 ◽  
Vol 4 (2) ◽  
pp. 104 ◽  
Author(s):  
AdelajaAbdulazeez Akinlolu ◽  
ElizabethOluwafunmilayo Bayode ◽  
KamalOlaide Ghazali ◽  
MubarakOloduowo Ameen
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Moringa Oleifera

scholarly journals REGULATION OF ETHYL ACETATE FRACTION FROM MORINGA OLEIFERA LEAVES TO IMPROVE LIPID METABOLISM AND INSULIN SENSITIVITY IN TYPE 2 DIABETES

2018 ◽  
Vol 10 (10) ◽  
pp. 78
Author(s):  
Sholihatil Hidayati ◽  
Rini Sulistyawati ◽  
Laela Hayu Nurani
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethyl Acetate Fraction ◽  
Diabetic Rats ◽  
Moringa Oleifera Leaves

Objective: Moringa oleifera is a medicinal plant species that has potential as an antidiabetic. The present study was designed to evaluated molecullar mechanism antidiabetic ethyl acetate fraction of Moringa oleifera leaves (EAFML).Methods: The study was conducted on 30 male wistar rats which were induced with the combination of streptozotocin and nicotinamide by intraperitoneal administration to make a model of type 2 diabetes. After the diabetic induction, all rats were divided into six group and once daily administered orally EAFML in doses standardized quercetine. The treatment was given for ten days, and on the final treatment, all rats were checked their blood glucose level and lipid profile. The skeletal muscles and liver were taken to examine glucose transporter-4 (GLUT4) expression by immunohistochemistry.Results: The result of this study shows that the blood glucose level in diabetic rats with the treatment of EAFML decreased significantly from 355.8±83.7 mg/dL to 177.5±89.3 mg/dL. The cholesterol decreased significantly from 105.2±47.4 mg/dL to 58.6±6.9 mg/dL and low-density lipoprotein (LDL) in diabetic rats with the treatment of EAFML decreased significantly compared to control group from 175.6±41.9 mg/dL to 95.3±8.0 mg/dL. The expression of GLUT4 in skeletal muscles increased from 0.7±1.0 to 3.9±1.1 and in the liver increased significantly from 1.8±1.3 to 2.9±1.9.Conclusion: The EAFML can decrease blood glucose level, cholesterol and low-density lipoprotein in type 2 diabetic rat model. Other than that, this fraction can improve insulin sensitivity by the increase of GLUT4 expressions.

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