Experimental study of bone formation around a titanium rod with β- tricalcium phosphate and prostaglandin E2 receptor agonists

2005 ◽  
Vol 10 (3) ◽  
pp. 308-314 ◽  
Author(s):  
Michinaga Masuzawa ◽  
Moroe Beppu ◽  
Shoji Ishii ◽  
Yuichiro Oyake ◽  
Haruhito Aoki ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Formation ◽  
Prostaglandin E2 ◽  
Tricalcium Phosphate ◽  
Receptor Agonists ◽  
Prostaglandin E2 Receptor

EP4 Agonist Accelerates Osteoinduction and Degradation of β-Tricalcium Phosphate in Canine Model

2007 ◽  
Vol 361-363 ◽  
pp. 1021-1024
Author(s):  
Tomonori Nasu ◽  
Mitsuru Takemoto ◽  
Shunsuke Fujibayashi ◽  
Masashi Neo ◽  
Norihiro Akiyama ◽  
...  
Keyword(s):  
Bone Formation ◽  
Prostaglandin E2 ◽  
Tricalcium Phosphate ◽  
Canine Model ◽  
Rodent Model

Several kinds of biomaterials are known to possess osteoinductive ability without bone inductive substances in ectopic implantation. β-TCP is one such material that has been reported to exhibit this ability in a canine model. In addition, prostaglandin E2 has been proved to accelerate osteogenesis in a rodent model, and one of its receptors EP4 has been considered to play a particularly important role. We examined that the EP4 agonist accelerates β-TCP-induced osteoinduction in a canine model. The results suggested that the EP4 agonist accelerated not only osteoinduction but also osteoclastogenesis prior to bone formation.

Prostaglandin E2 receptor EP4-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation

2011 ◽  
Vol 650 (1) ◽  
pp. 396-402 ◽  
Author(s):  
Tadashi Ninomiya ◽  
Akihiro Hosoya ◽  
Toru Hiraga ◽  
Masanori Koide ◽  
Kojiro Yamaguchi ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Bone Formation ◽  
Prostaglandin E2 ◽  
Mesenchymal Cell ◽  
Selective Agonist ◽  
Prostaglandin E2 Receptor

scholarly journals Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor

2020 ◽  
Vol 123 (6) ◽  
pp. 955-964
Author(s):  
Kazuya Iwamoto ◽  
Hidekazu Takahashi ◽  
Daisuke Okuzaki ◽  
Hideo Osawa ◽  
Takayuki Ogino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Prostaglandin E2 Receptor
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