New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study

Introduction: Segmental bone defect can be treated with autologous bone graft and bone transport. Synthetic bone graft has successfully been used for the treatment of metaphyseal fracture or bone cyst. However, their use for the treatment of segmental bone defect has not been establish. Recently, a local company has produced a biodegradable custom made synthetic bone construct phosphate-based materials that is used to treat fractures and bone defect. Materials and Methods: After getting approval from Medical Device Agency, we used SBC to treat segmental bone defect in our patients. A case series review was conducted in these cases. Results: Three patients underwent surgery using SBC as a spacer to fill the defect at the docking site to prevent soft tissue collapse in one patient and as a replacement for bone autologous bone grafting in two patients. In our observation granules resorbtion ranged from 40-80% by 6 months with no radiological evidence of new bone formation. SBC mixed with bone marrow aspirate failed to harden into a palette. Although no new bone formation was seen at the docking site, insertion of SBC prevents soft tissue invagination and reduced the need of a second surgery to remove other conventional spacers. Conclusion: SBC may be used as a spacer to prevent soft tissue interposition and skin invagination in bone transport. However mixing it with bone marrow aspirate resulted in failure to form beads and does not form bone.

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Proposing a new design for segmental bone defect (SBD) tibial implant unit cell

IOP Conference Series Materials Science and Engineering ◽

10.1088/1757-899x/1114/1/012075 ◽

2021 ◽

Vol 1114 (1) ◽

pp. 012075

Author(s):

K S Sayooj ◽

M S Arun

Keyword(s):

Bone Defect ◽

Unit Cell ◽

Segmental Bone Defect ◽

Segmental Bone

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Combination of optimized tissue engineering bone implantation with heel-strike like mechanical loading to repair segmental bone defect in New Zealand rabbits

Cell and Tissue Research ◽

10.1007/s00441-021-03458-z ◽

2021 ◽

Author(s):

Cong Zhu ◽

Jianbiao Lin ◽

Huixiang Jiang ◽

Jianting Gao ◽

Mingming Gao ◽

...

Keyword(s):

Tissue Engineering ◽

New Zealand ◽

Mechanical Loading ◽

Bone Defect ◽

Heel Strike ◽

Segmental Bone Defect ◽

Segmental Bone ◽

New Zealand Rabbits

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Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

Materials ◽

10.3390/ma14133513 ◽

2021 ◽

Vol 14 (13) ◽

pp. 3513

Author(s):

Nikola Stokovic ◽

Natalia Ivanjko ◽

Drazen Maticic ◽

Frank P. Luyten ◽

Slobodan Vukicevic

Keyword(s):

Animal Models ◽

Bone Formation ◽

Bone Morphogenetic Proteins ◽

Animal Experiments ◽

Inorganic Materials ◽

New Bone Formation ◽

Segmental Bone ◽

Posterolateral Spinal Fusion ◽

Regenerative Therapies ◽

Observation Period

Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs were combined with a broad range of carriers (natural and synthetic polymers, inorganic materials, and their combinations) and tested in various models in mice, rats, rabbits, dogs, sheep, and non-human primates. In this review, we summarized bone regeneration strategies and animal models used for the initial, intermediate, and advanced evaluation of promising therapeutical solutions for new bone formation and repair. Moreover, in this review, we discuss basic aspects to be considered when planning animal experiments, including anatomical characteristics of the species used, appropriate BMP dosing, duration of the observation period, and sample size.

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