Transforaminal and systemic diffusion of an active agent from a zinc oxide eugenol-based endodontic sealer containing hydrocortisone—in an in vivo model

2020 ◽  
Vol 24 (12) ◽  
pp. 4395-4402
Author(s):  
Davy Aubeux ◽  
Anne Valot-Salengro ◽  
Gaelle Gautier ◽  
Arnaud Malet ◽  
Fabienne Pérez
Keyword(s):  
Zinc Oxide ◽  
Active Agent ◽  
In Vivo Model ◽  
Zinc Oxide Eugenol

scholarly journals Vantagens e Desvantagens do Cimento de Óxido de Zinco e Eugenol Usado para Pulpectomia em Dentes Decíduos: Revisão de Literatura

2018 ◽  
Vol 19 (5) ◽  
pp. 82
Author(s):  
F M S Costa ◽  
F Wanderley ◽  
F F F Silva ◽  
L V B Holanda ◽  
E P Beserra Neto ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Eugenol ◽  
Tooth Deciduous

O Cimento de Óxido de Zinco e Eugenol (OZE) tem sido comumente utilizado como material obturador de canais radiculares na dentição decídua, sendo o pioneiro em sua categoria, mesmo não cumprindo todos os requisitos ideais de um bom material obturador. Possui propriedades anti-inflamatórias, analgésicas e ação antimicrobiana, que reforçam a indicação de seu uso. Entretanto, sua reabsorção é mais lenta do que a de outros materiais, podendo irritar os tecidos periapicais e desviar o trajeto de erupção do dente sucessor. O objetivo deste trabalho é apontar as vantagens e desvantagens do uso de OZE para obturação de canais radiculares de dentes decíduos. Realizou-se, assim, uma revisão de literatura na base de dados PubMed, utilizando as seguintes palavras-chave combinadas entre si: “pulpectomy” “tooth deciduous”, e “zinc oxide-eugenol cement”. Foram obtidos 44 artigos entre 2006 e 2016, dos quais 11 foram selecionados, utilizando-se como critérios de inclusão casos clínicos, estudos in vivo e revisões de literatura sobre o uso de OZE para pulpectomia em dentes decíduos e como critérios de exclusão estudos que não possuíam grupo controle e que não apresentaram resultados conclusivos. Observou-se vantagens no uso do OZE como pasta endodôntica devido a sua ação analgésica e anti-inflamatória, e que, apesar das suas desvantagens, promove certa eficácia nos casos de pulpectomia quando comparada a outras pastas menos acessíveis.Palavras-chave: Pulpectomy. Tooth Deciduous. Zinc Oxide-Eugenol Cement.

Thermal Diffusion Through Amalgam and Cement Bases: Comparison of In Vitro and In Vivo Measurements

1976 ◽  
Vol 55 (3) ◽  
pp. 441-451 ◽  
Author(s):  
V.R. Tibbetts ◽  
R.J. Schnell ◽  
M.L. Swartz ◽  
R.W. Phillips
Keyword(s):  
Zinc Oxide ◽  
Calcium Hydroxide ◽  
Clinical Significance ◽  
Thermal Diffusion ◽  
Zinc Phosphate ◽  
In Vivo Measurements ◽  
Zinc Oxide Eugenol ◽  
Amalgam Restorations

Under both in vitro and in vivo conditions, bases of zinc oxide-eugenol, calcium hydroxide, and zinc phosphate cement reduced the rate of thermal diffusion through amalgam restorations. Thermal diffusion was slowest in the presence of zinc oxide-eugenol bases, followed by calcium hydroxide and zinc phosphate cement. However, the clinical significance of the differences is not known.

Inhibition of Tick-Borne Encephalitis Virus Replication with Eprosartan and Ribavirin In Vitro and In Vivo

2020 ◽  
Vol 65 (9-10) ◽  
pp. 8-12
Author(s):  
G. N. Leonova ◽  
O. S. Maistrovskaya ◽  
V. A. Lubova
Keyword(s):  
Life Expectancy ◽  
Treatment Regimen ◽  
Active Agent ◽  
Encephalitis Virus ◽  
In Vivo Model ◽  
Control Group ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

Active search for new antiviral substances is currently underway. The purpose of this work is to identify the inhibitory activity of eprosartan medication in comparison with ribavirin in vitro and in vivo in relation to tick-borne encephalitis virus. The value of the half the maximum cytotoxic concentration (CC50) for eprosartan (8.8±1.2 mg/ml) and ribavirin (1.074±0.16 mg/ml) was established. To obtain a medium effective virus-inhibiting concentration (IC50) of the medications, EIA data were used. Using nonlinear regression analysis of the percentage of antigen positive samples, IC50 values of the studied substances were obtained, which for eprosartan was 0.64±0.23 mg/ml in the treatment regimen. The selective index (SI) or chemotherapeutic index (CTI) was 13.7. The IC50 of ribavirin was 0.0067±0.0015 mg/ml, SI or CTI was 160. The suppression of viral reproduction 2.0 log TCID50 occurred in PEK cell culture under the influence of eprosartan at concentrations of 1.2–3.0 mg/ml (treatment regimen), under the influence of ribavirin — 0.2 mg/ml (prophylactic regimen) and 0.2–0.0125 mg/ml (treatment regimen). Samples with eprosartan (1.5 and 0.6 mg/ml) showed an increase in survival of mice by 50% and 20% compared with the virus control group in the in vivo model and, accordingly, an increase in average life expectancy of 5.2 and 2.1 days. Samples with ribavirin (0.05 and 0.025 mg/ml) increased the survival of mice by 60% and 40% and, accordingly, increased the life expectancy by 7.3 and 4.8 days. The data obtained allow recommending eprosartan as an active agent against tick-borne encephalitis virus along with ribavirin.

In vivo and in vitro Effects of Zinc Oxide-Eugenol (ZOE) on Biosynthesis of Cyclo-oxygenase Products in Rat Dental Pulp

1988 ◽  
Vol 67 (8) ◽  
pp. 1092-1096 ◽  
Author(s):  
S. Hashimoto ◽  
K. Uchiyama ◽  
M. Maeda ◽  
K. Ishitsuka ◽  
K. Furumoto ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Arachidonic Acid ◽  
Dental Pulp ◽  
Zinc Oxide Eugenol ◽  
In Vitro Effects ◽  
Artificial Cavity ◽  
In Vivo Effects ◽  
Made In

To determine the in vivo effects of a zinc oxide-eugenol mixture (ZOE) on the cyclo-oxygenase system in dental pulp, we used radioimmunoassay to measure the levels of prostaglandin E2 (PGE2), 13,14-dihydro-15-keto-PG (DHK-PG), thromboxane B2 (TXB2), and 6-keto-PGF1α in the dental pulp of rats. When the dental pulp was irritated by a hole made in the dentin of the mandibular incisors without use of any coolants, the levels of these cyclo-oxygenase products in the pulp were increased to, respectively, 2.8, 1.7, 10.0, and 2.6 times those in the normal pulp at six hr after treatment. In contrast, these increases in cyclo-oxygenase products disappeared immediately when the artificial cavity in the dentin was filled with ZOE (P/L; 1 g/0.25 mL), but were not altered when the cavity was filled with zinc oxide-water (ZOW, 1 g/1.5 mL). Most of the eugenol portion of ZOE was released into the pulp within two hr after the cavity was filled with ZOE. The maximal eugenol content was 35 pmol per mg of pulp. Furthermore, when the cavity was filled either with ZOE or by the addition of 10 μmol/L eugenol to the pulp homogenate, biosynthesis of 14C-6-keto-PGF1α, PGF2α, and PGE 2 from 14C-arachidonic acid in the homogenate was inhibited. These results suggest that eugenol released from ZOE in the cavity prepared in the dentin inhibited the biosynthesis of cyclo-oxygenase products during pulp irritation.

Establishment of an in vivo model for KCNJ5 dependent hyperaldosteronism

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
U Lichtenauer ◽  
PL Schmid ◽  
A Oßwald ◽  
I Renner-Müller ◽  
M Reincke ◽  
...  
Keyword(s):  
In Vivo Model

An in vivo Model for the Assessment of Acute Fibrinolytic Capacity of the Endothelium

1997 ◽  
Vol 78 (04) ◽  
pp. 1242-1248 ◽  
Author(s):  
David E Newby ◽  
Robert A Wright ◽  
Christopher A Ludlam ◽  
Keith A A Fox ◽  
Nicholas A Boon ◽  
...  
Keyword(s):  
Blood Flow ◽  
Substance P ◽  
Sodium Nitroprusside ◽  
Plasma Concentrations ◽  
In Vivo Model ◽  
Forearm Circulation ◽  
Von Willebrand ◽  
Local Release ◽  
Willebrand Factor

SummaryThe effects on blood flow and plasma fibrinolytic and coagulation parameters of intraarterial substance P, an endothelium dependent vasodilator, and sodium nitroprusside, a control endothelium independent vasodilator, were studied in the human forearm circulation. At subsystemic locally active doses, both substance P (2-8 pmol/min) and sodium nitroprusside (2-8 μg/min) caused dose-dependent vasodilatation (p <0.001 for both) without affecting plasma concentrations of PAI-1, von Willebrand factor antigen or factor VIII:C activity. Substance P caused local increases in t-PA antigen and activity (p <0.001) in the infused arm while sodium nitroprusside did not. At higher doses, substance P increased blood flow and t-PA concentrations in the noninfused arm. We conclude that brief, locally active and subsystemic infusions of intraarterial substance P cause a rapid and substantial local release of t-PA which appear to act via a flow and nitric oxide independent mechanism. This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely.

Sign in / Sign up

Export Citation Format

Share Document