scholarly journals Factors influencing the presence of Candida dubliniensis and other non-albicans species in patients with oral lichen planus: a retrospective observational study

2021 ◽  
Author(s):  
Florian Molkenthin ◽  
Moritz Hertel ◽  
Konrad Neumann ◽  
Andrea Maria Schmidt-Westhausen
Keyword(s):  
Risk Factors ◽  
Lichen Planus ◽  
Psychotropic Drugs ◽  
Oral Lichen Planus ◽  
Oral Swab ◽  
Flight Mass Spectrometry ◽  
Increased Risk ◽  
Systemic Factors ◽  
Independent Risk Factors ◽  
Oral Lichen

Abstract Objectives The epidemiologic distribution of non-albicans species in the oral cavity of oral lichen planus (OLP) patients remains uncertain. Therefore, the aim of this study was to identify factors associated with the presence of C. dubliniensis and other non-albicans species. Furthermore, independent risk factors for Candida superinfection in OLP should be identified. Material and methods Epidemiologic data and microbiological findings from 268 symptomatic OLP patients who underwent continuous oral swab culture over a 5-year period (2015–2019) were retrospectively reviewed. Candida species identification and semi-quantification were obtained by culture on CHROMagar Candida, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results C. albicans was the most frequently isolated species (72.3%), followed by C. glabrata (7.3%), C. dubliniensis (5.8%), C. krusei and C. parapsilosis (both 2.6%). The presence of C. dubliniensis was significantly associated with tobacco smoking. Other non-albicans spp. were significantly more often detected in patients using removable dentures. Increasing age and the intake of psychotropic drugs were identified as independent risk factors of Candida superinfection in OLP. Conclusion In OLP patients, certain local and systemic factors increase the risk of carrying potentially drug-resistant Candida species and the development of Candida superinfection of OLP lesions. Clinical relevance Due to the frequent detection of non-albicans species in OLP, resistance or at least reduced sensitivity to azole antifungals should be expected, especially in smokers and patients using removable dentures. In the case of oral complaints, a superinfection with Candida should be considered, whereby older patients and patients taking psychotropic drugs have an increased risk for oral infection with Candida.

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

2016 ◽  
Vol 17 (8) ◽  
pp. 692-701 ◽  
Author(s):  
Farzaneh Agha-Hosseini ◽  
Nafiseh Sheykhbahaei ◽  
Maryam-Sadat SadrZadeh-Afshar
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Potential Risk ◽  
Oral Lichen Planus ◽  
World Health ◽  
Extensive Literature ◽  
Potential Risk Factors ◽  
Oral Lichen

ABSTRACT Aim Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. Introduction World Health Organization (WHO) classifies OLP as a “potentially malignant disorder” with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored. Numerous studies have attempted to confirm the malignant transformation potential of OLP. Review results The Cochrane Controlled Trials Register, Medline and EMBASE databases, PubMed, Google Scholar, Ovid, Up To Date, BMJ Clinical Evidence, MD Consult, and Science Direct were searched for papers published between 1997 and 2015. The medical subject heading search terms were “lichen planus,” “oral lichen planus,” “erosive oral lichen planus,” “dysplasia,” “oral precancerous condition,” “oral premalignant condition,” oral cancer, oral squamous cell carcinoma (OSCC), and atrophic lichen planus. A total of 120 English language abstracts were reviewed, and 50 relevant articles identified. Because of the extensive literature on the association between OLP and SCC, we have divided the data into genetic and nongenetic factors for more accurate assessment. Conclusion In this evidence base, malignant transformation ranges from 0 to 37% with a mean of 4.59%. The highest rate of malignancy was noted in erythematosus and erosive lesions. In this way, follow-up of OLP patients could be carried out more efficiently and appropriately. Clinical significance Oral lichen planus is a premalignant lesion. All types of OLP in any site of oral mucosa must be monitored regularly. How to cite this article Agha-Hosseini F, Sheykhbahaei N, SadrZadeh-Afshar M-S. Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review. J Contemp Dent Pract 2016;17(8):692-701.

Epithelial Loss Correlated with Decreased Beta Defensins and Increased Risk of Candida Infections in Oral Lichen Planus

2015 ◽  
Vol 119 (3) ◽  
pp. e111
Author(s):  
Jeyaseelan Augustine ◽  
Chiranjit Maity ◽  
Priya Kumar ◽  
Shalini Gupta ◽  
Dipankar Ghosh ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Increased Risk ◽  
Beta Defensins ◽  
Candida Infections ◽  
Oral Lichen

Lichen Planus and Lichenoid Lesions of the Oral Cavity

1994 ◽  
Vol 103 (6) ◽  
pp. 495-497 ◽  
Author(s):  
John G. Batsakis ◽  
Karen R. Cleary ◽  
Kyung-Ja Cho
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Manifestations ◽  
Spontaneous Resolution ◽  
Increased Risk ◽  
History Of ◽  
Cutaneous Form ◽  
Oral Lichen ◽  
Chronic Course

Lichen planus is a mucocutaneous disease of unknown cause that has its principal clinical manifestations in the skin and mucosa of the oral cavity. The natural history of the cutaneous form is one of spontaneous resolution over time, while oral lichen planus pursues a much more chronic course with a low order of resolution. Oral lichen planus must be distinguished from lichenoid lesions, including lichenoid dysplasia. Malignant change in oral lichen planus is rare and is prompted by carcinogenic cofactors. There is no increased risk of development of carcinoma in cutaneous lichen planus.

Update On Oral Lichen Planus: Etiopathogenesis and Management

1998 ◽  
Vol 9 (1) ◽  
pp. 86-122 ◽  
Author(s):  
C. Scully ◽  
M. Beyli ◽  
M. C. Ferreiro ◽  
G. Ficarra ◽  
Y. Gill ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Dental Materials ◽  
Definitive Treatment ◽  
Environmental Aspects ◽  
New Associations ◽  
Increased Risk ◽  
Oral Lichen ◽  
Selection Of

Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

scholarly journals Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review

2020 ◽  
Vol 30 (4) ◽  
Author(s):  
Paria Motahari ◽  
Fatemeh Pournaghi Azar ◽  
Arefeh Rasi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lichen Planus ◽  
Vitamin D Receptor ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Increased Risk ◽  
Review Study ◽  
Oral Lichen

BACKGROUND: Oral lichen planus (OLP) is known to be a chronic inflammatory disease associated with various other systemic disorders. Studies have shown that vitamin D deficiency can be involved in the pathogenesis of lichen planus. The aim of this study was to investigate the role of vitamin D and vitamin D receptor in OLP.METHODS: In this review study, all English and Persian articles were searched by relevant keywords from the Google scholar, PubMed, science direct, Cochrane, Scopus and Sid databases until January 2020.RESULTS: From the 16 articles obtained after reviewing the abstracts, finally 14 appropriate articles were included in this study.CONCLUSION: According to the results of the studies, vitamin D deficiency may be associated with an increased risk of OLP lesions.

scholarly journals Helicobacter Pylori Infection Increases the Incidence of Erosive Oral Lichen Planus and Alters the Oral Microbiome Composition

2021 ◽  
Author(s):  
Yangheng Zhang ◽  
Shutong Li ◽  
Jingyuan Li ◽  
Ya Li ◽  
Huanjie Li ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Oral Diseases ◽  
Microbiome Composition ◽  
Carbon 14 ◽  
Increased Risk ◽  
H Pylori ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk for malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the etiological factors for OLP. Although H. pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection.Result In this study, the saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-14 urea breath test. The saliva samples were divided into the following four groups based on the H. pylori infection status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−) groups. The oral microbiome composition was significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, the incidence of erosive OLP and the salivary levels of cytokines were higher in the OLP+ group. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups.Conclusions This is the first report demonstrated that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP. The alleviation of H. pylori infection may decrease the incidence of erosive OLP.

scholarly journals Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shutong Li ◽  
Yangheng Zhang ◽  
Zongcheng Yang ◽  
Jingyuan Li ◽  
Ya Li ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Oral Diseases ◽  
Microbiome Composition ◽  
Increased Risk ◽  
H Pylori ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Although Helicobacter pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection. Result In this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on the H. pylori status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups. Conclusions This is the first report to demonstrate that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP.

scholarly journals Dental Implant Rehabilitation in Patients Suffering from Mucocutaneous Diseases: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 12 (1) ◽  
pp. 873-883 ◽  
Author(s):  
Parichehr Zarean ◽  
Paridokht Zarean ◽  
Negar Kanounisabet ◽  
Ahmad Moghareabed ◽  
Mansour Rismanchian ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Systemic Lupus Erythematosus ◽  
Lichen Planus ◽  
Lupus Erythematosus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Pemphigus Vulgaris ◽  
Systemic Lupus ◽  
Oral Lichen

Objective: Dental implantations are widely used for oral rehabilitation of edentulous patients. Despite high success rate, there are some risk factors that have been associated with failures. Oral mucocutaneous diseases are one of these risk factors for implant insertion due to the immunosuppressive therapy. There are limited studies that have dealt with the subject of dental implantology in oral mucosal disorders mainly with patients with oral lichenplanus, pemphigoid, pemphigus vulgaris, and systemic lupus erythematosus. In order to assess the result of implantations in such patients, we have reviewed the studies. Materials and Methods: We searched PubMed, Science Direct, and Cochrane databases for articles published from Jan 2000 to Dec 2017, using key search word “dental implants”, “oral lichen planus”, “pemphigoid”, “pemphigus vulgaris” and ”systemic lupus erythematosus”. Results: The random effects analysis result shows overall failure rates of 22% in patients with oral lichen planus. A systematic review revealed some failures that are not definitely related to these diseases. Conclusion: Due to the lack of adequate studies, a meta-analysis was only possible for oral lichen planus. Presently, there is no definite guideline regarding the placement of implant in patients suffering from mucocutaneous diseases; nevertheless, we should always consider that these patients are specific cases and need more attention in the first step of treatment and follow-ups. So there is a need to further clinical studies in order to evaluate more risk factors accurately and make a definitive conclusion.

Sign in / Sign up

Export Citation Format

Share Document