Sudden Death in a Neonate with Idiopathic Eosinophilic Endomyocarditis

2005 ◽  
Vol 8 (5) ◽  
pp. 587-592 ◽  
Author(s):  
Henry F. Krous ◽  
Elisabeth Haas ◽  
Amy E. Chadwick ◽  
Glenn N. Wagner

A 26-day-old male infant who had been fussy and feeding poorly for a period of several hours died suddenly despite efforts at resuscitation. Postmortem examination revealed eosinophilic endomyocarditis unassociated with disease in other organs. The etiology remained unexplained after review of the medical and family histories and circumstances of death, extensive light and immunofluorescence microscopies, and microbiological, metabolic, and toxicologic testing. This appears to be the youngest reported case of eosinophilic endomyocarditis, a disorder that typically occurs in middle-age males and is often associated with benign or malignant hypereosinophilic conditions. The medical literature is reviewed.

2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Samuel Anu Olowookere ◽  
Adegboyega Adeleke Abiodun ◽  
Joseph Gbenga Omole ◽  
Akinwumi Oluwole Komolafe ◽  
Akintunde Julius Olowookere ◽  
...  

BACKGROUND: Postmortem examination is necessary to diagnose the cause of sudden death, and family caregivers are expected to consent to this examination. This study assessed knowledge, attitude, practices and willingness of family caregivers to consent to postmortem examination of their relative if they die suddenly in a Nigerian tertiary hospital.METHODS: Descriptive cross-sectional study of family caregivers of our patients that completed an interviewer administered semistructured questionnaire assessing their knowledge, attitude, practices and willingness to consent to postmortem examination of their relative if they die suddenly. Data were analyzed using descriptive and inferential statistics.RESULTS: A total of 224 caregivers were interviewed. The mean age (SD) was 34.95 (11.74), ranging 22-75 years. They were parents (32.6%), siblings (37.9%), spouses (11.2%) and other relatives (18.3%). Only 17% had adequate knowledge, 44.6% positive attitude and 11.2% good practices to postmortem examination of sudden death. The majority (75.9%) would consent to postmortem examination of their relatives if they die suddenly. Sociodemographic variables associated with willingness to consent to postmortem examination after relative’s sudden death include being male (AOR 3.61; 95%CI 3.09-8.92; p=0.001), having tertiary education (AOR 4.83; 95%CI 1.01-8.29; p=0.034), Christianity (AOR 2.59; 95%CI 1.25-5.35; p=0.010) and skilled worker (AOR 1.43; 95%CI 1.33-3.80; p=0.020).CONCLUSION: Some family caregivers would not consent to postmortem examination of their relatives when they die suddenly. Sensitization programs targeting family caregivers are necessary to increase knowledge and enhance prevention of sudden death as well as improve willingness to consent to postmortem examination when their relatives die suddenly.


2005 ◽  
Vol 91 (1) ◽  
pp. 90-92 ◽  
Author(s):  
Roberto Buzzoni ◽  
Silvia Della Torre ◽  
Diego Cortinovis ◽  
Laura Catena

Synchronous multicentric osteosarcoma is a rare entity with fewer than 100 well documented cases in the medical literature. The disease usually progresses rapidly in young patients and slightly slower in adults. We present a case of synchronous multicentric osteosarcoma with some peculiarities in a 73-year-old woman. The diagnosis was made after postmortem examination, which underlines the importance of this procedure. This case report is accompanied by a review of the literature.


1991 ◽  
Vol 21 (4) ◽  
pp. 393-400 ◽  
Author(s):  
Antonio Palacios ◽  
Mary Ann Adler Cohen ◽  
Ronald Cobbs

Apathetic hyperthyroidism was first described in the medical literature by Lahey in 1931. It is a form of hyperthyroidism found principally in the elderly population. In this disorder the usual hyperkinetic presentation of thyrotoxicosis is replaced by apathy and inactivity, often leading to an erroneous psychiatric diagnosis. Although there is a paucity of literature on apathetic hyperthyroidism, it has been described in the elderly and as an extremely rare complication of hyperthyroid disorder in children. It was described only rarely in middle age. The following case highlights the diagnostic and therapeutic dilemmas encountered in a middle-aged patient who presented with dementia and apathetic hyperthyroidism.


2019 ◽  
Vol 8 (1) ◽  
pp. 54-56
Author(s):  
Faiza Kamran Ali ◽  
Feriha Fatima Khidri ◽  
Kamran Ali Shahani ◽  
Rafia Shah

Amniotic fluid embolism (AFE) is a rare presentation in obstetric emergencies that carries great risk for the life of both mother and fetus. It is usually characterized by sudden cardiovascular collapse, respiratory distress and disseminated intravascular coagulation. Here we present a case of sudden death of a pregnant woman due to suspected AFE. We also present a rare finding of natal teeth in her deceased baby, which along with reported AFE in the mother, is an unlikely event in the medical literature.


2017 ◽  
Vol 29 (4) ◽  
pp. 457-464 ◽  
Author(s):  
Josepha DeLay

Postmortem lesions and cause of death were evaluated retrospectively for 963 horses examined as part of the Ontario Racing Commission Death Registry over a 13-y period. The Death Registry was established in 2003 to identify factors leading to death or euthanasia of racehorses in this Canadian province. Postmortem examination was carried out on 56% of horses reported to the Death Registry and included Standardbred, Thoroughbred, and American Quarter Horses. Musculoskeletal injury was the most common reason for death associated with racing or training among all racehorses and involved 68% of horses. A history of sudden death during or immediately following exercise was described for 31% of racing- or training-associated deaths, and in 16% of all horses in the study. Sudden death occurred in horses of all breeds, and our report describes lesions associated with sudden death in a series of Standardbreds. The cause of death in these cases was most frequently attributed to cardiopulmonary lesions. The cause of death was undetermined in 20% of sudden death cases, and it is speculated that cardiac arrhythmia may have contributed to these deaths. Injection-associated death was documented in 4% of the study population. Lesions among horses whose death was not associated with exercise were similar to those in other equine populations, and lesions involving the gastrointestinal system were most common. Standardization of pathology reporting of pulmonary and other lesions in racehorse postmortem cases would allow direct comparison of results among racehorse populations.


PEDIATRICS ◽  
1963 ◽  
Vol 32 (2) ◽  
pp. 288-290
Author(s):  
HERMAN W. HYATT

Since it appears that no case of lymphatic transfer of smallpox vaccine to new areas with resultant primary takes or of excessive hair growth around the periphery of a recently healed smallpox scar has been described in the medical literature, it seems important to report one infant with the former, and another with the latter, condition. Case 1 F.S., a 3-week-old white male infant, received a smallpox vaccination on the right deltoid area, June 3, 1956 at Kern County Health Department, Bakersfield, California. On June 15, an enlarged lymph node (about 1.5 cm in diameter) appeared in the right axilla. Although somewhat tender on June 15 and 16, the swollen node was barely palpable on June 17. On June 16, an elevated erythematous "ridge" extended from the right deltoid vaccination site to the elbow. On June 17, the erythematous area had extended to the dorsum of the hand, about 1 cm below the wrist. Immediately below the termination of the "ridge" a small yellow vesicle had formed, after which the entire erythematous area disappeared. Subsequently, an elevated erythematous area extended from the vesicle to the end of the distal phalanx of the third right finger. On June 19, a yellow vesicle formed on the indicated finger immediately below the termination of the erythematous area. Shortly after the formation of the second vesicle, the erythematous "ridge" spontaneously disappeared. The vesicles underwent desiccation, umbilication, and scab formation. The scabs thereafter separated, leaving the typical pitted smallpox scar. (Except for the tiny needle pricks related to the original inoculation, there was no change in the deltoid vaccination site.)


1994 ◽  
Vol 34 (1) ◽  
pp. 80-82 ◽  
Author(s):  
M A Elfawal

Association between systemic lupus erythematosus and coronary atherosclerosis has been reported only rarely in the medical literature. Sudden ischaemic cardiac death in such cases is an uncommon terminal event, particularly in young patients. The severity of coronary atherosclerosis in these cases may be similar to those seen in the classic coronary disease. A case of a 22-year-old female systemic lupus patient is presented in whom sudden death was found at autopsy to be due to extensive coronary atherosclerosis.


2018 ◽  
Vol 30 (5) ◽  
pp. 747-751 ◽  
Author(s):  
John M. Adaska ◽  
Guillermo Rimoldi ◽  
Patricia C. Blanchard ◽  
John Champagne ◽  
Robert H. Poppenga ◽  
...  

Over a 1-y period, a California calf-raising operation experienced 4 separate episodes of sudden death in 4–6-mo-old steers. Each episode occurred in 1–3 contiguous pens on 1 of 3 properties owned by the operation, but eventually all 3 properties were involved. In each episode, animals appeared normal at the evening feeding but at the subsequent morning feeding were found dead or dying. Remaining live calves had a stiff gait and were often dribbling urine, but did not show respiratory signs until they were down and agonal. At postmortem examination, calves consistently had moderate-to-large numbers of ecchymotic and suffusive hemorrhages on the epicardial surface and moderate-to-large amounts of fluid in the pericardial sac. Pulmonary edema and/or moderate amounts of watery fluid in the thoracic and abdominal cavities were present in a smaller percentage. On histologic examination, the myocardium had variable myofiber degeneration characterized by hypereosinophilia and fragmentation with mild interstitial infiltrates. Testing of heart and liver samples for monensin found levels lower than in previous cases of monensin toxicity. Rumen content was negative for oleandrin and grayanotoxins. Sodium monofluoroacetate (trade name: 1080) was consistently detected at ⩾10 ppb in kidney and liver, and was concluded to be the cause of the intoxication.


2017 ◽  
Vol 29 (4) ◽  
pp. 442-449 ◽  
Author(s):  
Santiago S. Diab ◽  
Robert Poppenga ◽  
Francisco A. Uzal

In racehorses, sudden death (SD) associated with exercise poses a serious risk to jockeys and adversely affects racehorse welfare and the public perception of horse racing. In a majority of cases of exercise-associated sudden death (EASD), there are no gross lesions to explain the cause of death, and an examination of the cardiovascular system and a toxicologic screen are warranted. Cases of EASD without gross lesions are often presumed to be sudden cardiac deaths (SCD). We describe an equine SD autopsy protocol, with emphasis on histologic examination of the heart (“cardiac histology protocol”) and a description of the toxicologic screen performed in racehorses in California. By consistently utilizing this standardized autopsy and cardiac histology protocol, the results and conclusions from postmortem examinations will be easier to compare within and across institutions over time. The generation of consistent, reliable, and comparable multi-institutional data is essential to improving the understanding of the cause(s) and pathogenesis of equine SD, including EASD and SCD.


2009 ◽  
pp. 131-139
Author(s):  
Walter E. Finkbeiner ◽  
Philip C. Ursell ◽  
Richard L. Davis ◽  
Andrew J. Connolly

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