Genetically predicted serum uric acid levels and the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study

Abstract Background To investigate the causal association between serum 25-hydroxyvitamin D (25OHD), calcium (Ca), and parathyroid hormone (PTH) levels and the risk of coronary artery disease (CAD) in patients with diabetes using a Mendelian randomization approach. Methods Genetic signatures associated with serum 25OHD, Ca, and PTH levels were extracted from recently published genome-wide association study (GWAS), including 79,366, 39,400, 29,155 individuals, respectively. Genetic association estimates for CAD in patients with diabetes were obtained from a GWAS of 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The inverse-variance-weighted method was employed for the primary analysis, and other robust methods were applied for sensitivity analyses. Results Six, seven and five single nucleotide polymorphisms were identified as instrumental variables for serum 25OHD, Ca and PTH levels, respectively. There was no significant association between genetically predicted serum 25OHD levels and the risk of CAD in patients with diabetes (odds ratio (OR) = 1.04, 95% confidence interval (CI): 0.58 - 1.87, P = 0.888). Similarly, genetically predicted serum Ca (OR = 1.83, 95% CI: 0.62 – 5.35, P = 0.273) and PTH levels (OR = 1.27, 95% CI: 0.67 – 2.44, P = 0.464) were not significantly associated with the risk of CAD in patients with diabetes. These findings were robust in sensitivity analyses. Conclusions/interpretation Serum 25OHD, Ca and PTH levels may not be causally associated with the risk of CAD in patients with diabetes.

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Abstract P049: Serum Uric Acid Levels Are Associated With Non-Calcified Coronary Plaque Independent of Traditional Cardiovascular Risk Factors in Patients With Psoriasis

Circulation ◽

10.1161/circ.137.suppl_1.p049 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Youssef A Elnabawi ◽

Amit K Dey ◽

Agastya D Belur ◽

Aditya Goyal ◽

Jacob W Groenendyk ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Coronary Plaque ◽

Chronic Inflammatory Disease ◽

Human Model ◽

Plaque Burden ◽

Artery Disease

Introduction: Serum uric acid (sUA), a known inflammosome-inducer, is associated with prospective risk of coronary artery disease in a dose-dependent fashion. Psoriasis (PSO), a chronic inflammatory disease associated with elevated burden of systemic inflammation and subclinical coronary artery disease, provides a reliable human model to study how sUA may relate to non-calcified coronary plaque burden (NCB) measured by computed coronary tomography angiography (CCTA). Hypothesis: We hypothesized that sUA would directly associate with NCB beyond traditional cardiovascular (CV) risk factors. Methods: 103 consecutive PSO patients and 47 healthy volunteers (HV) underwent CCTA (320 detector row, Toshiba) for coronary plaque burden quantification using QAngio (Medis). PSO severity was assessed by Psoriasis Area Severity Score (PASI) and divided into severe PSO (PASI>10) and mild-moderate PSO (PASI<10). All patients had fasting blood draws for the measurement of sUA at a certified clinical lab. Results: PSO patients were older than HV and had a higher CV risk by Framingham risk score (FRS) (Table 1). We observed a significant trend towards increase in sUA among severe PSO, mild-moderate PSO, and HV groups (mean 6.4, 5.9, 5.4 respectively, p=0.02 for trend). A positive association was observed between sUA and NCB, which was stronger in severe PSO after adjustment for traditional CV risk, alcohol, statins, and systemic/biologic PSO treatment (Severe PSO: β=0.27, p<0.001; Mild-moderate PSO: β=0.18, p=0.03), not significant in HV (β=0.18, p=0.12). Conclusions: sUA is independently associated with NCB in states of chronic inflammation such as PSO, and as such, may potentially serve as a biomarker for subclinical coronary atherosclerosis. However, larger prospective studies of CV outcomes in chronic inflammatory diseases are needed to confirm these results.

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Gender Differences in the Role of Serum Uric Acid for Predicting Cardiovascular Events in Patients with Coronary Artery Disease

Korean Circulation Journal ◽

10.4070/kcj.2007.37.5.196 ◽

2007 ◽

Vol 37 (5) ◽

pp. 196 ◽

Cited By ~ 3

Author(s):

Dae-Woo Hyun ◽

Ki-Hong Kim ◽

Hyun-Ju Yoon ◽

Taek-Geun Kwon ◽

Ki-Young Kim ◽

...

Keyword(s):

Coronary Artery Disease ◽

Gender Differences ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Cardiovascular Events ◽

Artery Disease

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Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease

Clinical Rheumatology ◽

10.1007/s10067-015-2878-1 ◽

2015 ◽

Vol 34 (9) ◽

pp. 1605-1611 ◽

Cited By ~ 11

Author(s):

Xiao-Min Dai ◽

Lei Wei ◽

Li-Li Ma ◽

Hui-Yong Chen ◽

Zhuo-Jun Zhang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Serum Uric Acid ◽

Early Onset ◽

Risk Profile ◽

Chinese Patients ◽

Cardiovascular Risk Profile ◽

Artery Disease

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Sex differences in the association between serum uric acid and cardiac mortality in Asian patients with established coronary artery disease: A revisit of the ET-CHD registry in Taiwan, 1997–2003

Journal of Cardiology ◽

10.1016/j.jjcc.2016.02.008 ◽

2016 ◽

Vol 68 (5) ◽

pp. 461 ◽

Cited By ~ 2

Author(s):

Yi-Hwei Li ◽

Gen-Min Lin

Keyword(s):

Coronary Artery Disease ◽

Sex Differences ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Cardiac Mortality ◽

Established Coronary Artery Disease ◽

Asian Patients ◽

Artery Disease

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A study of angiographic severity in patients with coronary artery disease and hyperuricemia

Asian Journal of Medical Sciences ◽

10.3126/ajms.v7i2.12717 ◽

2015 ◽

Vol 7 (2) ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Subhraprakash Pramanik ◽

Koushik Mondal ◽

Arpan Kumar Dey ◽

Pijush Kanti Mandal ◽

Shovan Kumar Das ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

P Value ◽

Gensini Score ◽

Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

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