Time-Dependent Changes in the Serum Levels of Neurobiochemical Factors After Acute Methadone Overdose in Adolescent Male Rat

2020 ◽  
Author(s):  
Leila Ahmad-Molaei ◽  
Mahsa Pourhamzeh ◽  
Reza Ahadi ◽  
Fariba Khodagholi ◽  
Hossein Hassanian-Moghaddam ◽  
...  
Keyword(s):  
Serum Levels ◽  
Time Dependent ◽  
Adolescent Male ◽  
Male Rat ◽  
Methadone Overdose

HYPOTHALAMIC-PITUITARY-TESTICULAR SYSTEM AND ADRENOCORTICAL FUNCTION

1976 ◽  
Vol 81 (1) ◽  
pp. 198-207 ◽  
Author(s):  
H. L. Verjans ◽  
K. B. Eik-Nes
Keyword(s):  
Adrenal Gland ◽  
Blood Serum ◽  
Adult Male ◽  
Serum Levels ◽  
Male Rats ◽  
Intramuscular Administration ◽  
Adrenocortical Function ◽  
Male Rat ◽  
Pituitary Secretion ◽  
Slight Elevation

ABSTRACT Effect of intramuscular administration of ACTH or dexamethasone on blood serum levels of testosterone, LH and FSH was examined in intact and castrated, adult, male rats. Six IU ACTH or 1 mg dexamethasone were given daily for 7 days. Corticotrophin treatment had no influence on circulating testosterone, LH and FSH in intact or castrated male rats. Dexamethasone administration resulted in a slight elevation of serum FSH in intact animals but not in castrates. LH and testosterone remained normal in both intact and castrated animals injected with dexamethasone. Under our conditions of study the secretions from the adrenal gland appear to be insignificant for the regulation of pituitary secretion of gonadotrophins in the male rat.

Time-dependent sensitization of antipsychotic effect in adolescent male and female rats

2017 ◽  
Vol 328 ◽  
pp. 186-194 ◽  
Author(s):  
Xiaojing Ding ◽  
Xiaonan Li ◽  
Qing Shu ◽  
Ruiyong Wu ◽  
Gang Hu ◽  
...  
Keyword(s):  
Time Dependent ◽  
Female Rats ◽  
Adolescent Male ◽  
Male And Female ◽  
Antipsychotic Effect ◽  
Male And Female Rats

scholarly journals Investigation Into Effect Of Crude Mixture Of Abrus Precatorius Seed On Hypothalamopituitary Gonadal Axis And Development Of Antifertility In Male Rats

1970 ◽  
Vol 36 (1) ◽  
pp. 103-109 ◽  
Author(s):  
S Talukder ◽  
MA Hossain ◽  
S Sarker ◽  
MAH Khan
Keyword(s):  
Negative Impact ◽  
Sperm Count ◽  
Sharp Decrease ◽  
Serum Levels ◽  
Serum Biochemistry ◽  
Male Rats ◽  
Male Rat ◽  
Control Group ◽  
Abrus Precatorius ◽  
Crude Mixture

To evaluate the antifertility effect of crude mixture of A. precatorius seeds at the dose level of 50 mg/kg body weight in adult male rats, after oral administration to male rats for 40 days, the rats were sacrificed and hormonal profiles, serum biochemistry, sperm count and histological changes were recorded. A sharp decrease in the serum levels of testosterone (0.70 ± 0.17 ng/ml), FSH (0.70 ± 0.22 lU/L), and LH (0.87 ± 0.35 IU/L) was detected compared to control (FSH, LH and testosterone levels 0.93 ± 0.15 ng/ml, 0.76 ± 0.28 IU/L, 1.44 ± .011 IU/L, respectively). A significant reduction of epididymal sperm count (2.34 million/mL) was noted in treated rats as compared to control group (7.87 million/mL). Histology of testes showed marked atrophy of the testes, which was characterized by disruption of the seminiferous epithelium and atrophy of the Leydig cells. Crude mixture of A. precatorius seed has a negative impact on male reproductive functions. It might be suggested that crude mixture of A. precatorius seeds might have antifertility property for male rats.   Keywords: Abrus precatorius; antifertility; male rat; testosterone. DOI: http://dx.doi.org/10.3329/bjar.v36i1.9234 BJAR 2011; 36(1): 103-109

High-dose testosterone enanthate supplementation boosts oxidative stress, but exerts little effect on the antioxidant barrier in sedentary adolescent male rat liver

2017 ◽  
Vol 69 (4) ◽  
pp. 673-678 ◽  
Author(s):  
Ewa Sadowska-Krępa ◽  
Barbara Kłapcińska ◽  
Sławomir Jagsz ◽  
Anna Nowara ◽  
Izabela Szołtysek-Bołdys ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Adolescent Male ◽  
Male Rat ◽  
High Dose ◽  
Testosterone Enanthate

scholarly journals Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles

2018 ◽  
Vol 245 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Mohammed Hassan Gaballah ◽  
Tetsuya Horita ◽  
Masataka Takamiya ◽  
Keisuke Yokoji ◽  
Mamiko Fukuta ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Skeletal Muscles ◽  
Serum Levels ◽  
Time Dependent ◽  
Incised Wound

scholarly journals Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

2017 ◽  
Vol 118 (11) ◽  
pp. 930-941 ◽  
Author(s):  
Keyth Sulamitta L. Guimarães ◽  
Emmanuel Veríssimo de Araújo ◽  
Jailane Souza Aquino ◽  
Danilo Assis Gadelha ◽  
Camille Moura Balarini ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Biochemical Parameters ◽  
Low Frequency ◽  
Hdl Cholesterol ◽  
Wistar Rat ◽  
Serum Levels ◽  
Male Offspring ◽  
Male Rat ◽  
Standard Diet ◽  
Predisposing Factor

AbstractThe present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4·0-fold), TAG (2·0-fold), VLDL+LDL (7·7-fold) and reduced HDL-cholesterol (2·4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P<0·05) and VLDL+LDL (P<0·05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P=0·0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.

Time-dependent effects of oestradiol and progesterone on hypothalamic catecholamine turnover in ovariectomized rats

1985 ◽  
Vol 106 (3) ◽  
pp. 303-309 ◽  
Author(s):  
C. Hiemke ◽  
D. Bruder ◽  
M. C. Michel ◽  
R. Ghraf
Keyword(s):  
Turnover Rate ◽  
Brain Area ◽  
Serum Levels ◽  
Time Dependent ◽  
Ovariectomized Rats ◽  
Dopamine Turnover ◽  
Turnover Rates ◽  
Noradrenaline Turnover ◽  
Time Element ◽  
Increased Sensitivity

ABSTRACT Long-term ovariectomized rats received a single injection of 20 μg oestradiol benzoate (OB) which reduced the serum levels of LH for at least 3 days. The inhibitory effects were accompanied by time-dependent alterations of noradrenaline and dopamine turnover rates in the mediobasal hypothalamus (MBH) and the preoptic-anterior hypothalamic brain area (POAH). Oestradiol markedly interfered with the time-dependent variations of noradrenaline and dopamine turnover seen in the MBH of untreated ovariectomized animals during daylight hours. In the POAH the turnover rate of noradrenaline decreased 2 days after priming with OB and then increased in the afternoon of day 3. The increase of noradrenaline turnover in the POAH was accompanied by a low afternoon turnover rate of dopamine in the M BH and by an increased sensitivity of the LH secretory system to progesterone. Dopamine and noradrenaline turnover involve a time element. While the negative feedback actions of oestradiol do not seem to be associated with changes in dopamine or noradrenaline turnover, the results support the view that the induction of LH afternoon surges depends upon an increase of stimulatory noradrenergic inputs to the POAH and a decrease of inhibitory dopaminergic inputs in the MBH. J. Endocr. (1985) 106, 303–309

scholarly journals Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

1998 ◽  
Vol 159 (1) ◽  
pp. 79-83 ◽  
Author(s):  
N LaPaglia ◽  
J Steiner ◽  
L Kirsteins ◽  
M Emanuele ◽  
N Emanuele
Keyword(s):  
Growth Hormone ◽  
Nutritional Status ◽  
Serum Levels ◽  
Male Rat ◽  
Igf I ◽  
Adult Male Rat ◽  
Steady State Levels ◽  
Hormonal System ◽  
Neuroendocrine Responses ◽  
Serum Gh

Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion within the GRF-GH-IGF axis in the adult male rat during almost 3 days of fasting. Serum levels of GH and IGF-I were drastically suppressed by fasting. Daily leptin administration was able to fully prevent the fasting-induced fall in serum GH. Leptin failed to restore IGF-I to control levels, however, suggesting possible GH resistance. Fasting caused an insignificant increase in GH mRNA, while leptin injections significantly increased steady-state levels of this message. The GRF receptor (GRFr) message was not altered with fasting or leptin treatment. Leptin also exhibited effects at the hypothalamic level. Fasting induced a sharp fall in GRF mRNA expression and leptin injections partially prevented this fall. However, there were no observed changes in the hypothalamic GRF content. These results provide evidence that leptin may function as a neuromodulator of the GRF-GH-IGF axis communicating to this hormonal system the nutritional status of the animal.

scholarly journals Hemorrhagic Transformation and Microvascular Integrity during Focal Cerebral Ischemia/Reperfusion

1996 ◽  
Vol 16 (6) ◽  
pp. 1373-1378 ◽  
Author(s):  
Gerhard F. Hamann ◽  
Yasushi Okada ◽  
Gregory J. del Zoppo
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Hemorrhagic Transformation ◽  
Artery Occlusion ◽  
Time Dependent ◽  
Adolescent Male ◽  
Blood Components ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Artery Occlusion

Hemorrhagic transformation after cerebral ischemia is a well known clinical concern. The frequency of intact basal lamina (BL), identified by laminin antigen, in hemorrhagic and nonhemorrhagic zones after middle cerebral artery occlusion (MCA:O) and 3-h MCA:O with reperfusion in adolescent male baboons was assessed. Parenchymal hemoglobin was not detected prior to 24-h reperfusion. A significant decrease in the density of laminin (BL) in hemorrhagic zones (6.2 ± 2.4) compared with nonhemorrhagic ischemic zones (10.5 ± 2.4) (p < 0.05) and nonischemic basal ganglia (17.0 ± 2.7) (p < 0.01) was observed. Time-dependent changes in BL integrity appear linked to the extravasation of blood components.

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