scholarly journals Decline of coronary heart disease mortality is strongly effected by changing patterns of underlying causes of death: an analysis of mortality data from 27 countries of the WHO European region 2000 and 2013

2020 ◽  
Author(s):  
Susanne Stolpe ◽  
Bernd Kowall ◽  
Andreas Stang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cause Of Death ◽  
Western Europe ◽  
Causes Of Death ◽  
Total Mortality ◽  
Coronary Heart Disease Mortality ◽  
Mortality Rates ◽  
Mortality Data ◽  
Underlying Causes

AbstractMortality rates for coronary heart disease (CHD) experience a longstanding decline, attributed to progress in prevention, diagnostics and therapy. However, CHD mortality rates vary between countries. To estimate whether national patterns of causes of death impact CHD mortality, data from the WHO “European detailed mortality database” for 2000 and 2013 for populations aged ≥ 80 years was analyzed. We extracted mortality rates for total mortality, cardiovascular diseases, neoplasms, dementia and ill-defined causes. We calculated proportions of selected causes of death among all deaths, and proportions of selected cardiovascular causes among cardiovascular deaths. CHD mortality rates were recalculated after re-coding ill-defined causes of death. Association between CHD mortality rates and proportions of CHD deaths was estimated by population-weighted linear regression. National patterns of causes of death were divers. In 2000, CHD was assigned as cause of death in 13–53% of all cardiovascular deaths. Until 2013, this proportion changed between − 65% (Czech Republic) and + 57% (Georgia). Dementia was increasingly assigned as underlying cause of death in Western Europe, but rarely in eastern European countries. Ill-defined causes accounted for between < 1% and 53% of all cardiovascular deaths. CHD mortality rates were closely linked to a countries’ proportion of cardiovascular deaths assigned to CHD (R2 = 0.95 for 2000 and 0.99 for 2013). We show that CHD mortality is considerably influenced by national particularities in certifying death. Changes in CHD mortality rates reflect changes in certifying competing underlying causes of death. This must be accounted for when discussing reasons for the CHD mortality decline.

scholarly journals ADJUDICATION PILOT STUDY OF CAUSE OF DEATH IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S926-S926
Author(s):  
Habibatou Diallo ◽  
Joanne Murabito ◽  
Anne B Newman ◽  
Thomas T Perls ◽  
Diane Ives ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pilot Study ◽  
Cause Of Death ◽  
Medical Records ◽  
Causes Of Death ◽  
Death Certificate ◽  
Family Study ◽  
Underlying Causes ◽  
Long Life

Abstract Background: Death certificate inaccuracy increases at older ages. The Long Life Family Study (LLFS) utilizes a physician adjudication committee to review the death certificate, medical records and a family narrative about cause of death. We report here the adjudication process and the prevalent underlying causes of death for a subsample of those who have died so far. Methods: We first describe the adjudication process. There were ~1,250 deaths in LLFS. We report underlying causes of death for a subset of proband generation subjects enrolled and evaluated by two LLFS study centers. Results: As of May 2019, we have adjudicated 190 deaths (98 male, 92 female) . Mean age 95 years (range 81-105 years). Top 5 causes of death for men: cancer (13%), coronary heart disease (CHD, 13%), dementia (13%), "other" (11%) and "unknown" (9%) and for women: dementia (21%), valvular heart disease (14%), coronary heart disease (12%), unknown (12%) and other (9%). Rate of death due to dementia was greater in women compared to men (CHI2 =7.33, p=0.006). Conclusions: In this pilot study, a significantly greater proportion of women died due to dementia compared to men. At least some portion of this difference may be due to the observation that women are known to survive chronic aging-related diseases more than men and thus have a greater opportunity to die from dementia at advanced ages. An additional cause to consider includes clinicians’ gender bias in ascribing diagnoses in the medical records that were relied upon as part of the adjudication process.

scholarly journals Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e035767
Author(s):  
Christopher M DeGiorgio ◽  
Ashley Curtis ◽  
Armen Carapetian ◽  
Dominic Hovsepian ◽  
Anusha Krishnadasan ◽  
...  
Keyword(s):  
Heart Disease ◽  
Vascular Dementia ◽  
Ischaemic Heart Disease ◽  
Cause Of Death ◽  
Causes Of Death ◽  
Mortality Rates ◽  
Population Based ◽  
All Cause Mortality ◽  
The Usa ◽  
Underlying Causes

IntroductionEpilepsy mortality rates are rising. It is unknown whether rates are rising due to an increase in epilepsy prevalence, changes in epilepsy causes of death, increase in the lethality or epilepsy or failures of treatment. To address these questions, we compare epilepsy mortality rates in the USA with all-cause and all-neurological mortality for the years 1999 to 2017.ObjectivesTo determine changes in US epilepsy mortality rates versus all-cause mortality, and to evaluate changes in the leading causes of death in people with epilepsy.DesignRetrospective population-based multiple cause-of-death study.Primary outcomeChange in age-adjusted epilepsy mortality rates compared with mortality rates for all-cause and all-neurological mortality.Secondary outcomeChanges in the leading causes of death in epilepsy.ResultsFrom 1999 to 2017, epilepsy mortality rates in the USA increased 98.8%, from 5.83 per million in 1999 to 11.59 per million (95% CI 88.2%–110.0%), while all-cause mortality declined 16.4% from 8756.34 per million to 7319.17 per million (95% CI 16.3% to 16.6%). For the same period, all-neurological mortality increased 80.8% from 309.21 to 558.97 per million (95% CI 79.4%–82.1%). The proportion of people with epilepsy who died due to neoplasms, vascular dementia and Alzheimer’s increased by 52.3%, 210.1% and 216.8%, respectively. During the same period, the proportion who died due to epilepsy declined 27.1%, while ischaemic heart disease as a cause of death fell 42.6% (p<0.001).ConclusionsEpilepsy mortality rates in the USA increased significantly from 1999 to 2017. Likely causes include increases in all-neurological mortality, increased epilepsy prevalence and changes in the underlying causes of death in epilepsy, led by increases in vascular dementia and Alzheimer’s. An important finding is that ischaemic heart disease and epilepsy itself are declining as underlying causes of death in people with epilepsy.

scholarly journals Contribution of Climate and Air Pollution to Variation in Coronary Heart Disease Mortality Rates in England

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32787 ◽  
Author(s):  
Peter Scarborough ◽  
Steven Allender ◽  
Mike Rayner ◽  
Michael Goldacre
Keyword(s):  
Air Pollution ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Mortality ◽  
Mortality Rates ◽  
Disease Mortality

Prediction of Cancer and Coronary Heart Disease Mortality by Means of a Personality Inventory: Results of a 15-Year Follow-up Study

1993 ◽  
Vol 72 (2) ◽  
pp. 499-516 ◽  
Author(s):  
H. J. Eysenck
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cause Of Death ◽  
Personality Type ◽  
Coronary Heart Disease Mortality ◽  
Follow Up Study ◽  
Disease Mortality ◽  
Two Samples ◽  
Healthy Persons

This paper reports on the 1982–1986 follow-up of two samples of healthy persons first studied in 1972 and followed up in 1982 when mortality and cause of death were established ( N = 2,146). Both were related to stress and personality type according to clearly elaborated theories, and results were very much in accordance with theory. The second follow-up was instigated to answer criticisms of the first study and to test whether results would still support the theories involved. The data support the previous results strongly and show that psychosocial data can predict with considerable accuracy mortality and cause of death over 14 years ahead.

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