Caffeic acid inhibits in vitro rooting in mung bean [Vigna radiata (L.) Wilczek] hypocotyls by inducing oxidative stress

2008 ◽  
Vol 57 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Harminder Pal Singh ◽  
Shalinder Kaur ◽  
Daizy R. Batish ◽  
Ravinder Kumar Kohli
2019 ◽  
Vol 7 (12) ◽  
pp. 4063-4075
Author(s):  
Dandan Liu ◽  
Xiao Guan ◽  
Kai Huang ◽  
Sen Li ◽  
Jing Liu ◽  
...  

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 746
Author(s):  
Garyfallia Kapravelou ◽  
Rosario Martínez ◽  
Gloria Perazzoli ◽  
Cristina Sánchez González ◽  
Juan Llopis ◽  
...  

The use of legumes as functional foods has gained increasing attention for the prevention and treatment of the so called non-communicable diseases that are highly prevalent worldwide. In this regard, biotechnological approaches for the enhancement of legumes’ nutritional and functional value have been extensively employed. In the present study, the process of germination increased several parameters of mung bean (Vigna radiata L.) functionality, including extract yield, total phenolic content and in vitro antioxidant capacity. In addition, 3-day-germinated mung bean proved to be an interesting source of dietary essential minerals and exhibited a greater variety of polyphenolic compounds compared to raw mung bean. These properties resulted in enhanced cytoprotective features of the 3-day mung bean extracts against radical oxygen species in human colorectal (HT29) and monocyte (U937) cell lines. Moreover, the antiproliferative effects were tested in different colon cancer cell lines, T84 and drug-resistant HCT-18, as well as in a non-tumor colon CCD-18 line. Altogether, our results demonstrate that the germination process improves the mung bean’s nutritional value and its potential as a functional food.


2009 ◽  
Vol 407 (21) ◽  
pp. 5543-5547 ◽  
Author(s):  
Ved Parkash Sharma ◽  
Harminder Pal Singh ◽  
Ravinder Kumar Kohli ◽  
Daizy Rani Batish

2008 ◽  
Vol 86 (5) ◽  
pp. 279-287 ◽  
Author(s):  
Ting Wang ◽  
Lixiang Chen ◽  
Weimin Wu ◽  
Yuan Long ◽  
Rui Wang

Oxidative stress is considered to be a major cause of cellular injuries in a variety of chronic health problems, such as carcinogenesis and neurodegenerative disorders. Caffeic acid phenethyl ester (CAPE), derived from the propolis of honeybee hives, possesses a variety of biological and pharmacological properties including antioxidant and anticancer activity. In the present study, we focused on the diverse antioxidative functionalities of CAPE and its related polyphenolic acid esters on cellular macromolecules in vitro. The effects on human erythrocyte membrane ghost lipid peroxidation, plasmid pBR322 DNA, and protein damage initiated by the water-soluble initiator 2,2′-azobis(2-amidinopropane) hydrochloride (AAPH) and hydrogen peroxide (H2O2) were monitored by formation of hydroperoxides and by DNA nicking assay, single-cell alkaline electrophoresis, and SDS-polyacrylamide gel electrophoresis. Our results showed that CAPE and its related polyphenolic acid esters elicited remarkable inhibitory effects on erythrocyte membrane lipid peroxidation, cellular DNA strand breakage, and protein fragmentation. The results suggest that CAPE is a potent exogenous cytoprotective and antigenotoxic agent against cell oxidative damage that could be used as a template for designing novel drugs to combat diseases induced by oxidative stress components, such as various types of cancer.


2015 ◽  
Vol 74 (OCE3) ◽  
Author(s):  
G. Kapravelou ◽  
K. Brahim ◽  
M Goua ◽  
R. Martínez ◽  
M. Lopez-Jurado ◽  
...  

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