Colistin resistance in Gram-negative ocular infections: prevalence, clinical outcome and antibiotic susceptibility patterns

2020 ◽  
Vol 40 (5) ◽  
pp. 1307-1317
Author(s):  
Sanchita Mitra ◽  
Soumyava Basu ◽  
Suryasnata Rath ◽  
Srikant Kumar Sahu
Keyword(s):  
Clinical Outcome ◽  
Antibiotic Susceptibility ◽  
Colistin Resistance ◽  
Gram Negative ◽  
Ocular Infections ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

scholarly journals Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina

2014 ◽  
Vol 8 (06) ◽  
pp. 699-704 ◽  
Author(s):  
Hugo E Villar ◽  
Mónica B Jugo ◽  
Alejandro Macan ◽  
Matias Visser ◽  
Mariana Hidalgo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adult Male ◽  
Antimicrobial Susceptibility ◽  
Antibiotic Susceptibility ◽  
Urine Samples ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Gram Negative ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

Introduction: Knowledge of the etiology and antimicrobial susceptibility patterns of uropathogens is important for determining the best treatment option. This study aimed to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from adult male outpatients. Methodology: Between November 2012 and April 2013, 3,105 community urine samples were analyzed from adult male patients who attended the Laboratorio Hidalgo, Buenos Aires, Argentina. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disc diffusion method. Isolates resistant to third generation cephalosporin were tested for extended-spectrum beta-lactamase (ESBL) production using the double-disk synergy test. Results: Of the 3,105 urine samples analyzed, 791 (25.5%) had significant bacteriuria. The frequency of positive urine cultures increased significantly with patient age. Escherichia coli was isolated most frequently (47.3%), followed by Enterococcus faecalis (13.6%), and Klebsiella pneumoniae (11.9%). Gram-negative organisms represented 78.8% of urinary pathogens. The highest activities against Gram-negative bacteria were found with imipenem (99.0%), amikacin (98.1%), ertapenem (94.2%), fosfomycin (90.7%), and piperacillin-tazobactam (90.1%). The frequencies of ESBLs among E. coli, K. pneumoniae, and P. mirabilis were 15.2 %, 22.3%, and 8%, respectively. Fosfomycin, piperacillin-tazobactam, and nitrofurantoin were most effective against Gram-positive organisms. Conclusions: Fosfomycin may be an excellent option for cystitis treatment in patients without risk factors, whereas piperacillin-tazobactam is preferred for the treatment of parenchymatous UTIs, complicated UTIs, and UTIs associated with risk factors. To ensure the optimal selection of antibiotics, physicians should have access to up-to-date information about the local prevalence of antimicrobial resistance.

scholarly journals Antibiotic susceptibility patterns of biofilm producing gram negative bacilli isolated from Kilis local cheese

2020 ◽  
Vol XI (21) ◽  
pp. 58-63
Author(s):  
Hatice Aysun MERCIMEK TAKCI ◽  
Pemra BAKIRHAN ◽  
Eda OZDEMIR ◽  
Aysenur YALCIN
Keyword(s):  
Antibiotic Susceptibility ◽  
Gram Negative ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

scholarly journals Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon

10.3823/823 ◽  
2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Monzer Hamze
Keyword(s):  
Antibiotic Susceptibility ◽  
Susceptibility Testing ◽  
Tertiary Care ◽  
Resistant Bacteria ◽  
Major Public Health Problem ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Carbapenem Resistant ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

Background. Antimicrobial resistance is a major public health problem worldwide. Numerous epidemiological studies reported that Lebanon is affected with high levels of antibiotic resistance. The aim of this study is to determine the prevalence and antibiotic susceptibility patterns of carbapenem resistant Gram negative bacteria in North Lebanon during the period 2015-2017. Methods. Carbapenem resistant Gram negative bacteria were isolated from patients referring to Nini hospital and Youssef hospital center. Identification and antibiotic susceptibility testing were performed through conventional tools according to the manufacturer’s recommended procedures and the recommendations of the European Committee on Antimicrobial Susceptibility Testing, respectively. Results. Overall, a total of 290 carbapenem resistant Gram negative bacteria were isolated. Escherichia coli was predominant and represented 39.3% of all isolates, followed by Pseudomonas aeruginosa (24.8%), Acinetobacter baumannii (22.8%), Klebsiella spp. (8.6%), Enterobacter spp. (6.6%), Pantoea spp. (1%), and Proteus vulgaris (0.3%). Our findings showed an alarming increase in the prevalence of carbapenem resistant bacteria every year. On the other hand, colistin, tigecycline, amikacin and fosfomycin remain the most effective agents against carbapenem resistant Gram negative bacteria. Conclusion. This study provided important new laboratory data that could support specialists in infectious diseases in North Lebanon to take the appropriate decision in the treatment of patients at risk for infections with carbapenem resistant Gram negative germs.

scholarly journals THU0426 CLINICAL CHARACTERISTIC OF INFECTIOUS ULCERATION OVER TOPHI

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 451.2-452
Author(s):  
Z. Huang ◽  
T. LI ◽  
X. Liu
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Antibiotic Susceptibility ◽  
Clinical Characteristics ◽  
Albumin Level ◽  
Gram Positive ◽  
Gram Negative ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

Background:Infection in ulceration over tophi is the leading cause of sepsis in patients with gout, which is the main indication for surgery. Additionally, patients with infection will significantly prolonged wound closure time compared with those without infection. Investigation of infection in ulceration over tophi will improve our understanding of this critical issue.Objectives:To describe the microbiological profile in ulceration over tophi, antibiotic susceptibility patterns of causative agents, and to study the prediction of infection in ulceration over tophi among patients with gout.Methods:Patients with ulceration over tophi were prospectively enrolled. The clinical characteristics were recorded and microbiological specimens were taken on admission. Specimens were cultured for aerobic and anaerobic bacteria, and antibiotic susceptibility testing was performed for the culture isolates. Patients were divided into 2 groups according to having infectious ulceration or not and the potential risk factors for infectious ulceration over tophi were examined using univariate and multivariate logistic regression analyses.Results:A total of 82 patients were included for analysis. 46 pathogens were isolated from 39 (47.6%) patients, among which the top 3 wereStaphylococcus aureus(43.5%),Pseudomonas aeruginosa(17.4%) andEnterococcus faecalis(13.0%). Overall, the Gram-positive bacilli were more sensitive to gentamicin (81.5%), amikacin (88.9%), trimethoprim/sulfamethoxazole (92.6%), nitrofurantoin (96.3%), linezolid (100.0%), teicoplanin (100.0%) and vancomycin (100.0%) whereas penicillin, oxacillin and ampicillin were 66.7% to 77.8% resistant. The Gram-negative bacilli were more sensitive to amikacin (84.2%), cefoperazone/sulbactam (84.2%) and meropenem (89.5%) whereas ampicillin, amoxicillin/clavulanate, cefotaxime, cefazolin, piperacillin, trimethoprim/sulfamethoxazole and tetracycline were 68.4% to 100% resistant. Patients with infection had a higher rate of smoking history and type 2 diabetes, with higher levels of erythrocyte sedimentation rate, C-reactive protein and leucocyte, and lower level of albumin. In stepwise logistic regression analysis, type 2 diabetes (adjusted OR 5.064; 95% CI = 1.430 to 17.928) and albumin level (adjusted OR 0.855; 95% CI = 0.782 to 0.935) were independent predictors of infection in ulceration over tophi.Conclusion:Infection is common in ulceration over tophi. Different antibiotic susceptibility patterns were observed in Gram-positive bacilli and Gram-negative bacilli. Type 2 diabetes and low albumin level were associated with an increased risk of infection in ulceration over tophi. The data in this study will be beneficial for tailoring infection control measures in a way that improves outcomes of ulceration over tophi.References:[1]Huang Z, Liu X, Liu Y, et al. Clinical characteristics and risk factors of ulceration over tophi in patients with gout.International journal of rheumatic diseases2019;22:1052-7.[2]Xu J, Zhu Z, Zhang W. Clinical characteristics of infectious ulceration over tophi in patients with gout.The Journal of international medical research2018;46:2258-64.Table 1.Bacteria isolated from initial ulceration specimens taken on the first admission.BacteriaNumber* (n = 46)Proportion (%)Gram-positive bacilli2758.7 Staphylococcus aureus2043.5 Enterococcus faecalis613.0 Streptococcus mutans12.2Gram-negative bacilli1941.3 Pseudomonas aeruginosa817.4 Klebsiella pneumonia48.7 Enterobacter cloacae36.5 Escherichia coli24.3 Acinetobacter baumannii24.3* Number of ulcerationDisclosure of Interests: :None declared

scholarly journals Antibiotic susceptibility patterns of bacteria isolates in post-operative wound infections among patients attending Mama Lucy Kibaki Hospital, Kenya

2019 ◽  
Author(s):  
Johnstone Amulioto ◽  
Margaret W. Muturi ◽  
Scholastica Mathenge ◽  
Gideon M. Mutua
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
Surgical Site Infections ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Wound Infections ◽  
Gram Negative ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns ◽  
Operative Wound

Abstract Background Surgical site infections accounts for high mortality rates, morbidity and elevated costs of treatment for surgical patients. In recent years, surgical site infections attributed to antibiotic resistant bacteria has been on the rise globally. To effectively formulate a comprehensive treatment protocol for surgical site infection, there is need for knowing the likely causative agents and their antibiograms. In this regard, this study sought to determine the prevalence and antibiotic susceptibility patterns of bacteria isolates from post-operative wound infections among patients attending Mama Lucy Kibaki Hospital.Methods A cross-sectional descriptive study was carried out between October 2018 and March 2019. The study included patients of all age group with surgical site infections following general, obstetrics and gynecological surgeries. Pus swabs were aseptically obtained from 58 consented patients with clinical evidence of surgical site infections. Gram stain, culture, biochemical tests and antibiotic susceptibility tests were done for each pus swab. Antibiotic susceptibility testing was done using Kirby bauer disc diffusion method. Data was analysed using a statistical package for the social sciences (SPSS) version 20.Results An isolation rate of 94.8% was observed. Staphylococcus aureus 28.2% was the preponderant isolate followed by Escherichia coli 15.4% with Methicillin resistant Staphylococcus aureus accounting for 65.4% (n=17) of the total Staphylococcus species . Chloramphenicol was the most sensitive drug to all the bacteria isolates. Ampicillin and Amoxycillin recorded resistance rates >90% against positive and gram negative bacteria respectively. Klebsiella pneumoniae 81.3% and E.coli 74% were the most resistant bacteria.Conclusion Majority of the drugs were resistant to gram negative rods, therefore there is need for continuous monitoring to determine the susceptibility patterns of the most common surgical site infections bacteria isolates which are found in the hospitals.

Sign in / Sign up

Export Citation Format

Share Document