Method for Separation of Blood Vessels on the Three-Color Images of Biological Tissues

2017 ◽  
Vol 84 (3) ◽  
pp. 439-447 ◽  
Author(s):  
S. A. Lisenko
Keyword(s):  
Blood Vessels ◽  
Biological Tissues ◽  
Color Images

Enhancement of OCT imaging by blood optical clearing in vessels – A feasibility study

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Olga Zhernovaya ◽  
Valery V. Tuchin ◽  
Martin J. Leahy
Keyword(s):  
Light Scattering ◽  
Blood Vessels ◽  
Feasibility Study ◽  
Biological Tissues ◽  
Intradermal Injection ◽  
Light Transport ◽  
Optical Clearing ◽  
Intravenous Injections ◽  
Oct Imaging ◽  
System Operating

AbstractThe results of a feasibility study of the application of PEG-300 and fructose as two independent optical clearing agents for the reduction of light scattering in biological tissues are presented.An OCT system operating at 1300 nm was used to study optical clearing effects. InThe intradermal injection of fructose in combination with the intravenous injection of PEG-300 led to a rapid optical clearing effect. In the experiments on miceThe experiments on mice have clearly demonstrated that intradermal and intravenous injections of optical clearing agents enhanced light transport through the skin and blood vessels.

Monte Carlo Simulation of Photon Transport for Computing Fluence Rate in Biological Tissue

2018 ◽  
Vol 13 (10) ◽  
pp. 1505-1513
Author(s):  
S. O. Bazara ◽  
R. S. Alanazi ◽  
A. Laref
Keyword(s):  
Monte Carlo ◽  
Absorption Coefficient ◽  
Blood Vessels ◽  
Biological Tissue ◽  
Theoretical Perspective ◽  
Biological Tissues ◽  
Point Sources ◽  
Fluence Rate ◽  
Photon Transport ◽  
Collimated Beam

In this research, we applied the Monte Carlo method to simulate photon transport in a biological tissue, consisting of epidermal, dermis, and blood vessels. Particularly, we computed the fluence rate of the system at a wavelength of 400 nm using different beam sources, such as collimated beam, Gaussian beam, and isotropic point sources. In addition, the fluence rate is calculated within the collimated beam at different wavelengths between 300–1000 nm by considering the absorption coefficient (μa) for blood, dermis, and epidermis. For the collimated beam, the resulting fluence rate was found almost similar in the case of the epidermis and dermis at wavelengths between 600–1000 nm, whereas the blood vessels occur at a wavelength of 400 nm with a maximum absorption coefficient of blood (μa) of 3586 cm–1. The present study illustrated the ability of the penetration of light in biological tissues and the escaped light could provide the information about the components of the biological tissue. From the theoretical perspective, the comprehension of light-tissue interactions can support the field of biomedical optics.

Analysis of Ultrafast Laser Propagation in Biological Tissues With Embedded Tumors and Large Blood Vessels

2006 ◽  
Author(s):  
Jianhua Zhou ◽  
Yuwen Zhang ◽  
J. K. Chen
Keyword(s):  
Refractive Index ◽  
Blood Vessels ◽  
Light Propagation ◽  
Monte Carlo Model ◽  
Biological Tissues ◽  
Propagation Path ◽  
Direct Result ◽  
Time Resolved ◽  
Laser Propagation ◽  
Foreign Objects

Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the "second peak" be an indication for the location and size of tumors inside the tissue.

scholarly journals Transport phenomena in complex systems (part 1)

2021 ◽  
Vol 379 (2205) ◽  
pp. 20200301
Author(s):  
Dmitri V. Alexandrov ◽  
Andrey Yu Zubarev
Keyword(s):  
Complex Systems ◽  
Blood Vessels ◽  
Transport Phenomena ◽  
Experimental Studies ◽  
Computational Modelling ◽  
Biological Tissues ◽  
Transport Processes ◽  
Nonlinear Transport ◽  
The Impact

The issue, in two parts, is devoted to theoretical, computational and experimental studies of transport phenomena in various complex systems (in porous and composite media; systems with physical and chemical reactions and phase and structural transformations; in biological tissues and materials). Various types of these phenomena (heat and mass transfer; hydrodynamic and rheological effects; electromagnetic field propagation) are considered. Anomalous, relaxation and nonlinear transport, as well as transport induced by the impact of external fields and noise, is the focus of this issue. Modern methods of computational modelling, statistical physics and hydrodynamics, nonlinear dynamics and experimental methods are presented and discussed. Special attention is paid to transport phenomena in biological systems (such as haemodynamics in stenosed and thrombosed blood vessels magneto-induced heat generation and propagation in biological tissues, and anomalous transport in living cells) and to the development of a scientific background for progressive methods in cancer, heart attack and insult therapy (magnetic hyperthermia for cancer therapy, magnetically induced circulation flow in thrombosed blood vessels and non-contact determination of the local rate of blood flow in coronary arteries). The present issue includes works on the phenomenological study of transport processes, the derivation of a macroscopic governing equation on the basis of the analysis of a complicated internal reaction and the microscopic determination of macroscopic characteristics of the studied systems. This article is part of the theme issue ‘Transport phenomena in complex systems (part 1)’.

scholarly journals Label-Free Imaging of Blood Vessels in Human Normal Breast and Breast Tumor Tissue Using Multiphoton Microscopy

Scanning ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Gangqin Xi ◽  
Ning Cao ◽  
Wenhui Guo ◽  
Deyong Kang ◽  
Zhong Chen ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Blood Vessels ◽  
Breast Tumor ◽  
Tumor Tissue ◽  
Second Harmonic ◽  
Multiphoton Microscopy ◽  
Biological Tissues ◽  
Normal Breast ◽  
Label Free ◽  
Breast Tumor Tissue

Blood vessels are the important components of the circulatory systems that transport blood throughout the human body and maintain the homeostasis of physiological tissues. Pathologically, blood vessels are often affected by diseases, leading to the formation of unstable, irregular, and hyperpermeable blood vessels. In the tumor microenvironment, abnormal leakage of tumor blood vessels is related to the histological grade and malignant potential of tumors and may also facilitate metastasis of cancer. Visual diagnosis of blood vessels is very important for us to understand the occurrence and development of diseases. Multiphoton microscopy (MPM) is a potential label-free diagnostic tool based on second harmonic generation (SHG) and two-photon excited fluorescence (TPEF). MPM can effectively observe the morphological changes of biological tissues at the molecular and cellular levels. In this work, we demonstrate that label-free MPM can be used to visualize the microstructure of blood vessels in human normal breast and breast tumor tissue. Moreover, MPM can monitor the changes of blood vessels in tumor microenvironment. These results show that the MPM will become a promising technique for clinicians to study the properties of the microstructure of the blood vessels.

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