Association of 3-O-methylquercetin with β-cyclodextrin: complex preparation, characterization and ex vivo skin permeation studies

2008 ◽  
Vol 62 (1-2) ◽  
pp. 149-159 ◽  
Author(s):  
Liege Schwingel ◽  
Daniel Fasolo ◽  
Maribete Holzschuh ◽  
Ivana Lula ◽  
Rubén Sinisterra ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Skin Permeation ◽  
Cyclodextrin Complex ◽  
Complex Preparation ◽  
Permeation Studies

Emulgels Containing Carbopol 934P and Different Vegetable Oils for Topical Propolis Delivery: Bioadhesion, Drug Release Profile, and Ex Vivo Skin Permeation Studies

2020 ◽  
Vol 21 (6) ◽  
Author(s):  
Rafaela Said dos Santos ◽  
Camila Félix Vecchi ◽  
Hélen Cássia Rosseto ◽  
Jéssica Bassi da Silva ◽  
Maria Eduarda Lima Dano ◽  
...  
Keyword(s):  
Drug Release ◽  
Vegetable Oils ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Release Profile ◽  
Drug Release Profile ◽  
Permeation Studies ◽  
Carbopol 934P

scholarly journals Microemulsion System for Topical Delivery of Thai Mango Seed Kernel Extract: Development, Physicochemical Characterisation and Ex Vivo Skin Permeation Studies

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 17107-17129 ◽  
Author(s):  
Jiraporn Leanpolchareanchai ◽  
Karine Padois ◽  
Françoise Falson ◽  
Rapepol Bavovada ◽  
Pimolpan Pithayanukul
Keyword(s):  
Ex Vivo ◽  
Skin Permeation ◽  
Topical Delivery ◽  
Microemulsion System ◽  
Seed Kernel ◽  
Mango Seed Kernel ◽  
Permeation Studies ◽  
Physicochemical Characterisation ◽  
Mango Seed

scholarly journals Enhancement of Curcumin Anti-Inflammatory Effect via Formulation into Myrrh Oil-Based Nanoemulgel

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 577 ◽  
Author(s):  
Wafaa E. Soliman ◽  
Tamer M. Shehata ◽  
Maged E. Mohamed ◽  
Nancy S. Younis ◽  
Heba S. Elsewedy
Keyword(s):  
Ex Vivo ◽  
Skin Permeation ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Delivery Methods ◽  
Anti Cancer ◽  
Permeation Studies ◽  
Anti Inflammatory

Background: Curcumin (Cur) possesses a variety of beneficial pharmacological properties including antioxidant, antimicrobial, anti-cancer and anti-inflammatory activities. Nevertheless, the low aqueous solubility and subsequent poor bioavailability greatly limits its effectiveness. Besides, the role of myrrh oil as an essential oil in treating inflammatory disorders has been recently demonstrated. The objective of the current investigation is to enhance Cur efficacy via developing Cur nanoemulgel, which helps to improve its solubility and permeability, for transdermal delivery. Methods: The formulated preparations (Cur gel, emulgel and nanoemulgel) were evaluated for their physical appearance, spreadability, viscosity, particle size, in vitro release and ex vivo drug permeation studies. The in vivo anti-inflammatory activity was estimated using the carrageenan-induced rat hind paw edema method. Results: The formulated Cur-loaded preparations exhibited good physical characteristics that were in the acceptable range of transdermal preparations. The release of Cur from gel, emulgel and nanoemulgel after 12 h was 72.17 ± 3.76, 51.93 ± 3.81 and 62.0 ± 3.9%, respectively. Skin permeation of Cur was significantly (p < 0.05) improved when formulated into nanoemulgel since it showed the best steady state transdermal flux (SSTF) value (108.6 ± 3.8 µg/cm2·h) with the highest enhancement ratio (ER) (7.1 ± 0.2). In vivo anti-inflammatory studies proved that Cur-loaded nanoemulgel displayed the lowest percent of swelling (26.6% after 12 h). Conclusions: The obtained data confirmed the potential of the nanoemulgel dosage form and established the synergism of myrrh oil and Cur as an advanced anti-inflammatory drug.

Development and Characterization of Apremilast Transethosomal Gel for Transdermal Delivery

2021 ◽  
Vol 14 (3) ◽  
pp. 5508-5518
Author(s):  
Mrunal Rahangdale ◽  
Prachi Pandey
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Oral Route ◽  
Tem Analysis ◽  
Vesicle Size ◽  
Ex Vivo Permeation ◽  
Permeation Studies

The apremilast is anti-inflammatory drug and PDE-4 inhibitor, used in treatment of psoriasis. The oral route of apremilast has limitation of GI irritation and frequent dosage regimen.The objective of the present work was aimed to prepare transethosomal gel of apremilast to achieve more skin permeation, more drug entrapment efficiency and sustained release. The transethosome vesicle containing apremilast was prepared by using Rotary vacuum evaporator, followed by probe sonication. The Box-Behnken design was used to optimize the formulation by taking quantity of lipoid        S 100, sodium cholate and ethanol as independent variable and vesicle size, entrapment efficiency and cumulative drug release as dependent variable. The optimized batch of transethosome vesicle was incorporated in 1 % of Carbopol gel base. The prepared optimized batch was evaluated for size, zeta potential, surface morphology, pH, viscosity, spreadability, extrudability, drug content and ex-vivo permeation studies. The result showed that optimized batch of transethosome was found to have vesicle size of 130.8 nm, entrapment efficiency of 62.83 % and cumulative drug release of gel 73.13 %. The transethosome vesicles were found to be spherical and uniform in size based on TEM analysis. The ex-vivo permeation studies were performed for 24 hrs through the rat skin. The formulation was found to show better skin permeation and sustained release. The formulation showed satisfactory result with respect to pH, gel characteristics and stability. Thus, can concluded that transethosomal gel containing apremilast could be an effective option for treatment of psoriasis.

scholarly journals Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies

2019 ◽  
Vol 127 ◽  
pp. 228-236 ◽  
Author(s):  
Oludemi Taofiq ◽  
Francisca Rodrigues ◽  
Lillian Barros ◽  
Maria F. Barreiro ◽  
Isabel C.F.R. Ferreira ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Skin Permeation ◽  
Ethanolic Extracts ◽  
Permeation Studies

scholarly journals Nanoemulsification Improves the Pharmaceutical Properties and Bioactivities of Niaouli Essential Oil (Melaleuca quinquenervia L.)

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4750
Author(s):  
Faiyaz Shakeel ◽  
Mounir M. Salem-Bekhit ◽  
Nazrul Haq ◽  
Sultan Alshehri
Keyword(s):  
Essential Oil ◽  
Staphylococcus Epidermidis ◽  
Ex Vivo ◽  
Acne Vulgaris ◽  
Skin Permeation ◽  
Melaleuca Quinquenervia ◽  
Ex Vivo Permeation ◽  
Permeation Studies ◽  
Pharmaceutical Properties

We develop a suitable delivery system for niaouli essential oil (NEO) using a nanoemulsification method for acne vulgaris. Prepared nanoemulsions (NEs) were characterized for droplet dimension, rheology, surface charge, and stability. The ability of NEO formulations against Propionibacterium acnes and Staphylococcus epidermidis was investigated and all formulations showed antiacne potential in vitro. Ex vivo permeation studies indicated significant improvement in drug permeations and steady state flux of all NEO-NEs compared to the neat NEO (p < 0.05). On the basis of the studied pharmaceutical parameters, enhanced ex vivo skin permeation, and marked effect on acne pathogens, formulation NEO-NE4 was found to be the best (oil (NEO; 10% v/v); Kolliphor EL (9.25% v/v), Carbitol (27.75% v/v), and water (53% v/v)). Concisely, the in vitro and ex vivo results revealed that nanoemulsification improved the delivery as well as bioactivities of NEO significantly.

scholarly journals Topical Amphotericin B Semisolid Dosage Form for Cutaneous Leishmaniasis: Physicochemical Characterization, Ex Vivo Skin Permeation and Biological Activity

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 149 ◽  
Author(s):  
Diana Berenguer ◽  
Maria Magdalena Alcover ◽  
Marcella Sessa ◽  
Lyda Halbaut ◽  
Carme Guillén ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Amphotericin B ◽  
Cell Lines ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Physicochemical Characterization ◽  
Keratinocyte Cell ◽  
Permeation Studies

Amphotericin B (AmB) is a potent antifungal successfully used intravenously to treat visceral leishmaniasis but depending on the Leishmania infecting species, it is not always recommended against cutaneous leishmaniasis (CL). To address the need for alternative topical treatments of CL, the aim of this study was to elaborate and characterize an AmB gel. The physicochemical properties, stability, rheology and in vivo tolerance were assayed. Release and permeation studies were performed on nylon membranes and human skin, respectively. Toxicity was evaluated in macrophage and keratinocyte cell lines, and the activity against promastigotes and intracellular amastigotes of Leishmania infantum was studied. The AmB gel remained stable for a period of two months, with optimal properties for topical use and no apparent toxic effect on the cell lines. High amounts of AmB were found in damaged and non-damaged skin (1230.10 ± 331.52 and 2484.57 ± 439.12 µg/g/cm2, respectively) and they were above the IC50 of AmB for amastigotes. Although there were no differences in the in vitro anti-leishmanial activity between the AmB solution and gel, the formulation resulted in a higher amount of AmB being retained in the skin, and is therefore a candidate for further studies of in vivo efficacy.

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